High-Dose Vitamin C in the Treatment of Covid-19 Patients in Intensive Care Unit; A Letter to the Editor
Archives of Academic Emergency Medicine,
Vol. 12 No. 1 (2024),
1 January 2024
,
Page e41
https://doi.org/10.22037/aaem.v12i1.2233
Abstract
Vitamin C is a powerful antioxidant, which helps to improve the body's immune system. The antioxidant property of vitamin C reduces inflammation and improves the body's defense function against pathogens. In an interventional study, a total of 210 COVID-19 patients admitted to the intensive care units were randomly divided into two control and intervention groups. The intervention group received a treatment protocol including a high-dose vitamin C (12 g of vitamin C via a pump within four hours, which was repeated every 12 hours) for a week. About 60% of the patients in both groups died with no significant difference in the mortality rate between the two groups (p = 0.747). There was no improvement in the length of hospital stay, the degree of O2 saturation, and the mortality rate of the patients. No severe adverse effects were shown with this dose of vitamin C in ICU patients.
- Vitamin C
- COVID-19 disease
- Intensive care unit
- critical care
How to Cite
References
Shahsavarinia K, Ghojazadeh M, Ghabousian A, Hatefnia F, Soleimanpour M, Soleimanpour H. An umbrella review of clinical efficacy and adverse cardiac events associated with hydroxychloroquine or chloroquine with or without azithromycin in patients with COVID-19. Anesthesiology and Pain Medicine. 2021;11(4).
Bagi HM, Soleimanpour M, Abdollahi F, Soleimanpour H. Evaluation of clinical outcomes of patients with mild symptoms of coronavirus disease 2019 (COVID-19) discharged from the emergency department. PloS one. 2021;16(10):e0258697.
Tahsini Tekantapeh S, Ghojazadeh M, Ghamari AA, Mohammadi A, Soleimanpour H. Therapeutic and anti-inflammatory effects of baricitinib on mortality, ICU transfer, clinical improvement, and CRS-related laboratory parameters of hospitalized patients with moderate to severe COVID-19 pneumonia: a systematic review and meta-analysis. Expert Review of Respiratory Medicine. 2022;16(10):1109-32.
Shahsavarinia K, Amiri P, Mousavi Z, Gilani N, Saadati M, Soleimanpour H. Prediction of PTSD related to COVID-19 in emergency staff based on the components of self-compassion and perceived social support. BMC psychiatry. 2022;22(1):368.
Coronavirus disease 2019 (COVID-19) situation report – 153: World Health organization Ahwwiedn-c-s-r.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020;395(10223):497-506.
Tzotzos SJ, Fischer B, Fischer H, Zeitlinger M. Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey. Critical Care. 2020;24:1-4.
Soleimanpour H. The magical role of vitamin C on adrenal insufficiency subsequent to etomidate administration: ongoing challenges in the management of trauma patients. Int J Drug Res Clin. 2023;1:e1.
Panahi JR, Paknezhad SP, Vahedi A, Shahsavarinia K, Laleh MR, Soleimanpour H. Effect of vitamin C on adrenal suppression following etomidate for rapid sequence induction in trauma patients: a randomized clinical trial. BMC anesthesiology. 2023;23(1):104.
Liu F, Zhu Y, Zhang J, Li Y, Peng Z. Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial. BMJ open. 2020;10(7):e039519.
de Grooth H-J, Manubulu-Choo W-P, Zandvliet AS, Spoelstra-de Man AM, Girbes AR, Swart EL, et al. Vitamin C pharmacokinetics in critically ill patients: a randomized trial of four IV regimens. Chest. 2018;153(6):1368-77.
Mahmoodpoor A, Shadvar K, Sanaie S, Hadipoor MR, Pourmoghaddam MA, Saghaleini SH. Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study. BMC Infectious Diseases. 2021;21:1-7.
Milani GP, Macchi M, Guz-Mark A. Vitamin C in the Treatment of COVID-19. Nutrients. 2021;13(4):1172.
- Abstract Viewed: 216 times
- pdf Downloaded: 638 times