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  3. Vol. 8 No. 4 (2021): Autumn
  4. Letter to Editor

Vol. 8 No. 4 (2021)

Aban 2021

Fungal Central Nervous System Infections in Patients With COVID-19

  • Mohammad Mahdi Rabiei
  • Alireza Zali
  • Sara Rahmati Roodsari
  • Zahra Arab-Mazar
  • Ensieh Lotfali

International Clinical Neuroscience Journal, Vol. 8 No. 4 (2021), 30 Aban 2021 , Page 154-156
Published: 2021-10-30

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Abstract

Recent studies have indicated that fungal co-infections have a major impact on the morbidity and mortality of patients with COVID-19. In these patients, the excessive production of inflammatory cytokines and the reduction in CD4 + T and CD8 + T cell count entails susceptibility to fungal infections.1 In addition to impaired cell-mediated immunity, comorbidities and immunosuppressive medications have a significant role in the development of fungal infections and have serious impacts on clinical outcomes.1-3

Keywords:
  • CNS
  • Fungal
  • COVID-19
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How to Cite

1.
Rabiei MM, Zali A, Rahmati Roodsari S, Arab-Mazar Z, Lotfali E. Fungal Central Nervous System Infections in Patients With COVID-19. Int Clin Neurosci J [Internet]. 2021 Oct. 30 [cited 2026 Jul. 5];8(4):154-6. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/35309
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References

Tilavberdiev SA, Madaminov FA. Associated fungal infections, related to the global COVID-19 pandemic (literature review). International Journal of Multicultural and Multireligious Understanding. 2021;8(5):619-27.

Rod JE, Oviedo-Trespalacios O, Cortes-Ramirez J. A brief-review of the risk factors for COVID-19 severity. Rev Saude Publica. 2020;54:60. doi: 10.11606/s1518- 8787.2020054002481.

Lotfali E, Ghasemi R, Mardani M, Fattahi A, Rezaei K, Toreyhi H, et al. A review on hematologic malignant patients infected with 2019 novel coronavirus. Arch Clin Infect Dis. 2020;15(3):e107788. doi: 10.5812/ archcid.107788.

Raman Sharma R. Fungal infections of the nervous system: current perspective and controversies in management. Int J Surg. 2010;8(8):591-601. doi: 10.1016/j.ijsu.2010.07.293.

Góralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi. Infection. 2018;46(4):443-59. doi: 10.1007/ s15010-018-1152-2.

McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP, Walsh TJ. Mold infections of the central nervous system. N Engl J Med. 2014;371(2):150-60. doi: 10.1056/ NEJMra1216008.

Silva LN, de Mello TP, de Souza Ramos L, Branquinha MH, Roudbary M, Dos Santos ALS. Fungal infections in COVID-19-positive patients: a lack of optimal treatment options. Curr Top Med Chem. 2020;20(22):1951-7. doi: 10 .2174/156802662022200917110102.

Rabiei MM, Zali A, Rahmati Roodsari S, Arab-Mazar Z, Lotfali E. Candidiasis in COVID-19 patients. Nov Biomed. 2021;9(2):101-3. doi: 10.22037/nbm.v9i2.34133.

Bhatt K, Agolli A, Patel MH, Garimella R, Devi M, Garcia E, et al. High mortality co-infections of COVID-19 patients: mucormycosis and other fungal infections. Discoveries (Craiova). 2021;9(1):e126. doi: 10.15190/d.2021.5.

Sarda R, Swain S, Ray A, Wig N. COVID-19-associated mucormycosis: an epidemic within a pandemic. QJM. 2021. doi: 10.1093/qjmed/hcab165.

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