Serum and cerebrospinal fluid levels of S-100B is a biomarker for spinal cord injury; a systematic review and meta-analysis
Archives of Academic Emergency Medicine,
Vol. 7 No. 1 (2019),
1 January 2019
,
Page e19
https://doi.org/10.22037/aaem.v7i1.329
Abstract
Introduction: There is controversy regarding the value of serum or cerebrospinal fluid (CSF) levels of S100 calcium-binding protein B (S-100B) in spinal cord injury (SCI). For reaching a general conclusion, the present meta-analysis was designed aiming to evaluate the value of serum and CSF levels of S-100B protein in detecting the presence of SCI in animal studies.
Methods: An extensive search was performed in Medline, Embase, Scopus and Web of science databases. Screening articles, summarizing them and entering data to checklist and quality assessment of the mentioned articles were done by 2 independent reviewers. Data were analyzed and a pooled standardized mean difference (SMD) and 95% confidence interval (95% CI) were presented.
Results: Finally, the data of 7 articles were included in the meta-analysis. Serum level of S-100B had increased as a result of SCI. During the first 6 hours after injury, the level of this protein was very high (SMD=3.8; 95% CI: 2.6 to 5.1; p<0.0001), but as time passed the serum level of the protein had decreased (SMD=0.4; 95% CI: -1.2 to 2.0; p=0.65). In addition, CSF level of the mentioned protein was very high during the initial 6 hours after injury (SMD: 5.8; 95% CI: 3.6 to 8.0), and this elevated level was still observed until 12 hours after injury (SMD: 6.5; 95% CI: 3.7 to 9.3; p<0.0001).
Conclusion: The results of the present systematic review and meta-analysis show that measuring the level of S-100Î’ protein in serum and CSF has a potential value in diagnosis of SCI in animal models. This biomarker increases during the initial 6 hours following injury and remains high until 24 hours after that. However, more than 24 hours after the injury, serum level of this protein returns to the level of animals without SCI.
- S100 Calcium Binding Protein beta Subunit
- Spinal Cord Injuries
- Animals
- S100b protein
- rat
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References
Wyndaele M, Wyndaele J-J. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal cord. 2006;44(9):523.
Norton L. Spinal Cord Injury, Australia, 2007-08: Australian Institute of Health and Welfare Canberra; 2010.
Van Middendorp J, Hosman A, Pouw M, Van De Meent H. Is determination between complete and incomplete traumatic spinal cord injury clinically relevant? Validation of the ASIA sacral sparing criteria in a prospective cohort of 432 patients. Spinal Cord. 2009;47(11):809.
Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global burden of disease and risk factors: Oxford University Press New York; 2006.
van Middendorp JJ, Goss B, Urquhart S, Atresh S, Williams RP, Schuetz M. Diagnosis and prognosis of traumatic spinal cord injury. Global spine journal. 2011;1(01):001-8.
Tator CH. Review of treatment trials in humanspinal cord injury: issues, difficulties, and recommendations. Neurosurgery. 2006;59(5):957-87.
van Middendorp JJ, Sanchez GM, Burridge AL. The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries. European Spine Journal. 2010;19(11):1815-23.
Burns AS, Ditunno JF. Establishing prognosis and maximizing functional outcomes after spinal cord injury: a review of current and future directions in rehabilitation management. Spine. 2001;26(24S):S137-S45.
Kirshblum SC, Burns SP, Biering-Sorensen F, Donovan W, Graves DE, Jha A, et al. International standards for neurological classification of spinal cord injury (revised 2011). The journal of spinal cord medicine. 2011;34(6):535-46.
Kwon BK, Streijger F, Fallah N, Noonan VK, Bélanger LM, Ritchie L, et al. Cerebrospinal fluid biomarkers to stratify injury severity and predict outcome in human traumatic spinal cord injury. Journal of neurotrauma. 2017;34(3):567-80.
Selden NR, Quint DJ, Patel N, d'Arcy HS, Papadopoulos SM. Emergency magnetic resonance imaging of cervical spinal cord injuries: clinical correlation and prognosis. Neurosurgery. 1999;44(4):785-92.
Mahmood N, Kadavigere R, Avinash K, Rao V. Magnetic resonance imaging in acute cervical spinal cord injury: a correlative study on spinal cord changes and 1 month motor recovery. Spinal Cord. 2009;47(6):504-.
van Middendorp J. On the injuries of the vertebrae and spinal marrow: prognostic factors & classifications: [Sl: sn]; 2010.
Jacobs SR, Yeaney NK, Herbison GJ, Ditunno JF. Future ambulation prognosis as predicted by somatosensory evoked potentials in motor complete and incomplete quadriplegia. Archives of physical medicine and rehabilitation. 1995;76(7):635-41.
Curt A, Keck ME, Dietz V. Functional outcome following spinal cord injury: significance of motor-evoked potentials and ASIA scores. Archives of physical medicine and rehabilitation. 1998;79(1):81-6.
Curt A, Dietz V. Electrophysiological recordings in patients with spinal cord injury: significance for predicting outcome. Spinal cord. 1999;37(3).
Kwon BK, Casha S, Hurlbert RJ, Yong VW. Inflammatory and structural biomarkers in acute traumatic spinal cord injury. Clinical chemistry and laboratory medicine. 2011;49(3):425-33.
Yokobori S, Zhang Z, Moghieb A, Mondello S, Gajavelli S, Dietrich WD, et al. Acute diagnostic biomarkers for spinal cord injury: review of the literature and preliminary research report. World neurosurgery. 2015;83(5):867-78.
Wolf H, Krall C, Pajenda G, Leitgeb J, Bukaty AJ, Hajdu S, et al. Alterations of the biomarker S-100B and NSE in patients with acute vertebral spine fractures. The spine journal : official journal of the North American Spine Society. 2014;14(12):2918-22.
Mazzone GL, Nistri A. S100beta as an early biomarker of excitotoxic damage in spinal cord organotypic cultures. Journal of neurochemistry. 2014;130(4):598-604.
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. Jama. 2000;283(15):2008-12.
Hassanzadehâ€Rad A, Yousefifard M, Katal S, Asady H, Fardâ€Esfahani A, Moghadas Jafari A, et al. The value of 18Fâ€fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and metaâ€analysis. Journal of gastroenterology and hepatology. 2016;31(5):929-35.
Yousefifard M, Baikpour M, Ghelichkhani P, Asady H, Nia KS, Jafari AM, et al. Screening Performance Characteristic of Ultrasonography and Radiography in Detection of Pleural Effusion; a Meta-Analysis. Emergency. 2016;4(1):1.
Hosseini M, Yousefifard M, Aziznejad H, Nasirinezhad F. The Effect of Bone Marrow–Derived Mesenchymal Stem Cell Transplantation on Allodynia and Hyperalgesia in Neuropathic Animals: A Systematic Review with Meta-Analysis. Biology of Blood and Marrow Transplantation. 2015;21(9):1537-44.
Hosseini M, Ghelichkhani P, Baikpour M, Tafakhori A, Asady H, Ghanbari MJH, et al. Diagnostic Accuracy of Ultrasonography and Radiography in Detection of Pulmonary Contusion; a Systematic Review and Meta-Analysis. Emergency. 2015;3(4):127.
Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions: John Wiley & Sons; 2011.
Hosseini M, Yousefifard M, Baikpour M, Rahimi-Movaghar V, Nasirinezhad F, Younesian S, et al. The efficacy of Schwann cell transplantation on motor function recovery after spinal cord injuries in animal models: a systematic review and meta-analysis. Journal of chemical neuroanatomy. 2016;78:102-11.
Ebrahimi A, Yousefifard M, Kazemi HM, Rasouli HR, Asady H, Jafari AM, et al. Diagnostic accuracy of chest ultrasonography versus chest radiography for identification of pneumothorax: a systematic review and meta-analysis. Tanaffos. 2014;13(4):29-40.
Yousefifard M, Rahimi-Movaghar V, Nasirinezhad F, Baikpour M, Safari S, Saadat S, et al. Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis. Neuroscience. 2016;322:377-97.
Yousefifard M, Baikpour M, Ghelichkhani P, Asady H, Darafarin A, Esfahani MRA, et al. Comparison of Ultrasonography and Radiography in Detection of Thoracic Bone Fractures; a Systematic Review and Meta-Analysis. Emergency. 2016;4(2):55.
Rahimi-Movaghar V, Yousefifard M, Ghelichkhani P, Baikpour M, Tafakhori A, Asady H, et al. Application of Ultrasonography and Radiography in Detection of Hemothorax: a Systematic Review and Meta-Analysis. EMERGENCY-An Academic Emergency Medicine Journal. 2016;4(3):116-26.
Rahimi-Movagha V, Yousefifard M, Ghelichkhani P, Baikpour M, Tafakhori A, Asady H, et al. Application of ultrasonography and radiography in detection of hemothorax: a systematic review and meta-analysis. Emergency. 2015;4(0):9681-.
Izadi A, Yousefifard M, Nakhjavan-Shahraki B, Baikpour M, Mirzay Razaz J, Hosseini M. Diagnostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Detection of Pediatric Acute Kidney Injury; a Systematic Review and Meta-Analysis. International Journal of Pediatrics. 2016;4(11):3875-95.
Izadi A, Yousefifard M, Nakhjavan-Shahraki B, Baikpour M, Mirzay Razaz J, Ataei N, et al. Value of plasma/serum neutrophil gelatinase-associated lipocalin in detection of pediatric acute kidney injury; a systematic review and meta-analysis. International Journal of Pediatrics. 2016;4(11):3815-36.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of internal medicine. 2009;151(4):264-9.
Sistrom CL, Mergo PJ. A simple method for obtaining original data from published graphs and plots. American Journal of Roentgenology. 2000;174(5):1241-4.
Yousefifard M, Rahimi-Movaghar V, Nasirinezhad F, Baikpour M, Safari S, Saadat S, et al. Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis. Neuroscience. 2016;322:377-97.
Hassannejad Z, Sharif-Alhoseini M, Shakouri-Motlagh A, Vahedi F, Zadegan SA, Mokhatab M, et al. Potential variables affecting the quality of animal studies regarding pathophysiology of traumatic spinal cord injuries. Spinal cord. 2016;54(8):579-83.
Cao F, Yang XF, Liu WG, Hu WW, Li G, Zheng XJ, et al. Elevation of neuron-specific enolase and S-100beta protein level in experimental acute spinal cord injury. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2008;15(5):541-4.
Ersahin M, Toklu HZ, Erzik C, Akakin D, Tetik S, Sener G, et al. Ghrelin alleviates spinal cord injury in rats via its anti-inflammatory effects. Turkish neurosurgery. 2011;21(4):599-605.
Loy DN, Sroufe AE, Pelt JL, Burke DA, Cao QL, Talbott JF, et al. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta. Neurosurgery. 2005;56(2):391-7; discussion -7.
Ma J, Novikov LN, Karlsson K, Kellerth JO, Wiberg M. Plexus avulsion and spinal cord injury increase the serum concentration of S-100 protein: an experimental study in rats. Scandinavian journal of plastic and reconstructive surgery and hand surgery. 2001;35(4):355-9.
Schultke E, Griebel RW, Juurlink BH. Quercetin administration after spinal cord trauma changes S-100 levels. The Canadian journal of neurological sciences Le journal canadien des sciences neurologiques. 2010;37(2):223-8.
Yang Z, Bramlett HM, Moghieb A, Yu D, Wang P, Lin F, et al. Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers. Molecular neurobiology. 2017.
Zhang B, Huang Y, Su Z, Wang S, Wang S, Wang J, et al. Neurological, functional, and biomechanical characteristics after high-velocity behind armor blunt trauma of the spine. The Journal of trauma. 2011;71(6):1680-8.
Fassbender K, Schmidt R, Schreiner A, Fatar M, Mühlhauser F, Daffertshofer M, et al. Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke. Journal of the neurological sciences. 1997;148(1):101-5.
Woertgen C, Rothoerl R, Holzschuh M, Metz C, Brawanski A. Comparison of serial S-100 and NSE serum measurements after severe head injury. Acta neurochirurgica. 1997;139(12):1161-5.
Salehpoor F, Meshkini A, Shokouhi G, Aghazade J, Lotfinia I, Shakeri M, et al. Prognostic serum factors in traumatic brian injury: a systematic review. Iranian journal of neurosurgery. 2015;1(1):10-22.
Thelin EP, Zeiler FA, Ercole A, Mondello S, Buki A, Bellander BM, et al. Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review. Frontiers in neurology. 2017;8:300.
Lugones M, Parkin G, Bjelosevic S, Takagi M, Clarke C, Anderson V, et al. Blood biomarkers in paediatric mild traumatic brain injury: a systematic review. Neuroscience & Biobehavioral Reviews. 2018.
Chen A, Springer JE. Neuroproteomic methods in spinal cord injury. Neuroproteomics: Springer; 2009. p. 57-67.
Guéz M, Hildingsson C, Rosengren L, Karlsson K, Toolanen G. Nervous tissue damage markers in cerebrospinal fluid after cervical spine injuries and whiplash trauma. Journal of neurotrauma. 2003;20(9):853-8.
Kwon BK, Stammers AM, Belanger LM, Bernardo A, Chan D, Bishop CM, et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. Journal of neurotrauma. 2010;27(4):669-82.
Dumont AS, Dumont RJ, Oskouian RJ. Will improved understanding of the pathophysiological mechanisms involved in acute spinal cord injury improve the potential for therapeutic intervention? Current opinion in neurology. 2002;15(6):713-20.
Oyinbo CA. Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. Acta Neurobiol Exp (Wars). 2011;71(2):281-99.
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