Basic Reproduction Number (R0), Doubling Time, and Daily Growth Rate of the COVID-19 Epidemic: An Echological Study
学术急诊医学档案,
卷 12 编号 1 (2024),
1 一月 2024
,
第 e66 页
https://doi.org/10.22037/aaem.v12i1.2376
摘要
Introduction: In infectious diseases, there are essential indices used to describe the disease state. In this study, we estimated the basic reproduction number, R0, peak level, doubling time, and daily growth rate of COVID-19.
Methods: This ecological study was conducted in 5 provinces of Iran. The daily numbers of new COVID-19 cases from January 17 to February 8, 2020 were used to determine the basic reproduction number (R0), peak date, doubling time, and daily growth rates in all five provinces. A sensitivity analysis was conducted to estimate epidemiological parameters.
Result: The highest and lowest number of deaths were observed in Hamedan (657 deaths) and Chaharmahal and Bakhtiari (54 deaths) provinces, respectively. The doubling time of confirmed cases in Kermanshah and Hamedan ranged widely from 18.59 days (95% confidence interval (CI): 17.38, 20) to 76.66 days (95% CI: 56.36, 119.78). In addition, the highest daily growth rates of confirmed cases were observed in Kermanshah (0.037, 95% CI: 0.034, 0.039) and Sistan and Baluchestan (0.032, 95% CI: 0.030, 0.034) provinces.
Conclusion: In light of our findings, it is imperative to tailor containment strategies to the unique epidemiological profiles of each region in order to effectively mitigate the spread and impact of COVID-19. The wide variation in doubling times underscores the importance of flexibility in public health responses. By adapting measures to local conditions, we can better address the evolving dynamics of the pandemic and safeguard the well-being of communities.
- Reproduction Number
- COVID-19
- infectious disease transmission
- Epidemics
- Surveillance System
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参考
Ogata T, Tanaka H. Long Diagnostic Delay with Unknown Transmission Route Inversely Correlates with the Subsequent Doubling Time of Coronavirus Disease 2019 in Japan, February–March 2020. IJERPH . 2021;18(7):3377.
Pellis L, Scarabel F, Stage HB, Overton CE, Chappell LH, Fearon E, et al. Challenges in control of Covid-19: short doubling time and long delay to effect of interventions. Philos Trans R Soc Lond B Biol Sci . 2021;376(1829):20200264.
Tang B, Bragazzi NL, Li Q, Tang S, Xiao Y, Wu J. An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov). Infect Dis Model . 2020;5:248-55.
Liu Y, Gayle AA, Wilder-Smith A, Rocklöv J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med. 2020;27(2):taaa021.
Majumder MS, Mandl KD. Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility. Lancet Glob Health. 2020;8(5):e627-e30.
Zhou L, Liu J-M, Dong X-P, McGoogan JM, Wu Z-Y. COVID-19 seeding time and doubling time model: an early epidemic risk assessment tool. Infect Dis Poverty. 2020;9(1):76.
Turner K. Introduction to Infectious Disease Modelling. STI. 2010;87(1):21.
Lurie MN, Silva J, Yorlets RR, Tao J, Chan PA. Coronavirus disease 2019 epidemic doubling time in the United States before and during stay-at-home restrictions. J Infect Dis. 2020;222(10):1601-6.
Muniz-Rodriguez K, Chowell G, Cheung C-H, Jia D, Lai P-Y, Lee Y, et al. Doubling time of the COVID-19 epidemic by province, China. Emerg Infect Dis. 2020;26(8):1912.
D'Arienzo M, Coniglio A. Assessment of the SARS-CoV-2 basic reproduction number, R0, based on the early phase of COVID-19 outbreak in Italy. Biosaf Health. 2020;2(2):57-9.
Locatelli I, Trächsel B, Rousson V. Estimating the basic reproduction number for COVID-19 in Western Europe. PLoS One. 2021;16(3):e0248731.
Musa SS, Zhao S, Wang MH, Habib AG, Mustapha UT, He D. Estimation of exponential growth rate and basic reproduction number of the coronavirus disease 2019 (COVID-19) in Africa. Infect Dis Poverty. 2020;9(1):96.
Rahimi E, Hashemi Nazari SS, Mokhayeri Y, Sharhani A, Mohammadi R. Nine-month Trend of Time-Varying Reproduction Numbers of COVID-19 in West of Iran. J Res Health Sci. 2021;21(2):e00517
Azimi SS, Koohi F, Aghaali M, Nikbakht R, Mahdavi M, Mokhayeri Y, et al. Estimation of the basic reproduction number (?0) of the COVID-19 epidemic in Iran. Med J Islam Repub Iran. 2020;34:95.
Boelle PY OT, Obadia MT. Package ‘R0’. 2015.
Wallinga J, Lipsitch M. How generation intervals shape the relationship between growth rates and reproductive numbers. Proc Biol Sci. 2007;274(1609):599-604.
Marimuthu S, Joy M, Malavika B, Nadaraj A, Asirvatham ES, Jeyaseelan L. Modelling of reproduction number for COVID-19 in India and high incidence states. Clin Epidemiol Glob Health. 2021;9:57-61.
You C, Deng Y, Hu W, Sun J, Lin Q, Zhou F, et al. Estimation of the time-varying reproduction number of COVID-19 outbreak in China. Int J Hyg Environ Health. 2020;228:113555.
Shim E, Tariq A, Chowell G. Spatial variability in reproduction number and doubling time across two waves of the COVID-19 pandemic in South Korea, February to July, 2020. IJID. 2021;102:1-9.
Xu S, Clarke C, Shetterly S, Narwaney K. Estimating the growth rate and doubling time for short-term prediction and monitoring trend during the covid-19 pandemic with a sas macro. medRxiv. 2020.
Mazumder A, Arora M, Sra M, Gupta A, Behera P, Gupta M, et al. Geographical variation in case fatality rate and doubling time during the COVID-19 pandemic. Epidemiol Infect. 2020;148:e163.
Mishra D, Haleem A, Javaid M. Analysing the behaviour of doubling rates in 8 major countries affected by COVID-19 virus. J Oral Biol Craniofac Res. 2020;10(4):478-83.
Omori R, Mizumoto K, Chowell G. Changes in testing rates could mask the novel coronavirus disease (COVID-19) growth rate. Int J Infect Dis. 2020;94:116-8.
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