International Clinical Neuroscience Journal

Vol. 13 No. Continuous (2026)

Precision NeuroNutrition: Toward Personalized Perioperative Care in Neurosurgery

International Clinical Neuroscience Journal, Vol. 13 No. Continuous (2026), 10 Ordibehesht 2026 , Page 1-6
https://doi.org/10.22037/icnj.v13iContinuous.52881

Abstract

Precision medicine has transformed modern neurosurgery through advances in molecular diagnostics, advanced imaging, artificial intelligence (AI), and individualized therapeutic strategies. In contrast, perioperative nutritional care remains largely based on standardized guidelines that inadequately address the biological heterogeneity of neurosurgical patients. Growing evidence indicates that nutritional status is a modifiable determinant of postoperative outcomes, yet conventional assessment often fails to capture interindividual differences in metabolism, inflammation, body composition, and physiological reserve. This mini-review introduces Precision NeuroNutrition as a conceptual framework for personalized perioperative nutritional care in neurosurgery. It summarizes current evidence on nutritional vulnerability in neurosurgical patients and highlights how body composition analysis, inflammatory and metabolic biomarkers, metabolic phenotyping, microbiome science, multi-omics, and AI may enable biologically informed nutritional assessment and intervention. Precision NeuroNutrition complements, rather than replaces, established evidence-based recommendations such as ESPEN and Enhanced Recovery After Surgery (ERAS) by integrating patient-specific biological, metabolic, and molecular characteristics into nutritional decision-making. Although implementation remains limited by challenges in standardization, validation, cost, and data integration, advances in systems biology and computational medicine offer new opportunities for adaptive nutritional strategies. Precision NeuroNutrition offers a promising roadmap for future research and personalized perioperative nutritional management in modern neurosurgery.

Keywords:
  • Artificial Intelligence; Body Composition; Neurosurgery; Perioperative Nutrition; Precision Medicine; Precision NeuroNutrition; Precision Nutrition

How to Cite

1.
Hajimohammadebrahim-Ketabforoush M, Zali A, Rahmati Roodsari S. Precision NeuroNutrition: Toward Personalized Perioperative Care in Neurosurgery. Int Clin Neurosci J [Internet]. 2026 Sep. 2 [cited 2026 Sep. 5];13(Continuous):1-6. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/52881

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