SBMU Journals
  • New Submission
  • Register
  • Login
  • English
    • 简体中文

Archives of Academic Emergency Medicine

  • Home
  • About
    • Policies
    • Editorial Team
    • Reviewer guideline
    • Statistics
    • Contact
  • Issues
    • Current
    • Archives
  • Announcements
  • Indexing/Abstracting
  • For authors
    • New Submission
    • Author guidelines
    • Article withdrawal
    • Peer review process
    • FAQ
  • Ethics
    • Ethical requirements
    • Plagiarism Policy
    • Authorship conflicts
    • Malpractice statements
    • Copyright Notice
    • Intellectual properties
    • Privacy Statement
    • Artificial intelligence & Authorship
    • Retraction Cosiderations
Advanced Search
  1. Home
  2. Archives
  3. Vol. 11 No. 1 (2023): Continuous volume
  4. Original/Research Article

Vol. 11 No. 1 (2023)

November 2022

The Effect of Intravenous Metoclopramide on Gastric Emptying of Opium-dependent Patients based on Ultrasonographic Criteria; a Case-control Study

  • Faramarz Mosaffa
  • Ali Arhami Dolatabadi
  • Masoomeh Raoufi
  • Faezeh Golpour
  • Mahshid Ghasemi
  • Mohammad Javad Yazdipoor
  • Elham Memary

Archives of Academic Emergency Medicine, Vol. 11 No. 1 (2023), 15 November 2022 , Page e6
https://doi.org/10.22037/aaem.v11i1.1892 Published: 2023-01-01

  • View Article
  • Download
  • Cite
  • References
  • Statastics
  • Share

Abstract

Introduction: Induction of anesthesia for emergency procedures, without prior gastric preparation and incomplete fasting, is associated with the risk of reflux of stomach contents and aspiration. This study aimed to evaluate the effect of intravenous (IV) metoclopramide administration on gastric emptying in opium users, candidate for procedural sedation and analgesia (PSA).

Methods: In the present case-control study, opium-dependent (case) and non-dependent (control) patients in need of PSA were administered with 10 mg IV metoclopramide after undergoing gastric ultrasonography for determination of its area and contents. Then, 30 minutes after the administration of metoclopramide, the area and contents of the stomach were measured again and compared with the measures obtained before the intervention.

Results: 135 patients were evaluated in three groups of 45, including the case, control, and placebo groups. The three groups were similar regarding mean age (p = 0.068), sex (p = 0.067), weight (p = 0.596), height (p = 0.671), body mass index (BMI) (p = 0.877), duration of fasting (p = 0.596), and type of gastric contents (p = 0.124). Mean antral cross-sectional area (CSA) of the study participants in the case, control, and placebo groups before the administration of the drug was 8.49 ± 1.40, 8.31 ± 2.56, and 6.56 ± 1.72 cm2, respectively. Mean gastric area in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention. Mean antral gastric grade of gastric contents in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention.

Conclusion: It seems that metoclopramide administration in opium users in need of PSA leads to a significant decrease in mean gastric area and increases gastric emptying.

Keywords:
  • Deep Sedation
  • Emergency Treatment
  • Anesthesia
  • Respiratory Aspiration
  • Ultrasonography
  • Clinical Trial
  • pdf

How to Cite

1.
Mosaffa F, Arhami Dolatabadi A, Raoufi M, Golpour F, Ghasemi M, Yazdipoor MJ, Memary E. The Effect of Intravenous Metoclopramide on Gastric Emptying of Opium-dependent Patients based on Ultrasonographic Criteria; a Case-control Study . Arch Acad Emerg Med [Internet]. 2023 Jan. 1 [cited 2025 May 24];11(1):e6. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1892
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

Kluger M, Short T. Aspiration during anaesthesia: a review of 133 cases from the Australian Anaesthetic Incident Monitoring Study (AIMS). Anaesthesia. 1999;54(1):19-26.

Kluger MT, Culwick MD, Moore MR, Merry AF. Aspiration during anaesthesia in the first 4000 incidents reported to webAIRS. Anaesthesia and intensive care. 2019;47(5):442-51.

Cook T. Strategies for the prevention of airway complications–a narrative review. Anaesthesia. 2018;73(1):93-111.

Hewson DW, Moppett I. Preoperative fasting and prevention of pulmonary aspiration in adults: research feast, quality improvement famine. British journal of anaesthesia. 2020;124(4):361-3.

Nason KS. Acute intraoperative pulmonary aspiration. Thoracic surgery clinics. 2015;25(3):301.

Robinson M, Davidson A. Aspiration under anaesthesia: risk assessment and decision-making. Continuing Education in Anaesthesia Critical Care & Pain. 2014;14(4):171-5.

Perlas A, Mitsakakis N, Liu L, Cino M, Haldipur N, Davis L, et al. Validation of a mathematical model for ultrasound assessment of gastric volume by gastroscopic examination. Anesthesia & Analgesia. 2013;116(2):357-63.

Sayyadi S, Raoufi M, Dolatabadi AA, Rostami M, Memary E. Ultrasonographic Assessment of Metoclopramide Administration Effectiveness in Accelerating Gastric Emptying Before Urgent Surgery in Patients with Insufficient NPO Time. Anesthesiology and Pain Medicine. 2020;10(5).

Abdolrazaghnejad A, Banaie M, Safdari M. Ultrasonography in emergency department; a diagnostic tool for better examination and decision-making. Advanced journal of emergency medicine. 2018;2(1).

Nasr-Esfahani M, Behravan M, Esmailian M. The Correlation between Ultrasonographic Gastric Antral Area and Vomiting in Patients undergoing Procedural Sedation and Analgesia. Frontiers in Emergency Medicine. 2020;4(4):e83-e.

Bouvet L, Chassard D. Ultrasound assessment of gastric contents in emergency patients examined in the full supine position: an appropriate composite ultrasound grading scale can finally be proposed. Springer; 2020. p. 865-8.

Mahmoud Reza K, Masour Reza S, Farhad Z. < The> usage of opioids and their adverse effects in gastrointestinal practice: a review. 2013.

Brock C, Olesen SS, Olesen AE, Frøkjaer JB, Andresen T, Drewes AM. Opioid-induced bowel dysfunction. Drugs. 2012;72(14):1847-65.

Farmer AD, Drewes AM, Chiarioni G, De Giorgio R, O'Brien T, Morlion B, et al. Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European gastroenterology journal. 2019;7(1):7-20.

Camilleri M, Atieh J. New developments in prokinetic therapy for gastric motility disorders. Frontiers in Pharmacology. 2021:2216.

Vijayvargiya P, Camilleri M, Chedid V, Mandawat A, Erwin PJ, Murad MH. Effects of promotility agents on gastric emptying and symptoms: a systematic review and meta-analysis. Gastroenterology. 2019;156(6):1650-60.

  • Abstract Viewed: 514 times
  • pdf Downloaded: 793 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram

Make a Submission

Make a Submission

SJR

SCImago Journal & Country Rank

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact

This journal is distributed under the terms of CC BY-NC 3.0. Design and publishing by SBMU journals. All credits and honors to PKP for their OJS. 

 Sitemap | ISSN-ONLINE: 2645-4904

Support Contact: ma.saghaei63@gmail.com

With the goal of net zero carbon emissions, this journal is published only in electronic format.

Powered by OJSPlus