Synthesis and Characterization of Some Transition Metal Complexes of Schiff Base Derived From 2, 4 – Dihydroxybenzaldehyde Synthesis and characterization of some transition
Iranian Journal of Pharmaceutical Sciences,
Vol. 15 No. 3 (2019),
1 July 2019
,
Page 29-40
https://doi.org/10.22037/ijps.v15.40475
Abstract
New N2O2 type Schiff base has been designed and synthesized by condensing 2, 4 dihydroxy benzaldehyde and α-naphthylamine in ethanol. Solid metal complexes of the schiff base with Cu(II), Ni(II) and Zn(II) metal ion were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis and ‘H NMR spectral studies. The data shows that the complexes have the composition of ML type.The UV-Visible and magnetic susceptibility data of the complexes suggest a square-planar geometry around the central metal ion except Zn (II) complex which has tetrahedral geometry. The redox behaviour of the complexes was studied by Cyclic Voltammetry. The in vitro activities of the compounds were tested against Staphylococcus, Bacillus subtilis, Escherichia Coli and Pseudomonas by well-diffusion method and antifungal of the compound were tested against fungi such as Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola by minimum inhibitory concentration. All the metal complexes showed stronger antifungal and antimicrobial activities than the free ligand.
Keywords:
- Schiff base
- 2
- 4 - dihydroxy benzaldehyde
- α-Naphthylamine
- Antifungal and Antimicrobial activity
How to Cite
Vijayalakshmi, M. . (2019). Synthesis and Characterization of Some Transition Metal Complexes of Schiff Base Derived From 2, 4 – Dihydroxybenzaldehyde: Synthesis and characterization of some transition. Iranian Journal of Pharmaceutical Sciences, 15(3), 29–40. https://doi.org/10.22037/ijps.v15.40475
References
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[25] Karipcin F, Akdogan G. B. Synthesis,characterization and properties of heteronuclear ruthenium (III) complexes of N, N′-o-bis [1-pdiphenylmethane-2-(arylamine)-1-ethiliden]-phenylenediamine quadridentate ligands. J. Incl. Phenom. Macrocycl. Chem. (2009) 64 (1-2): 183-192.
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[2] Katsuki T K. Catalytic asymmetric oxidations using optically active (salen) manganese (III) complexes as catalysts. Coord. Chem. Rev. (1995) 140:189-214
[3] Konsler R G, Karl J, Jacobsen E N. Cooperative Asymmetric Catalysis with Dimeric Salen Complexes. J. Am. Chem. Soc. (1998) 120 (41):10780-10781
[4] Wie P, Atwood D A. Bimetallic Borate Derivatives of the Salen Ligands. Inorg. Chem. (1997) 36 (18): 4060 - 4065.
[5] Kolb H C, VanNieuwenhze M S, Sharpless K B.Catalytic Asymmetric Dihydroxylation Chem. Rev.(1994) 94 (8): 2483 - 2547.
[6] Costamagna J, Vargas J, Latorre R, Avlvarado A,Mena G. Coordination compounds of copper, nickel and iron with Schiff bases derived from hydroxynaphthaldehydes and salicylaldehydes.Coord. Chem. Rev. (1992) 119: 67 -88.
[7] Marchetti F, Pettinari C, Pettinari R, Cingolani A,leonesi D, Lorenzotti A. Group 12 metal complexes of tetradentate N2O2–Schiff-base ligands incorporating pyrazole: Synthesis, characterisation and reactivity
toward S-donors, N-donors, copper and tin acceptors.Polyhedron. (1999) 18(23): 3041-3050.
[8] Pandeya S N, Sriram D, Nath G, Declearg E.Synthesis Antibacterial Antifungal and Anti HIV Activities of Schiff base and Manich Base Derived from Isatin Derivatives and N[4-4”-chlorophenyl) thiazol-2-yl] thiosemicarbazide. Eur. J. Pharm. Sci.(1999) 9 (1): 25-31.
[9] Sing D P, Kumark V. Template Synthesis of Macrocyclic Complexes of Co (II),Ni(II), Cu(II),Zn(II) and Cd(II):spectroscopic, Antimicrobial and Antifungal Studies, J. Serb. Chem. Soc. (2010) 75 (6):763-772.
[10] Panda A K, Dash D C, Mishra P, Mohanty H.Metallo ligands: Part V- Homo and Bimetallic trinuclear complexes of copper(II), Nickel(II) and Cobalt(II) with 1,8-di (2’-hydroxy-phenyl) 4,5-diphenyl-2,3,6,7-tetrazaoctan-1,3,5,7-tetraene. IndianJ. Chem. (1996) 35: 848-851.
[11] Mohamed G. G, Omar M. M, Ibrahim A. A.Preparation, characterization and biological activity of novel metal-NNNN donor Schiff base complexes.Spectrochimica Acta A. (2009)75 (2): 678-685.
[12] Marmur J. A procedure for the isolation of deoxyribonucleic acid from micro-organisms. J. Mol.Biol. (1961) 3 (2): 208-218.
[13] Reicmann M. E, Rice S. A, Thomas C. A, Doty P.A Further Examination of the Molecular Weight and Size of Deoxypentose Nucleic Acid. J. Am.Chem. Soc. (1954) 76: 3047-3053.
[14] Mathur S, Tabassum S. Template synthesis of novel carboxamide dinuclear copper (II) complex:spectral characterization and reactivity towards calfthymus DNA. Biometals. (2008) 21(3): 299-310.
[15] Raman N, Raja J, Sakthivel A. Synthesis,spectral characterization of Schiff base transition metal complexes: DNA cleavage and antimicrobial activity studies. J. Chem. Sci. (2007) 119 (4): 303-310.
[16] Sengottuvelan N, Manonmani J, Kandaswamy M. Synthesis of unsymmetrical compartmental oxime nickel (II) and copper (II) complexes: Spectral, Eleectrochemical and Magnetic studies. Polyhedron.
(2002) 21(27-28): 2767-2772
[17] Reddy V, Patil N, Angadi S D. Synthesis,Characterisation and Antimicrobial Activity of Cu(II),Co(II) and Ni(II) Complexes with O and N Donor Ligands, E-J. Chem. (2008) 5 (3): 577-583.
[18] Nakamato K. Infrared Spectra of inorganic and coordination Compounds, 2nd ed., John Wiley & Sons:New York (1970).
[19] Sharadha L N, Ganorkar M C. Synthesis and structural studies of VO (IV), Mn(II), Co(II), Ni(II) and Cu(II) complexes with new tridentate Schiff base having ONO and ONN donor systems. Indian J Chem. (1988) 27A: 617-621.
[20] Lever A B P. Inorganic Electronic Spectroscopy,1st ed., Amsterdam Elseveir: (1968) 249-360.
[21] Sivasankaran Nair M, Kalalakshmi G,Sankaranarayana Pillai M. Mixed ligand complex formation of copper (II) with 2, 5-diaminovaleric acid and some amino acids. J. Indian Chem. Soc. (1999) 76 (6): 310-311.
[22] Chandra S, Gupta, L K. Electronic, EPR,Magnetic and Mass Spectral Studies of Mono and Homo-Binuclear Co (II) and Cu(II) Complexes with a Novel Macrocyclic Ligand. Spectrochimica Acta A.Mol. Biomol. Spectroscopy. (2005) 62 (4-5): 1102-1106.
[23] Raman N, Raja S J, Joseph J, Sakthivel A.Designing, structural elucidation, comparison of DNA cleavage, and antibacterial activity of metal (II) complexes containing tetradentate Schiff base.Russ. J. Coord. Chem. (2008) 34 (11): 842-848.
[24]Badea M, Emandi A, Marinescu D, Cristurean E, Olar R, Braileanu A, Budrugeac P, Segal. Thermal stability of some azo-derivatives and their complexes. J. Therm. Anal. Calorim. (2003) 72 (2):525-531.
[25] Karipcin F, Akdogan G. B. Synthesis,characterization and properties of heteronuclear ruthenium (III) complexes of N, N′-o-bis [1-pdiphenylmethane-2-(arylamine)-1-ethiliden]-phenylenediamine quadridentate ligands. J. Incl. Phenom. Macrocycl. Chem. (2009) 64 (1-2): 183-192.
[26] Dutta R L, Syamal A. Elements of Magnatochemistry, 2ndEd., East west press:New Delhi (1996).
[27] Dharmaraj N, Viswanathamurthi P, Natarajan K. Ruthenium(II) complexes containing bidentate Schiff bases and their antifungal activity. Trans. Met.Chem. (2001) 26 (1-2): 105-109.
[28] Jain M, Gaur S, Singh V.P, Singh R.V.Organosilicon (IV) and organotin (IV) complexes as biocides and nematicides: synthetic, spectroscopic and biological studies of N∩N donor sulfonamide imine and its chelates. Appl. Organomet. Chem. (2004) 18 (2): 73-82.
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