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学术急诊医学档案

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  3. 卷 3 编号 4 (2015): Autumn (November)
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卷 3 编号 4 (2015)

十一月 2015

The Effect of Blood Loss in the Presence and Absence of Severe Soft Tissue Injury on Hemodynamic and Metabolic Parameters; an Experimental study

  • Ali Mohammad Moradi
  • Omid Aj
  • Shahram Paydar
  • Farzaneh Ketabchi
  • Seyed Mostafa Sheid Moosavi
  • Shahram Bolandparvaz
  • Hamid Reza Abassi
  • Aryan Dokht Tamadon
  • Davood Mehrabani

学术急诊医学档案, 卷 3 编号 4 (2015), 1 十一月 2015 , 第 150-154 页
https://doi.org/10.22037/aaem.v3i4.293 已出版: 2018-12-26

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摘要

Introduction: The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. Methods: Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft tissue injury groups. The changes in blood pressure, central venous pressure (CVP) level, acidity (pH), and base excess were dynamically monitored and comparedsented. Results: Mean arterial blood pressure decreased significantly in hemorrhagic shock (df: 12; F=10.9; p<0.001) and severe soft tissue injury + hemorrhagic shock (df: 12; F=11.7; p<0.001) groups 15 minutes and 5 minutes after injury, respectively. A similar trend was observed in CVP in severe soft tissue injury + hemorrhagic shock group (df: 12; F=8.9; p<0.001). After 40 minutes, pH was significantly lower in hemorrhagic shock (df: 12; F=6.8; p=0.009) and severe soft tissue injury + hemorrhagic shock (df: 12; F=7.9; p=0.003) groups. Base excess changes during follow ups have a similar trend. (df: 12; F=11.3; p<0.001). Conclusion: The results of this study have shown that the effect of hemorrhage on the decrease of mean arterial blood pressure, CVP, pH, and base excess is the same in the presence or absence of soft tissue injury.
关键词:
  • Shock
  • hemorrhagic
  • soft tissue injuries
  • hemodynamics
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Moradi AM, Aj O, Paydar S, Ketabchi F, Sheid Moosavi SM, Bolandparvaz S, 等. The Effect of Blood Loss in the Presence and Absence of Severe Soft Tissue Injury on Hemodynamic and Metabolic Parameters; an Experimental study. Arch Acad Emerg Med [网际网络]. 2018年12月26日 [见引于 2026年7月8日];3(4):150-4. 载于: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/293
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参考

Letson HL, Dobson GP. Unexpected 100% survival following 60% blood loss using small-volume 7.5% NaCl with adenocaine and Mg2+ in the rat model of extreme hemorrhagic shock. Shock. 2011;36(6):586-94.

Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma Acute Care Surg. 2003;54(6):1127-30.

Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-54.

Saadat S, Yousefifard M, Asady H, Jafari AM, Fayaz M, Hosseini M. The Most Important Causes of Death in Iranian Population; a Retrospective Cohort Study. Emergency. 2014;3(1):16-21.

Harhangi B, Kompanje E, Leebeek F, Maas A. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien). 2008;150(2):165-75.

Donahue DL, Beck J, Fritz B, et al. Early Platelet Dysfunction in a Rodent Model of Blunt Traumatic Brain Injury Reflects the Acute Traumatic Coagulopathy Found in Humans. J Neurotrauma. 2014;31(4):404-10.

Kawasaki T, Okamoto K, Kawasaki C, Sata T. Thrombomodulin Improved Liver Injury, Coagulopathy, and Mortality in an Experimental Heatstroke Model in Mice. Anesth Analg. 2014;118(5):956-63.

Whelihan MF, Kiankhooy A, Brummel-Ziedins KE. Thrombin generation and fibrin clot formation under hypothermic conditions: An in vitro evaluation of tissue factor initiated whole blood coagulation. J Crit Care. 2014;29(1):24-30.

Little RA, Marshall HW, Kirkman E. Attenuation of the acute cardiovascular responses to haemorrhage by tissue injury in the conscious rat. Q J Exp Physiol. 1989;74(6):825-33.

Cherkas D. Traumatic hemorrhagic shock: advances in fluid management. Emerg Med Pract. 2011;13(11):1-19.

Spinella PC, Holcomb JB. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev. 2009;23(6):231-40.

Paydar S, Bazrafkan H, Golestani N, Roozbeh J, Akrami A, Moradi AM. Effects of Intravenous Fluid Therapy on Clinical and Biochemical Parameters of Trauma Patients. Emergency. 2014;2(2):90-5.

Hosseini M, Karami Z, Janzadenh A, et al. The Effect of Intrathecal Administration of Muscimol on Modulation of Neuropathic Pain Symptoms Resulting from Spinal Cord Injury; an Experimental Study. Emergency. 2014;2(4):151-7.

Ojaghi R, Sohanaki H, Ghasemi T, Keshavarz F, Yousefifard M, Sadeghipour H. Role of low-intensity laser therapy on naloxone-precipitated morphine withdrawal signs in mice: is nitric oxide a possible candidate mediator? Lasers Med Sci. 2014:1-5.

Ojaghi R, Sohanaki H, Ghasemi T, Keshavarz F, Yousefifard M, Sadeghipour H. Role of low-intensity laser therapy on naloxone-precipitated morphine withdrawal signs in mice: is nitric oxide a possible candidate mediator? Lasers Med Sci. 2014;29(5):1655-9.

Rixen D, Neugebauer EAM. Changing paradigms in animal models of traumatic/hemorrhagic shock. Eur J Trauma. 2004;30(5):279-88.

Angele MK, Schneider CP, Chaudry IH. Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care. 2008;12(4):218.

Badin J, Boulain T, Ehrmann S, et al. Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. Crit Care. 2011;15(3):R135.

Hierholzer C, Billiar TR. Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg. 2001;386(4):302-8.

Lomas-Niera JL, Perl M, Chung C-S, Ayala A. Shock and hemorrhage: an overview of animal models. Shock. 2005;24:33-9.

Tanideh N, Rokhsari P, Mehrabani D, et al. The Healing Effect of Licorice on Pseudomonas aeruginosa Infected Burn Wounds in Experimental Rat Model. World J Plast Surg. 2014;3(2):1-8.

Frink M, Andruszkow H, Zeckey C, Krettek C, Hildebrand F. Experimental trauma models: an update. Biomed Res Int. 2011;2011:1-15.

Rönn T, Lendemans S, de Groot H, Petrat F. A new model of severe hemorrhagic shock in rats. Comp Med. 2011;61(5):419-26.

Suzuki T, Kawasaki T, Choudhry MA, Chaudry IH. Role of PPARγ in the salutary effects of 17β-estradiol on Kupffer cell cytokine production following trauma-hemorrhage. J Cell Physiol. 2011;226(1):205-11.

Murao Y, Hata M, Ohnishi K, et al. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003;20(1):23-8.

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