Relationship between Caregivers' Beliefs about Medications and Medication Adherence in Children and Adolescents with Epilepsy
Advances in Nursing & Midwifery,
Vol. 32 No. 3 (2023),
15 July 2023
,
Page 23-29
https://doi.org/10.22037/anm.v32i3.43022
Abstract
Abstract
Introduction: Children with epilepsy need sustained drug treatment to achieve optimal and desired health outcomes. However, non-adherence to drug treatment is a common cause of adverse health outcomes in this population. This study aimed to investigate the relationship between caregivers' beliefs about antiepileptic drug therapy and adherence to medication in children and adolescents with epilepsy.
Methods: This correlational and cross-sectional study was conducted on 151 caregivers of children and adolescents with epilepsy aged between 2 months and 19 years old referred to the neurology clinic for epilepsy in Children's Hospital of Bandar Abbas, Iran. Data collection tools included demographic and general questionnaires; the Medication Adherence Report Scale (MARS) to assess medication adherence and the Beliefs about Medication Questionnaire (BMQ) for assessing the pharmaceutical beliefs of caregivers.
Results: Using quantile regression, there was no significant relationship between medication adherence and caregiver belief in the necessity of medications to control a child's epilepsy (P=0.38) and concern about the medications' side effects and efficacy (P=0.24). However, 47.7 % of caregivers reported full medication adherence.
Conclusions: Education about awareness of how to use and the effects of antiepileptic drugs is essential. By taking these actions, it is expected to increase medication adherence and following this, more appropriate control of epilepsy in children and adolescents.
- Medication Adherence
- Caregivers' Beliefs
- Epilepsy
How to Cite
References
Falsaperla R, D'Angelo G, Pratico AD, Mauceri L, Barbagallo M, Pavone P, et al. Ketogenic diet for infants with epilepsy: A literature review. Epilepsy Behav. 2020;112:107361. doi: 10.1016/j.yebeh.2020.107361 pmid: 33181904
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015;56(10):1515-23. doi: 10.1111/epi.13121 pmid: 26336950
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-82. doi: 10.1111/epi.12550 pmid: 24730690
Cansu A, Serdaroglu A, Yuksel D, Dogan V, Ozkan S, Hirfanoglu T, et al. Prevalence of some risk factors in children with epilepsy compared to their controls. Seizure. 2007;16(4):338-44. doi: 10.1016/j.seizure.2007.02.003 pmid: 17391991
Al-Aqeel S, Gershuni O, Al-Sabhan J, Hiligsmann M. Strategies for improving adherence to antiepileptic drug treatment in people with epilepsy. Cochrane Database Syst Rev. 2020;10(10):CD008312. doi: 10.1002/14651858.CD008312.pub4 pmid: 33089492
Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44-7. doi: 10.1111/j.1524-4733.2007.00213.x pmid: 18237359
Malek N, Heath CA, Greene J. A review of medication adherence in people with epilepsy. Acta Neurol Scand. 2017;135(5):507-15. doi: 10.1111/ane.12703 pmid: 27781263
Viswanathan M, Golin CE, Jones CD, Ashok M, Blalock S, Wines RC, et al. Closing the quality gap: revisiting the state of the science (vol. 4: medication adherence interventions: comparative effectiveness). Evid Rep Technol Assess (Full Rep). 2012(208.4):1-685. pmid: 24422970
Saengow VE, Chancharoenchai P, Saartying W, Pimpa W, Chotichanon N, Lewsirirat T, et al. Epilepsy video animation: Impact on knowledge and drug adherence in pediatric epilepsy patients and caregivers. Clin Neurol Neurosurg. 2018;172:59-61. doi: 10.1016/j.clineuro.2018.06.031 pmid: 29986196
Jimmy B, Jose J. Patient medication adherence: measures in daily practice. Oman Med J. 2011;26(3):155-9. doi: 10.5001/omj.2011.38 pmid: 22043406
Miner PJ, Alexander J, Ewing H, Gerace L. Caregivers' beliefs associated with medication adherence among children and adolescents with epilepsy. J Neurosci Nurs. 2013;45(4):211-8. doi: 10.1097/JNN.0b013e3182986127 pmid: 23812051
Shah NM, Hawwa AF, Millership JS, Collier PS, Ho P, Tan ML, et al. Adherence to antiepileptic medicines in children: a multiple-methods assessment involving dried blood spot sampling. Epilepsia. 2013;54(6):1020-7. doi: 10.1111/epi.12126 pmid: 23448146
Gollwitzer S, Kostev K, Hagge M, Lang J, Graf W, Hamer HM. Nonadherence to antiepileptic drugs in Germany: A retrospective, population-based study. Neurology. 2016;87(5):466-72. doi: 10.1212/WNL.0000000000002791 pmid: 27371490
Bayram S, Caliskan H. Evaluation of the Knowledge Level, Practice and Attitudes of the Caregivers on Ketogenic Diet Management. Arch Epilep. 2022;28(1):23-8. doi: 10.54614/ArchEpilepsy.2022.71602
Minaiyan M, Taheri M, Mirmoghtadaee P, Marasi M. Comparative Role of Demographic Factors and Patient's Belief about Prescribed Medicine on Adherence to Drug Treatment in Chronic Diseases (persian). J Isfahan Med Sch. 2011;29(156).
Yue Z, Li C, Weilin Q, Bin W. Application of the health belief model to improve the understanding of antihypertensive medication adherence among Chinese patients. Patient Educ Couns. 2015;98(5):669-73. doi: 10.1016/j.pec.2015.02.007 pmid: 25746128
Ge P, Liu ST, Xu SX, Zhang JZ, Lai YJ, Fu RC, et al. The Influence of Parents on Medication Adherence of Their Children in China: A Cross-Sectional Online Investigation Based on Health Belief Model. Front Public Health. 2022;10:845032. doi: 10.3389/fpubh.2022.845032 pmid: 35493366
Sharifzadeh G, Moodi M, Mazhari Majd H, Musaee I. Application of Health Belief Model in predicting preventive behaviors against cardiovascular disease in individuals at risk (persian). J Health Sci Technol. 2017;1(2):64-9.
Prasetya H, Murti B, Anantanyu S, Syamsulhadi M. The Effect of Hypnosis on Adherence to Antituberculosis Drugs Using the Health Belief Model. Int J Clin Exp Hypn. 2018;66(2):211-27. doi: 10.1080/00207144.2018.1421361 pmid: 29601278
Sajadi Hazaveh M, Shamsi M. Assesment of mothers' behavior about prevention of febrile seizure in children in Arak city:application of the health belief model (persian). JMJ. 2011;9(2):34-40. doi: 10.29252/jmj.9.2.34
Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses. Schizophr Res. 2000;42(3):241-7. doi: 10.1016/s0920-9964(99)00130-9 pmid: 10785582
Culig J, Leppee M. From Morisky to Hill-bone; self-reports scales for measuring adherence to medication. Coll Antropol. 2014;38(1):55-62.
Haughney J, Price D, Kaplan A, Chrystyn H, Horne R, May N, et al. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med. 2008;102(12):1681-93. doi: 10.1016/j.rmed.2008.08.003 pmid: 18815019
Baljani E, Rahimi Z, Heidari S, Azimpour A. The effect of self management interventions on medication adherence and life style in cardiovascular patients (persian). Avicenna J Nurs Midwife Care. 2012;20(3):58-68.
Horne R, Weinman J. Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res. 1999;47(6):555-67. doi: 10.1016/s0022-3999(99)00057-4 pmid: 10661603
Foot H, La Caze A, Gujral G, Cottrell N. The necessity-concerns framework predicts adherence to medication in multiple illness conditions: A meta-analysis. Patient Educ Couns. 2016;99(5):706-17. doi: 10.1016/j.pec.2015.11.004 pmid: 26613666
Hagell A, Coleman J, Brooks F. Key data on adolescence 2015. London: Association for Young People's Health.2015. 10 p.
Alsous M, Hamdan I, Saleh M, McElnay J, Horne R, Masri A. Predictors of nonadherence in children and adolescents with epilepsy: A multimethod assessment approach. Epilepsy Behav. 2018;85:205-11. doi: 10.1016/j.yebeh.2018.06.022 pmid: 30032809
Jones RM, Butler JA, Thomas VA, Peveler RC, Prevett M. Adherence to treatment in patients with epilepsy: associations with seizure control and illness beliefs. Seizure. 2006;15(7):504-8. doi: 10.1016/j.seizure.2006.06.003 pmid: 16861012
Kemp S, Feely M, Hay A, Wild H, Cooper C. Psychological factors and use of antiepileptic drugs: pilot work using an objective measure of adherence. Psychol Health Med. 2007;12(1):107-13. doi: 10.1080/14622200500358937 pmid: 17129938
Conn KM, Halterman JS, Fisher SG, Yoos HL, Chin NP, Szilagyi PG. Parental beliefs about medications and medication adherence among urban children with asthma. Ambul Pediatr. 2005;5(5):306-10. doi: 10.1367/A05-004R1.1 pmid: 16167856
Chapman SC, Horne R, Chater A, Hukins D, Smithson WH. Patients' perspectives on antiepileptic medication: relationships between beliefs about medicines and adherence among patients with epilepsy in UK primary care. Epilepsy Behav. 2014;31:312-20. doi: 10.1016/j.yebeh.2013.10.016 pmid: 24290250
Martin S, Elliott-DeSorbo DK, Calabrese S, Wolters PL, Roby G, Brennan T, et al. A comparison of adherence assessment methods utilized in the United States: perspectives of researchers, HIV-infected children, and their caregivers. AIDS Patient Care STDS. 2009;23(8):593-601. doi: 10.1089/apc.2009.0021 pmid: 19591601
Korkmaz MF, Erdem-Uzun M, Korkmaz M, Ekici A. Adherence to Antiepileptic Drugs and the Health Literacy of Caregivers in Childhood Epilepsy. P R Health Sci J. 2020;39(1):45-50. pmid: 32383567
Shetty J, Greene SA, Mesalles-Naranjo O, Kirkpatrick M. Adherence to antiepileptic drugs in children with epilepsy in a Scottish population cohort. Dev Med Child Neurol. 2016;58(5):469-74. doi: 10.1111/dmcn.12942 pmid: 26521659
Jacob L, Hamer HM, Kostev K. Adherence to antiepileptic drugs in children and adolescents: A retrospective study in primary care settings in Germany. Epilepsy Behav. 2017;75:36-41. doi: 10.1016/j.yebeh.2017.07.001 pmid: 28821006
Horne R, Graupner L, Frost S, Weinman J, Wright SM, Hankins M. Medicine in a multi-cultural society: the effect of cultural background on beliefs about medications. Soc Sci Med. 2004;59(6):1307-13. doi: 10.1016/j.socscimed.2004.01.009 pmid: 15210101
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