Caffeine Intoxication in Pregnancy: Report of a case
Archives of Academic Emergency Medicine,
Vol. 7 No. 1 (2019),
Although fatalities due to caffeine intoxication are uncommon,a caffeine overdose may cause profound toxicity, resulting in tachycardia, arrhythmia, convulsions, vomiting, coma, and possibly death. In particular, high caffeine consumption while pregnant can cause increased fetal catecholamine levels, which could lead to increased fetal heart rate and placental vasoconstriction and impair fetal oxygenation. Therefore, caffeine intoxication in pregnant women should be treated immediately. Herein, we present a 33-year-old pregnant woman who was treated in our department afteringesting 4000mg of caffeine in an attempt to commit suicide. We successfully treated our patient, and she delivered a healthy baby at 38 weeks.
How to Cite
Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Addit Contam. 2003;20(1):1-30.
Silva AC, de Oliveira Ribeiro NP, de Mello Schier AR, Pereira VM, Vilarim MM, Pessoa TM, et al. Caffeine and suicide: a systematic review. CNS Neurol Disord Drug Targets. 2014;13(6):937-44.
Jabbar SB, Hanly MG. Fatal caffeine overdose: a case report and review of literature. Am J Forensic Med Pathol. 2013;34(4):321-4.
Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, et al. Maternal Caffeine Consumption during Pregnancy and Risk of Low Birth Weight: A Dose-Response Meta-Analysis of Observational Studies. PLoS One. 2015;10(7):e0132334.
Banerjee P, Ali Z, Levine B, Fowler DR. Fatal caffeine intoxication: a series of eight cases from 1999 to 2009. J Forensic Sci. 2014;59(3):865-8.
Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Caffeine-Related Deaths: Manner of Deaths and Categories at Risk. Nutrients. 2018;10(5).
Blanchard J, Sawers SJ. The absolute bioavailability of caffeine in man. Eur J Clin Pharmacol. 1983;24(1):93-8.
Ishigaki S, Fukasawa H, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R. Caffeine intoxication successfully treated by hemoperfusion and hemodialysis. Intern Med. 2014;53(23):2745-7.
Yu T, Campbell SC, Stockmann C, Tak C, Schoen K, Clark EA, et al. Pregnancyâ€induced changes in the pharmacokinetics of caffeine and its metabolites. The Journal of Clinical Pharmacology. 2016;56(5):590-6.
Resch BA, Papp JG. Effects of caffeine on the fetal heart. American Journal of Obstetrics & Gynecology. 1983;146(2):231-2.
Sonnier M, Cresteil T. Delayed ontogenesis of CYP1A2 in the human liver. European Journal of Biochemistry. 1998;251(3):893-8.
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