Effects of Sertraline on Spermatogenesis of Male Rats and its Reversibility after Terminating the Drug
Urology Journal,
Vol. 18 No. 04 (2021),
20 September 2021
,
Page 434-438
https://doi.org/10.22037/uj.v18i04.6458
Abstract
Purpose: The purpose of this research was to studding the effects of Sertraline on spermatogenesis of male rats and whether these probable effects are constant or provisional after terminating the drug.
Materials and Methods: In this study, 32 two-month old male Wistar albino rats were equally divided into the Sertraline-treated and the control groups. The drug group was gavaged with Sertraline daily while the control group was gavaged with water at the same volume. After 80 days, half of the rats in each group were selected randomly for hormonal evaluations and bilateral orchiectomy. Histological and hormonal evaluations were performed. The remaining half of rats were kept alive for 90 more days without intervention and then underwent hormonal evaluation and bilateral orchiectomy in a similar fashion.
Results: There was no difference between the testes histology and pathology of the sertraline-treated and the control groups. There was a significant decrease in serum FSH in the Sertraline-treated group compared to the control group (P <0.05). However, this decline appeared to be reversible following termination of exposure to Sertraline. FSH returned to pretreatment levels in the remaining treated rats following 90 days of treatment cessation.
Conclusion: Within the time-frame studied, Sertraline can induce transitory changes in serum FSH of male rats without concomitant spermatogenic changes within the testes. This hormonal change appears to be reversible following withholding of Sertraline. The long-term effect of Sertraline usage on hormonal status and spermatogenesis in rats needs further investigation.
- Sertraline, Spermatogenesis, LH, FSH, Testosterone, infertility
How to Cite
References
2. Hull MG, Glazener CM, Kelly NJ, Conway DI, Foster PA, Hinton RA, Coulson C, Lambert PA, Watt EM, Desai KM. Population study of causes, treatment, and outcome of infertility. Br Med J (Clin Res Ed). 1985 Dec 14;291(6510):1693-7.
3. ElMazoudy R, El-Abd K, Mekkawy D, Kamel K. Developmental effects on hypothalamic, hypophyseal, testicular and steroidogenic patterns of sertraline-exposed male rats by accumulated doses from juvenile to puberty. Ecotoxicology and Environmental Safety. 2020 Jan 30;188:109840.
4. Riggin L, Koren G. Effects of selective serotonin reuptake inhibitors on sperm and male fertility. Canadian Family Physician. 2015 Jun 1;61(6):529-30.
5. Erdemir F, Atilgan D, Firat F, Markoc F, Parlaktas BS, Sogut E. The effect of sertraline, paroxetine, fluoxetine and escitalopram on testicular tissue and oxidative stress parameters in rats. International braz j urol. 2014 Feb;40(1):100-8.
6.Madlool ZS, Faris SA, Hussein AM. Effect of sertraline and fluoxetine on the reproductive abilities of male rats Rattusnorvegicus.University of Thi-Qar Journal of Science. 2019 May 19;7(1):26-32.
7. ELLIS GB, DESJARDINS C. Male rats secrete luteinizing hormone and testosterone episodically. Endocrinology. 1982 May 1;110(5):1618-27.
8. Atli O, Baysal M, Aydogan-Kilic G, Kilic V, Ucarcan S, Karaduman B, Ilgin S. Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms. Asian journal of andrology. 2017 Nov;19(6):672.
9. Jahromy MH, Moghadam AA. Effects of sertraline on sperm motility, number and viability and its relation to blood levels of testosterone, FSH and LH in adult male mice.Advances in Sexual Medicine. 2014 Apr 4;2014.
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