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  3. Vol. 2 No. 3 (2015): Summer
  4. Original / Research Article

Vol. 2 No. 3 (2015)

December 2015

Effect of Zingiber Officinale (Ginger Rhizomes) Hydroethanolic Extract on Hyoscine-Induced Memory Impairment in Adult Male Rats

  • Ali Gomar
  • Abdolkarim Hosseini
  • Naser Mirazi
  • Mojtaba Gomar

International Clinical Neuroscience Journal, Vol. 2 No. 3 (2015), 30 December 2015 , Page 105-110
https://doi.org/10.22037/icnj.v2i3.9829 Published: 2015-12-30

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Abstract

Background: The spice Zingiber officinale or ginger possesses antioxidant activity and
neuroprotective effects. In this study we hypothesized that treatment with hydroethanolic
extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memory
impairment in rats.
Methods: In this experimental study 64 male Wistar rats were divided into eight groups (8 rats
in each group): normal saline, hyoscine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg),
or hyoscine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). Memory impairment was
induced by a single injection of hyoscine (1 mg/kg, i.p). Cognitive functions were evaluated
using passive avoidance learning (PAL) task. Retention test was carried out 24 h after training,
and the latency of entering the dark compartment [step-through latency (STL)] and the total
time in the dark compartment (TDC) were recorded. All statistical analysis was carried out at
5% level of significance using SPSS version 21. The data were analyzed by ANOVA followed
by Tukey’s test.
Results: The time latency in hyoscine-treated group was lower than control (133.87±14.60
vs. 242.12±10.58; p<0.001, respectively). Treatment of the animals by 100 and 200 mg/kg of
ginger extract before the training trial increased the time latency at 24 h after the training trial
(277±4.67 and 280.37±7.68; p<0.01, respectively). Administration of both 100 and 200 mg/kg
doses of the extract in hyoscine received animal groups before retention trials also increased
the time latency than the hyoscine-treated groups (247.37±7.62 and 271.87±9.11; p<0.001,
respectively).
Conclusion: The results revealed that the ginger hydroethanolic extract attenuated hyoscineinduced
memory impairment.

Keywords:
  • Memory
  • Alzheimer
  • Ginger
  • Scopolamine
  • Rat
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How to Cite

1.
Gomar A, Hosseini A, Mirazi N, Gomar M. Effect of Zingiber Officinale (Ginger Rhizomes) Hydroethanolic Extract on Hyoscine-Induced Memory Impairment in Adult Male Rats. Int Clin Neurosci J [Internet]. 2015 Dec. 30 [cited 2025 Jun. 13];2(3):105-10. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/9829
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