The Relative Frequency of Iron Deficiency Anemia and its Correlation with Pulmonary Function in Children with Cystic Fibrosis
Student Research in Translational Medicine,
Vol. 2 No. 1 (2020),
1 Esfand 2020
,
Page 15-19
https://doi.org/10.22037/smsj.v2i1.29392
Abstract
Background and Aims: The prevalence of iron deficiency is increasing in the population of cystic fibrosis patient (CF). The aim of this study was to determine the prevalence of iron deficiency anemia and its correlation with pulmonary function in cystic fibrosis patients.
Materials and Methods: This descriptive-analytic study was done on the patients with cystic fibrosis who were referred to the Mofid Children Hospital, Tehran, Iran during 2015-2016. Complete blood counting and iron indices were evaluated; furthermore, Pulmonary function test was performed in ≥5 years old patients to determine the forced expiratory volume in first second (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow (FEF25-75). The data were analyzed by SPSS software. Pearson correlation coefficient, t-test, Fisher's exact test and χ2 were used for analyzing data.
Results: Among 30 patients who were able to perform spirometry, Spirometric findings were normal in 12 patients (40%) which 72% of them were female. There was a statistically significant correlation between the spirometric findings and the gender of the patients (P<0.05), but the correlation between the gender and iron indices was not significant (P>0.05). Moreover, there was no statistically significant correlation between spirometric findings and iron indices (P> 0.05).
Conclusion: There was no significant correlation between iron deficiency and pulmonary function in cystic fibrosis patients.
- Cystic fibrosis
- Iron deficiency
- Pulmonary function
How to Cite
References
Cutting GR. Cystic fibrosis genetics: from molecular understanding to clinical application. Nat Rev Genet. 2015;16(1):45.
Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest. 2002;109(5):571-7.
Flume PA, O'sullivan BP, Robinson KA, Goss CH, Mogayzel Jr PJ, Willey-Courand DB, et al. Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health. Am J Respir Crit Care Med. 2007;176(10):957-69.
Christoforou E, Papassotiriou I, Skarmoutsou C, Doudounakis S, Stamoulakatou A, Kanavakis E. Soluble transferrin receptors and tissue oxygenation in non anaemic cystic fibrosis patients. J Cyst Fibros. 2005;4(3):151-6.
Reid DW, Withers NJ, Francis L, Wilson JW, Kotsimbos TC. Iron deficiency in cystic fibrosis: relationship to lung disease severity and chronic Pseudomonas aeruginosa infection. Chest. 2002;121(1):48-54.
Gifford AH, Alexandru DM, Li Z, Dorman DB, Moulton LA, Price KE, et al. Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis. J Cyst Fibros. 2014;13(3):311-8.
Fischer R, Simmerlein R, Huber R, Schiffl H, Lang S. Lung disease severity, chronic inflammation, iron deficiency, and erythropoietin response in adults with cystic fibrosis. Pediatr Pulmonol. 2007;42(12):1193-7.
von Drygalski A, Biller J. Anemia in Cystic Fibrosis (CF): Prevalence, Mechanisms and Correlation with Pulmonary Function. Blood. 2006; 108: 1286.
von Drygalski A, Biller J. anemia Is A Serious Comorbid Condition In Cystic Fibrosis (cf) And Is Associated With Poor Lung Function: 491⋆. Pediatr Pulmonol. 2007;42:378.
von Drygalski A, Biller J. Anemia in cystic fibrosis: incidence, mechanisms, and association with pulmonary function and vitamin deficiency. Nutr Clin Pract. 2008;23(5):557-63.
Zempsky WT, Rosenstein BJ, Carroll JA, Oski FA. Effect of pancreatic enzyme supplements on iron absorption. Am J Dis Child. 1989;143(8):969-72.
Cucchiara S, Santamaria F, Andreotti M, Minella R, Ercolini P, Oggero V, et al. Mechanisms of gastro-oesophageal reflux in cystic fibrosis. Arch Dis Child. 1991;66(5):617-22.
Elin RJ, Wolff SM, Finch CA. Effect of induced fever on serum iron and ferritin concentrations in man. Blood. 1977;49(1):147-53.
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110(7):1037-44.
Vichinsky EP, Pennathur-Das R, Nickerson B, Minor M, Kleman K, Higashino S, et al. Inadequate erythroid response to hypoxia in cystic fibrosis. J Pediatr. 1984;105(1):15-21.
O'connor T, McGrath D, Short C, O'donnell M, Sheehy M, Bredin C. Subclinical anaemia of chronic disease in adult patients with cystic fibrosis. J Cyst Fibros. 2002;1(1):31-4.
Fustik S, Jakovska T, Spirevska L. Hypoproteinemia and anemia in infants with cystic fibrosis. J Cyst Fibros. 2008;7:S97.
Kessel A, Halloun H, Bamberger E, Kugelman A, Toubi E. Abnormal spirometry in children with persistent allergic rhinitis due to mite sensitization: the benefit of nasal corticosteroids. Pediatr Allergy Immunol. 2008;19(1):61-6.
Lerner NB SR. Iron-Deficiency Anemia. In: Kliegman R NW, editor. Nelson textbook of pediatrics. Philadelphia: Elsevier Health Sciences; 2015. p. 5929.
P L. Manual of Pediatric Hematology and Oncology Fifth Edition ed. San Diego: Academic Press; 2011.
Hansen S, Houghton L, Freitag A, Labiris R. 317 Anemia in adult patients with cystic fibrosis (CF). J Cyst Fibros. 2006;5:S74.
Uijterschout L, Nuijsink M, Hendriks D, Vos R, Brus F. Iron deficiency occurs frequently in children with cystic fibrosis. Pediatr Pulmonol. 2014;49(5):458-62.
Pond M, Morton A, Conway S. Functional iron deficiency in adults with cystic fibrosis. Respir Med. 1996;90(7):409-13.
- Abstract Viewed: 242 times
- PDF Downloaded: 121 times
