Mini-Review: Harnessing Swarm Intelligence for Early Alzheimer's Detection
International Clinical Neuroscience Journal,
Vol. 11 No. 1 (2024),
4 November 2025
,
Page e7
https://doi.org/10.22037/icnj.v11i1.47073
Abstract
Alzheimer’s Disease (AD), a leading cause of dementia, affects over 50 million people worldwide and is characterized by progressive cognitive decline, memory impairment, and behavioral changes. Early and accurate diagnosis remains critical for effective intervention, yet traditional methods often face challenges in scalability and precision. In this mini review, we evaluate the emerging role of Swarm Intelligence (SI) in the diagnosis of AD using Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI) modalities. While traditional diagnostic methods suffer from limitations, SI-based algorithms, inspired by the collective behavior of biological swarms, are well-suited to manage complex datasets. Feature selection, parameter tuning, and pattern recognition benefit from techniques such as Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), and Bee Colony Algorithm (BCA). This review highlights SI’s computational efficiency, robustness, and transformative potential in improving diagnostic accuracy and scalability. We also address future challenges and research directions essential for integrating SI into real-world AD diagnostic systems. Ultimately, this work underscores SI’s promise in revolutionizing AD detection and enhancing patient outcomes.
- Alzheimer's disease
- Biological Signal Processing
- Medical Image Processing
- Machine Learning
- Swarm Intelligence
How to Cite
References
Rad EM, Azarnoosh M, Ghoshuni M, Khalilzadeh MM. Diagnosis of mild Alzheimer's disease by EEG and ERP signals using linear and nonlinear classifiers. Biomed Signal Process Control. 2021;70:103049. doi: 10.1016/j.bspc.2021.103049
2. Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024;9(1):211. doi: 10.1038/s41392-024-01858-z
3. Thorgrimsen L, Selwood A, Spector A, et al. Whose quality of life is it anyway? The validity and reliability of the Quality of Life-Alzheimer’s Disease (QoL-AD) scale. Alzheimer Dis Assoc Disord. 2003;17(4):201–208. doi: 10.1097/00002093-200310000-00002
4. Qiu Y, Cheng F. Artificial intelligence for drug discovery and development in Alzheimer’s disease. Curr Opin Struct Biol. 2024;85:102776. doi: 10.1016/j.sbi.2024.102776
5. Dar SA, Imtiaz N. Classification of neuroimaging data in Alzheimer’s disease using particle swarm optimization: A systematic review. Appl Neuropsychol Adult. 2023:1–12. doi: 10.1080/23279095.2023.2234561
6. Manochander T, Prabha S, Anandh K. A systematic literature survey in Alzheimer disease using optimization methods. In: Metaheuristics and Optimization in Computer and Electrical Engineering: Volume 2: Hybrid and Improved Algorithms. 2023:431–443. doi: 10.1007/978-3-031-35045-6_21
7. Almohimeed A, Saad RM, Mostafa S, et al. Explainable artificial intelligence of multi-level stacking ensemble for detection of Alzheimer’s disease based on particle swarm optimization and the sub-scores of cognitive biomarkers. IEEE Access. 2023;11:54321–54333. doi: 10.1109/ACCESS.2023.3278912
8. Rad EM, Azarnoosh M, Ghoshuni M, Khalilzadeh MM. Combining nonlinear features of EEG and MRI to diagnose Alzheimer’s disease. Ann Data Sci. 2024:1–22. doi: 10.1007/s40745-024-00682-9
9. Ravi R, Sridevi T, Devi NN, Mandadi S. Bridging the gap: Integrating machine learning with biomarkers for enhanced Alzheimer’s detection and tracking. In: Deep Generative Models for Integrative Analysis of Alzheimer’s Biomarkers. IGI Global; 2025:1–26. doi: 10.4018/978-1-6684-9912-0.ch001
10. Zeng N, Qiu H, Wang Z, Liu W, Zhang H, Li Y. A new switching-delayed-PSO-based optimized SVM algorithm for diagnosis of Alzheimer’s disease. Neurocomputing. 2018;320:195–202. doi: 10.1016/j.neucom.2018.09.031
11. Kaur S, Singh J. Enhancing medical image analysis and disease surveillance in healthcare: A study on PSO-ACO optimization using swarm intelligence. In: Proc 2nd Int Conf Comput Model Simul Optim (ICCMSO). 2023. doi: 10.1109/ICCMSO57479.2023.10054328
12. Bharanidharan N, Rajaguru H. Performance enhancement of swarm intelligence techniques in dementia classification using dragonfly‐based hybrid algorithms. Int J Imaging Syst Technol. 2020;30(1):57–74. doi: 10.1002/ima.22352
13. Senthilkumar T, Kumarganesh S, Sivakumar P, Periyarselvam K. Primitive detection of Alzheimer’s disease using neuroimaging: A progression model for Alzheimer’s disease—Their applications, benefits, and drawbacks. J Intell Fuzzy Syst. 2022;43(4):4431–4444. doi: 10.3233/JIFS-212519
14. Jo T, Nho K, Risacher SL, Saykin AJ, Alzheimer’s Disease Neuroimaging Initiative. Deep learning detection of informative features in tau PET for Alzheimer’s disease classification. BMC Bioinformatics. 2020;21:405. doi: 10.1186/s12859-020-03731-5
15. Wang R, He Q, Shi L, Che Y, Xu H, Song C. Automatic detection of Alzheimer’s disease from EEG signals using an improved AFS–GA hybrid algorithm. Cogn Neurodyn. 2024;18(2):411–432. doi: 10.1007/s11571-023-09961-4
16. Kaur M, Singh R. Recognition, analysis and classification of Alzheimer ailment using hybrid genetic and particle swarm with deep learning technique. Int J Comput Appl Inf Technol. 2022;13(2):428–438. doi: 10.13140/RG.2.2.26764.97926
17. Saputra R, Agustina C, Puspitasari D, Ramanda R, Pribadi D, Indriani K. Detecting Alzheimer’s disease by the decision tree methods based on particle swarm optimization. In: J Phys Conf Ser. 2020;1539:012012. doi: 10.1088/1742-6596/1539/1/012012
18. Mahmood T, Rehman A, Saba T, Wang Y, Alamri FS. Alzheimer’s disease unveiled: Cutting-edge multi-modal neuroimaging and computational methods for enhanced diagnosis. Biomed Signal Process Control. 2024;97:106721. doi: 10.1016/j.bspc.2024.106721
19. Ganesan P, Ramesh G, Falkowski-Gilski P, Falkowska-Gilska B. Detection of Alzheimer’s disease using Otsu thresholding with tunicate swarm algorithm and deep belief network. Front Physiol. 2024;15:1380459. doi: 10.3389/fphys.2024.1380459
20. Ouchani M, Gharibzadeh S, Jamshidi M, Amini M. A review of methods of diagnosis and complexity analysis of Alzheimer’s disease using EEG signals. Biomed Res Int. 2021;2021:5425569. doi: 10.1155/2021/5425569
21. Perez-Valero E, Morillas C, Lopez-Gordo MA, Carrera-Muñoz I, López-Alcalde S, Vílchez-Carrillo RM. An automated approach for the detection of Alzheimer's disease from resting-state electroencephalography. Front Neuroinform. 2022;16:924547. doi: 10.3389/fninf.2022.924547
22. Albera L, Kachenoura A, Comon P, et al. ICA-based EEG denoising: A comparative analysis of fifteen methods. Bull Pol Acad Sci Tech Sci. 2012;60(3):407–418. doi: 10.2478/v10175-012-0054-3
23. Puri DV, Nalbalwar SL, Nandgaonkar AB, Gawande JP, Wagh A. Automatic detection of Alzheimer’s disease from EEG signals using low-complexity orthogonal wavelet filter banks. Biomed Signal Process Control. 2023;81:104439. doi: 10.1016/j.bspc.2022.104439
24. Kaur G, Gupta M, Kumar R. Swarm intelligence-based feature selection algorithm of EEG classification for brain emotion detection: A review. In: Proc IEEE 8th Int Conf Convergence Technol (I2CT). 2023. doi: 10.1109/I2CT57861.2023.10127319
25. Wang R, Wang H, Shi L, et al. A novel framework of MOPSO-GDM in recognition of Alzheimer's EEG-based functional network. Front Aging Neurosci. 2023;15:1160534. doi: 10.3389/fnagi.2023.1160534
26. Yang S-T, Lee J-D, Chang T-C, et al. Discrimination between Alzheimer’s disease and mild cognitive impairment using SOM and PSO‐SVM. Comput Math Methods Med. 2013;2013:253670. doi: 10.1155/2013/253670
27. Farid AA, Selim G, Khater H. Applying artificial intelligence techniques for prediction of neurodegenerative disorders: A comparative case study on clinical tests and neuroimaging tests with Alzheimer’s disease. Egypt Inform J. 2020;21(4):203–214. doi: 10.1016/j.eij.2020.05.002
28. Rathore S, Habes M, Iftikhar MA, Shacklett A, Davatzikos C. A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer’s disease and its prodromal stages. Neuroimage. 2017;155:530–548. doi: 10.1016/j.neuroimage.2017.03.057
29. Afzal S, Maqsood M, Khan U, et al. Alzheimer disease detection techniques and methods: A review. Multimed Tools Appl. 2021;80(16):24983–25006. doi: 10.1007/s11042-021-10924-3
30. Zhao Z, Chuah JH, Lai KW, et al. Conventional machine learning and deep learning in Alzheimer’s disease diagnosis using neuroimaging: A review. Front Comput Neurosci. 2023;17:1038636. doi: 10.3389/fncom.2023.1038636
31. Kim S-H, Choi T-M, Lee S-K, Kim M, Kim JG, Kim J-H. Event-specific EEG-fNIRS feature fusion for Alzheimer’s disease classification. In: Proc IEEE Int Conf Image Process (ICIP). 2024. doi: 10.1109/ICIP53218.2024.10563849
32. Shankar K, Lakshmanaprabu S, Khanna A, Tanwar S, Rodrigues JJ, Roy NR. Alzheimer detection using group grey wolf optimization-based features with convolutional classifier. Comput Electr Eng. 2019;77:230–243. doi: 10.1016/j.compeleceng.2019.05.003
33. Vasan SS, Jayalakshmi P. Enhancing Alzheimer’s disease detection with chaotic moth flame optimization algorithm: a feature selection approach. In: Proc Int Conf Emerg Technol Comput Sci Interdiscip Appl (ICETCS). 2024. doi: 10.1109/ICETCS59694.2024.10593842
34. Ismail WN, FR PP, Ali MA. A meta-heuristic multi-objective optimization method for Alzheimer’s disease detection based on multi-modal data. Mathematics. 2023;11(4):957. doi: 10.3390/math11040957
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