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学术急诊医学档案

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  3. 卷 5 编号 1 (2017): Continuous volume
  4. Case Report

卷 5 编号 1 (2017)

一月 2017

Head Trauma as a Precipitating Factor for Late-onset Leigh Syndrome: a Case Report

  • Farzad Ashrafi
  • Hossein Pakdaman
  • Mehran Arabahmadi
  • Behdad Behnam

学术急诊医学档案, 卷 5 编号 1 (2017), 1 一月 2017 , 第 e43 页
https://doi.org/10.22037/aaem.v5i1.168 已出版: 2017-01-14

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摘要

Leigh syndrome is a severe progressive neurodegenerative disorder with different clinical presentationsthat usually becomes apparent in the first year of life and rarely in late childhood and elderly years. It is causedby failure of mitochondrial respiratory chain and often results in regression of both mental and motor skills and might even lead to death. In some of the inherited neurodegenerative diseases like Alexander disease, head trauma is reported as a trigger for onset of the disease. We present a late onset Leigh syndrome in a 14-year-old girl whose symptoms were initiating following head trauma.
关键词:
  • Leigh disease
  • craniocerebral trauma
  • precipitating factors
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Ashrafi F, Pakdaman H, Arabahmadi M, Behnam B. Head Trauma as a Precipitating Factor for Late-onset Leigh Syndrome: a Case Report. Arch Acad Emerg Med [网际网络]. 2017年1月14日 [见引于 2026年7月7日];5(1):e43. 载于: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/168
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参考

Lake NJ, Compton AG, Rahman S, Thorburn DR. Leigh Syndrome: one disorder, more than 75 monogenic causes. Annals of neurology. 2016;79(2):190-203.

Sakushima K, Tsuji-Akimoto S, Niino M, Saitoh S, Yabe I, Sasaki H. Adult Leigh disease without failure to thrive. The neurologist. 2011;17(4):222-7.

Finsterer J. Leigh and Leigh-like syndrome in children and adults. Pediatric neurology. 2008;39(4):223-35.

Baertling F, Rodenburg RJ, Schaper J, Smeitink JA, Koopman WJ, Mayatepek E, et al. A guide to diagnosis and treatment of Leigh syndrome. Journal of Neurology, Neurosurgery & Psychiatry. 2014;85(3):257-65.

Lee JS, Kim H, Lim BC, Hwang H, Choi J, Kim KJ, et al. Leigh Syndrome in Childhood: Neurologic Progression and Functional Outcome. Journal of Clinical Neurology. 2016;12(2):181-7.

Rahman S, Blok R, Dahl HH, Danks D, Kirby D, Chow C, et al. Leigh syndrome: clinical features and biochemical and DNA abnormalities. Annals of neurology. 1996;39(3):343-51.

Namekawa M, Takiyama Y, Honda J, Shimazaki H, Sakoe K, Nakano I. Adult-onset Alexander disease with typical" tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature. BMC neurology. 2010;10(1):1.

Hayashi S, Okamoto K. [Leber's hereditary optic neuropathy after head trauma: a case report]. Rinsho shinkeigaku= Clinical neurology. 2011;51(10):781-3.

Wong VS, Langley B. Epigenetic changes following traumatic brain injury and their implications for outcome, recovery and therapy. Neuroscience letters. 2016;625:26-33.

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