Oral Midazolam Vs Promethazine as Pre Sedation Medication in Pediatric Dentistry
Journal of Dental School, Shahid Beheshti University of Medical Sciences,
Vol. 36 No. 2 (2018),
4 Esfand 2019
,
Page 47-50
https://doi.org/10.22037/jds.v36i2.24547
Abstract
Objectives Pre- and post-sedation effect of oral Midazolam to promethazine in2-6 yrs old fearful children for dental treatment
Methods This randomized clinical trial was carried out on a group of 26 children aged 2-6 years referred to the dental school due to their fear and multiple dental needs. Patients were selected from ASA I or II classification and scored 1 in Frankl Behavior scale. Each patient was scheduled for two subsequent visits to receive one of the two pre medications before IV sedation. Each patient served as self-control and randomly assigned to either group A: receiving Midazolam oral as premed in 1st visit or group B: receiving Promethazine oral as the premed in 1st visit. Six hour NPO was instructed prior to sedation visit. Monitoring vital signs were conducted at every 15 minutes starting with base line before any drug administration. Sedation score was recorded using Houpt Sedation scale. Post sedation problems were recorded by operator. Data were analyzed using Student t test and Kruskal Wallis.
Results No significant difference was noted between the patient perceptions at the two different visits. Children did not show a significant difference on symptoms such as Crying, Movement, Sleep and overall behavior in two visits at the first 15 minutes of sedative injection. Post-operative complications were having no significant difference. Lower sickness and vomiting were reported following promethazine intake.
Conclusion Promethazine seems to be as effective and as acceptable premedication as Midazolam in pediatric dentistry.
- Promethazine
- Midazolam
- Oral premedication
- IV Sedation
- Children
- teeth
How to Cite
References
Paterson SA, Tahmassebi JF. Pediatric dentistry in the new millenium.3 Use of inhalation sedation in pediatric dentistry. Dent Update 2003 Sep;30(7):350-356,358.
Beirami F ,Khoshfetrat M ,Babaiyan S, Ansari-Moghadam A .Efficacy of different dose of oral midazolam for preoperation sedation of children .Zahedan Res Med Sci 2016: May 18(5):e6671.
Gazal G , Farid WM, Zafar MS, Al-Samadani KH . Pain and anxiety management for pediatric dental procedure using various combinations of sedative drugs: A review. Saudi Pharm J 2016 Jul 24(4):379-385.
Araứjo JO, Motta RHL, Bergamaschi CC, Guimaräes CC, Ramacciato JC, de Ardrade NK, Fiqueiró MF, Lopes LC. Effectiveness and safely of oral sedation in adult patients undergoing dental procedures: protocol for a systematic review. BMJ Open 2018 Jan 13:8(1): e017681.
Bagheri M. The use of midazolam in pediatric dentistry: A review of the Literature. Razavi Int J Med.2014; Aug 2(3): e16913
Primosch RE, Guelmann M. Comparisons of drops versus spray administration of intranasal midazolam in two and three year old children for dental sedation. Pediatr Dent 2005 Sep-Oct; 27(5): 401-408.
Golpayegani MV, Dehghan F, Ansari G, Shayeghi S. Comparison of oral Midazolam-Ketamine and Midazolam-Promethazine as sedative agents in pediatric dentistry. Dent Res J (Isfahan) 2012 Jan; 9(1): 36-40.
Nadri S, Mahmoudvand H, Taee N, Anbari K, Beiranvand S. Promethazine and oral Midazolam preanesthetic children medication. Pediatr Emerg Care 2018 Jan 15.
Damle SG, Gandhi M, Laheri V. Comparison of oral ketamine and oral midazolam as sedative agent in pediatric dentistry. J Indian Soc Pedod Prev Dent 2008 Sep; 26(3):97-101.
Torres-Pérez J, Tapia-Garcia I, Rosales-Berber MA, Hernandez-Sierra JF, Pozos-Guillén J. Comparison of three conscious sedation regimen for pediatric dental patients. J Clin Pediatr Dent 2007 Spring;31(3):183-6.
Sheroan MM, Dilley DC, Lucas WJ, Vann WF. A prospective study of 2 sedation regimens in children: Chloral hydrate, Meperidine and Hydroxyzine versus Midazolam, Meperidine and Hydroxyzine. Anesth Prog 2006 Fall; 53(3): 83-90.
Mathai A, Nazareth M, Raju RS. Pre-anesthetic sedation of preschool children: Comparison of intranasal midazolam vs oral promethazine. Anesth Essays Res 2011 Jan-Jun; 5(1): 67-71.
Fallah R, Alaei A, Akhavan Karbasi S, Shajari A. Chloral Hydrate, chloral hydrate-Promethazine and Chloral hydrate-Hydroxyzine efficacy in encephalography Sedation. Indian J Pediatr 2014 Jun; 81(6): 541-6.
Behetwar SK, Panadey RK, Saksena AK, Chandra G. A comparative evaluation on intranasal midazolam,ketamine and their combination for sedation in young uncooperative pediatric dental patient:A triple blind randomized crossover trial. J Clin Pediatr Dent 2011 Summer; 35(4):415-420.
Bui T, Redden RJ, Murphy S. A comparison study between Ketamine and KetaminePromethazine combination for oral sedation in pediatric dental patients. Anesth Prog 2002 Winter; 49(1):14-18.
Dallman JA, Ignelzi MA Jr, Briskie DM. Comparing the safety, efficacy and recovery of intranasal Midazolam vs. oral chloral hydrate and Promethazine. Pediatr Dent 2001 Sep-Oct;23(1):424-30.
Derakhshan H, Modanlookordi M, Afshin A, Shahrami A. A comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. Iran J Child Neural 2013 Spring; 7(2):11-16.
Singh N, Pandey RK, Saksena AK, Jaiswal JN. A comparative evaluation of oral midazolam with oral sedatives as premedication in pediatric dentistry. J Clin Pediatr Dent 2002 Winter; 26(2):161-164.
Pfeil N, Uhlig U, Kostev K, Carius R, Schroder H, Kiess W, et al. Antiemetic medication in children with presumed infectious gastroenteritis, Pharmacoepidemiology in Europe and Northern America. J Pediatr 2008: 153(5): 659-662.
Barzegari H, Zohrevandi B, Masoumi K, Forouzan A, Darian AA, Khosravi S. Comparison of oral Midazolam and Promethazine with oral Midazolam alone for sedating children during computed tomography. Emerg (Tehran). 2015 Summer; 3(3):109-13
Razieh F, Sharam J, Motahhareh G, Sedighah AK, Mohammad-Hosein J. Efficacy of chloral hydrate and Promethazine for sedation during electroencephalography in children; A randomised clinical trial. Iran J Pediatr. 2013 Feb; 23(1):27-31.
Marume A, Muvirimi TG, Chitindingu K, Mutingwende I. Inappropriate use of promethazine and promethazine-containing products in children under the age of three years in Harare, Zimbabwe. Cent Afr J Med. 2011 Sep-Dec; 57(9-12):39-43.
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