Design Hybrid Nanogel of Prednisolone for Topical Application, Preparation, Characterization, In-vitro and Ex-vivo Evaluation Hybrid Nanogel of Prednisolone
Iranian Journal of Pharmaceutical Sciences,
Vol. 19 No. 3 (2023),
1 July 2023
,
Page 194- 207
https://doi.org/10.22037/ijps.v19i3.42239
Abstract
The prednisolone was very slightly soluble in water. It was a curative agent against oral recurrent aphthous stomatitis. The main objective of this study is to design, prepare, and evaluate a hybrid nanogel of prednisolone as a topical dosage form to increase prednisolone solubility, stability, and therapeutic activity. The microwave-based method prepared nine prednisolone lipid polymer hybrid nanocarriers LPHNs formulations (H1-H9). The conventional prednisolone gel (G) was prepared by solvent diffusion. The H1-H9 was evaluated thermodynamically and entered into characterization processes. The hybrid nanogels HN1-HN9 formulations were tested for various evaluations. All the H1-H9 formulations showed high thermodynamic stability and nanosized globules, low polydispersity index, acceptable surface charge, entrapment efficiency, and drug loading. The evaluation processes indicate stable organoleptic properties, high homogeneity, fair pH and spreadability coefficient values with plastic viscosity and no erythemic reaction. The profile of prednisolone release and permeability coefficient (cm/min) was significantly higher (p-value <0.05) for HN3 and significantly lower (p-value < 0.05) for conventional prednisolone gel (G). The optimized HN1-HN9 formulations were promised drug delivery systems for treating recurrent aphthous stomatitis and a wide variety of oral lesions in addition to local and transdermal delivery of various therapeutic agents and cosmetics.
- Recurrent aphthous stomatitis
- Microwave-based method
- Prednisolone
- Chitosan
- Cardamom oil
- Topical pharmaceutical dosage form
How to Cite
References
2. Belenguer GI, Yolanda JS, Ariadna CL.Treatment of recurrent aphthous stomatitis. A literature review. Journal of Clinical and Experimental Dentistry (2014) 6: 168 - 174.
3. Sharma D, Rajeev G. A comprehensive review on aphthous stomatitis, its types, management and treatment available. Journal of Developing Drugs (2018) 7.
4. Mehdipour M, Ali TZ. Role of corticosteroids in oral lesions(2012).
5. Gibson N, Ferguson JW. Steroid cover for dental patients on long-term steroid medication: proposed clinical guidelines based upon a critical review of the literature. British Dental Journal (2004) 197 (11): 681–685
6. Zakeri P, Somayeh HN, Mohammad BJ, Leila M, Ali N, Hadi V. Studies on dissolution enhancement of prednisolone, a poorly water-soluble drug by solid dispersion technique. Advanced pharmaceutical bulletin (2011) 11: 48-53.
7. Spireas S, Srinivas S. Enhancement of prednisolone dissolution properties using liquisolid compacts. International Journal of Pharmaceutics (1998) 166:177-188.
8. Jiang Y, Chen J, Deng C, Suuronen EJ, Zhong Z, Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering. Biomaterials (2014) 35: 4969–4985.
9. Soni KS. Desale SS. Bronich TK. Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation. J. Control Release (2016) 240: 109–126.
10. Li Y, Maciel D, Rodrigues J, Shi X. Tomás H. Biodegradable polymer nanogels for drug/nucleic acid delivery. Chem. Rev (2015) 115:8564–8608.
11. Siddartha VT, Gowthamarajan K, Veera VS, Reddy K, Shashank T, Subba VM. Lipid-based nanocarriers for breast cancer treatment – a comprehensive review. Drug Delivery (2016) 23(4):1291-1305.
12. Talluri SV, Kuppusamy G, Karri VV Tummala S, Madhunapantula, SV. Lipid-based nanocarriers for breast cancer treatment - a comprehensive review. Drug Delivery (2016) 23(4):1291–1305.
13. Drais HK, Hussein AA. Design and preparation lipid-polymer hybrid nanocarrier as pulmonary dispersion system using a novel microwave method. Research Journal of Pharmacy and Technology (2021) 14:1233-7.
14. Hadinoto K, Sundaresan A. Cheow WS. Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur J Pharm Biopharm (2013) 85: 427–43.
15. Drais HK, Hussein AA. Lipid-polymer hybrid nanocarriers for oral delivery of felodipine: formulation, characterization and ex-vivo Evaluation. Advanced Pharmaceutical Bulletin (2022) 12(4), 791-800.
16. Drais HK, Hussein AA. Formulation and evaluation lipid-polymer hybrid nanocarriers using a new innovative microwaves-based method. International Journal of Pharmaceutical Research (2020)12 (4):1264-9.
17. Bhattacharya S, Bhupendra GP. Formulation and optimization of celecoxib nanoemulgel. Asian Journal of Pharmaceutical and Clinical Research (2017) 10(8): 353-365.
18. Muniraj SN, Yogananda R, Nagaraja TS, Bharathi DR. Preparation and characterization of nanogel drug delivery system containing clotrimazole an anti-fungal drug. Indo American Journal of Pharmaceutical Research (2020) 10 (07): 1013-1022
19. Kurakula M, Srinivas C, Nagasree K, Prakash VD. Formulation and evaluation of prednisolone proliposomal gel for effective topical pharmacotherapy. International Journal of Pharmaceutical Sciences and Drug Research (2012): 35-43.
20. Rahmawati D, Iwan S. Formulation and physical stability test of gel fruit strawberry extract (Fragaria x ananassa Duch.). Journal of Nutraceuticals and Herbal Medicine (2019) 2(1): 38-46.
21. Pathan IB, Rashmi D, Wahid A. Formulation and evaluation of ketoprofen loaded chitosan nanogel for pain management: Ex-vivo and In-vivo study. Ars Pharm (2019) 60(2): 101-108
22. Naga S, Kumar V, Prashant M, Navya M, Sharath R, Hosakote GS, Gowda DV. Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharmaceutical Journal (2014) 22: 591-599.
23. Mao Y, Xiaolan C, Bohui X, Yan S, Zixuan Y, Birendra C, Li L, Yi L, Xiaoling X. Daquan C. Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation. Drug Delivery (2019) 26: 1104 - 1114.
- Abstract Viewed: 238 times
- IJPS_Volume19_Issue3_Pages 194-207 Downloaded: 132 times