Synthesis and Characterization of Hydroxyapatite Nanocrystalsvia Chemical Precipitation Technique Synthesis and characterization of hydroxyapatite
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 2 (2008),
1 Farvardin 2008
,
Page 127-134
https://doi.org/10.22037/ijps.v4.41097
Abstract
In this study, hydroxyapatite (HA) nanocrystals have been synthesized via chemical precipitation technique. Diammonium hydrogen phosphate and calcium nitrate 4-hydrate were used as starting materials and sodium hydroxide solution was used as the agent for pH adjustment. The powder sample was evaluated by techniques such as scanning electron microscope, transmission electron microscope, Fourier transform infra-red spectroscopy, differential thermal analysis, thermal gravimetric analysis, X-ray diffraction, atomic absorption spectroscopy and EDTA titrationan alyses. According to the above-experimental results, it was found that hydroxyapatite nanocrystals can successfully be produced through wet precipitation method. The bulk Ca/Pmolar ratio of synthesized hydroxyapatite was determined as 1.71 that was higher than stoichiometric ratio (1.667) which is expected for a pure HAphase. Finally, transmission electron microscopic technique demonstrated that the crystallites of prepared powder were nanosized with a needle-like morphology.
- Hydroxyapatite
- Nanocrystals
- Precipitation
- Synthesis
How to Cite
References
[2]Jones F. Teeth and bones: Applications of surface science to dental materials and related biomaterials. Surf Sci Rep2001; 42: 75-205.
[3]Kikuchi M, Itoh S, Ichinose S, Shinomiya K,Tanaka J. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitroand its biological reactioninvivo. Biomaterials2001; 22: 1705-11.
[4]Schnettler R, Alt V, Dingeldein E, Pfefferle HJ,Kilian O, Meyer C, Heiss C, Wenisch S. Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants. Biomaterials2003; 24: 4603-8.
[5]Liou SC, Chen SY, Liu DM. Synthesis and char-acterization of needlelike apatitic nanocomposite with controlled aspect ratios. Biomaterials2003;24: 3981-8.
[6]Mavropoulos E, Rossi AM, Rocha NCC, Soares GA, Moreira JC, Moure GT. Dissolution of calcium-deficient hydroxyapatite synthesized at different conditions. Mater Charact2003; 5578:1-5.
[7]Li Y, Klein CPAT. Change and phase transition of need-like nonstochiometric apatite crystals. JMater Sci Mater Med1994; 5: 263-8.
[8]Fatehi K, Moztarzadeh F, Soalti-Hashjin M,Tahriri M, Rezvannia M, Ravarian R. In vitro biomimetic deposition of apatite on alkaline and heat treated Ti6A14Valloy surface. Bull Mat Sci 2008; 31; 101-8.
[9]Weiss P, Obadia L, Magne D, Bourges X, Rau C,Weitkamp T, Khairoun I, Bouler JM, Chappard D,Gauthier O, Daculsi G. Synchrotron X-ray micro-tomography (on a micron scale) provides three-dimensional imaging representation of bone ingrowth in calcium phosphate biomaterials.Biomaterials2203; 24: 4591-601.
[10]Afshar A, Ghorbani M, Ehsani N, Saeri MR,Sorrell CC. Some important factors in the wet precipitation process of hydroxyapatite. Mater Design2003; 24: 197-202.
[11]Morales JG, Burgues JT, Boix T, Fraile J,Clemente RR. Precipitation of stoichiometric hydroxyapatite by a continuous method. Cryst ResTechnol 2001; 36:15-26.
[12]Komath M, Varma HK. Development of a fully injectable calcium phosphate cement for orthopedic and dental applications. Bull Mater Sci 2003; 4: 415-22.
[13]Rameshbabu N, Kumar TSS, Rao KP. Synthesis of nanocrystalline fluorinated hydroxyapatite by microwave processing and its in vitro dissolution study. Bull Mater Sci 2006; 29: 611-5.
[14]Murray MGS, Wang J, Pontoon CB, Marquis PM. An improvement in processing of hydroxyapatite ceramics.J Mater Sci1995; 30:3061-74.
[15]Wei M, Evans JH, Bostrom T, Grondahl L.Synthesis and characterization of hydroxyapatite,fluoride-substituted hydroxyapatite and fluorapatite.J Mater Sci Mater Med 2003; 14:311-20.133
- Abstract Viewed: 1119 times
- IJPS_Volume 4_Issue 2_Pages 127-134 Downloaded: 395 times