Executive Function Assessment in Patients With Idiopathic Generalized Epilepsy: Applyingthe Frontal Assessment Battery
International Clinical Neuroscience Journal,
Vol. 8 No. 2 (2021),
27 Farvardin 2021
,
Page 80-84
Abstract
Background: Executive dysfunction is seen in idiopathic generalized epilepsy (IGE). The Frontal Assessment Battery (FAB) is a short neuropsychological instrument designed in clinical settings to evaluate frontal lobe activity. We aimed to assess the clinical use of FAB in patients with IGE for to detect executive impairment.
Method: In this study, 30 patients with IGE and 30 age- and sex-matched healthy controls were included. The presence and severity of executive dysfunction was investigated with FAB. Cognitive flexibility, decision making, working memory, and general intelligence level were examined using Wisconsin Card Sorting Task (WCST), Iowa Gambling Task (IGT), N-back, and Wechsler Adult Intelligence Scale, respectively. In patients with IGE, FAB results were related to their neuropsychological task performance.
Results: The FAB score in patients with IGE was significantly lower compared to healthy participants. In motor programming tasks, patients with IGE performed substantially worse. However, no correlation was found between FAB and neuropsychological task and clinical characteristics.
Conclusion: Executive dysfunction was present in patients with IGE and FAB may be used in these patients as an effective tool for evaluating frontal lobe function.
- Idiopathic generalized epilepsy
- Executive function
- Frontal Assessment Battery
How to Cite
References
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005- 2009. Epilepsia. 2010;51(4):676-85. doi: 10.1111/j.1528- 1167.2010.02522.x.
Jallon P, Latour P. Epidemiology of idiopathic generalized epilepsies. Epilepsia. 2005;46 Suppl 9:10-4. doi: 10.1111/j.1528-1167.2005.00309.x.
Diamond A. Executive functions. Annu Rev Psychol. 2013;64:135-68. doi: 10.1146/annurev-psych-113011-143750.
Simani L, Roozbeh M, Rostami M, Pakdaman H, Ramezani M, Asadollahi M. Attention and inhibitory control deficits in patients with genetic generalized epilepsy and psychogenic nonepileptic seizure. Epilepsy Behav. 2020;102:106672. doi: 10.1016/j.yebeh.2019.106672.
Simani L, Raminfard S, Asadollahi M, Roozbeh M, Ryan F, Rostami M. Neurochemicals of limbic system and thalamofrontal cortical network: are they different between patients with idiopathic generalized epilepsy and psychogenic nonepileptic seizure? Epilepsy Behav. 2020;112:107480. doi: 10.1016/j.yebeh.2020.107480.
Elger CE, Helmstaedter C, Kurthen M. Chronic epilepsy and cognition. Lancet Neurol. 2004;3(11):663-72. doi: 10.1016/ s1474-4422(04)00906-8.
Hommet C, Sauerwein HC, De Toffol B, Lassonde M. Idiopathic epileptic syndromes and cognition. Neurosci Biobehav Rev. 2006;30(1):85-96. doi: 10.1016/j.neubiorev.2005.06.004.
Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology. 2000;55(11):1621- 6. doi: 10.1212/wnl.55.11.1621.
Moorhouse P, Gorman M, Rockwood K. Comparison of EXIT-25 and the Frontal Assessment Battery for evaluation of executive dysfunction in patients attending a memory clinic. Dement Geriatr Cogn Disord. 2009;27(5):424-8. doi: 10.1159/000212755.
Slachevsky A, Villalpando JM, Sarazin M, Hahn-Barma V, Pillon B, Dubois B. Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease. Arch Neurol. 2004;61(7):1104-7. doi: 10.1001/ archneur.61.7.1104.
Rodrigues GR, Souza CP, Cetlin RS, de Oliveira DS, Pena- Pereira M, Ujikawa LT, et al. Use of the frontal assessment battery in evaluating executive dysfunction in patients with Huntington’s disease. J Neurol. 2009;256(11):1809-15. doi: 10.1007/s00415-009-5197-0.
Lima CF, Meireles LP, Fonseca R, Castro SL, Garrett C. The Frontal Assessment Battery (FAB) in Parkinson’s disease and correlations with formal measures of executive functioning. J Neurol. 2008;255(11):1756-61. doi: 10.1007/s00415-008- 0024-6.
Nagata T, Shinagawa S, Ochiai Y, Aoki R, Kasahara H, Nukariya K, et al. Association between executive dysfunction and hippocampal volume in Alzheimer’s disease. Int Psychogeriatr. 2011;23(5):764-71. doi: 10.1017/s1041610210002164.
Agah E, Asgari-Rad N, Ahmadi M, Tafakhori A, Aghamollaii V. Evaluating executive function in patients with temporal lobe epilepsy using the Frontal Assessment Battery. Epilepsy Res. 2017;133:22-7. doi: 10.1016/j.eplepsyres.2017.03.011.
Sanjari Moghaddam H, Doost Hoseini M, Khaleghi MR, Tafakhori A, Dolatshahi M, Pourmirbabaei S, et al. Evaluating executive functions in patients with juvenile myoclonic epilepsy using Frontal Assessment Battery. Behav Neurol. 2020;2020:8710373. doi: 10.1155/2020/8710373.
Guedj E, Allali G, Goetz C, Le Ber I, Volteau M, Lacomblez L, et al. Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: a SPECT study in frontotemporal dementia. J Neurol Sci. 2008;273(1-2):84-7. doi: 10.1016/j. jns.2008.06.035.
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512-21. doi: 10.1111/ epi.13709.
Asaadi S, Ashrafi F, Omidbeigi M, Nasiri Z, Pakdaman H, Amini-Harandi A. Persian version of frontal assessment battery: correlations with formal measures of executive functioning and providing normative data for Persian population. Iran J Neurol. 2016;15(1):16-22.
Loughman A, Bowden SC, D’Souza W. Cognitive functioning in idiopathic generalised epilepsies: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2014;43:20-34. doi: 10.1016/j.neubiorev.2014.02.012.
Chowdhury FA, Elwes RD, Koutroumanidis M, Morris RG, Nashef L, Richardson MP. Impaired cognitive function in idiopathic generalized epilepsy and unaffected family members: an epilepsy endophenotype. Epilepsia. 2014;55(6):835-40. doi: 10.1111/epi.12604.
Rai VK, Shukla G, Afsar M, Poornima S, Pandey RM, Rai N, et al. Memory, executive function and language function are similarly impaired in both temporal and extra temporal refractory epilepsy-a prospective study. Epilepsy Res. 2015;109:72-80. doi: 10.1016/j.eplepsyres.2014.09.031.
de Lima AB, Moreira F, da Mota Gomes M, Maia-Filho H. Clinical and neuropsychological assessment of executive function in a sample of children and adolescents with idiopathic epilepsy. Arq Neuropsiquiatr. 2014;72(12):954-9. doi: 10.1590/0004-282x20140191.
Riccio CA, Pliego JA, Cohen MJ, Park Y. Executive function performance for children with epilepsy localized to the frontal or temporal lobes. Appl Neuropsychol Child. 2015;4(4):277- 84. doi: 10.1080/21622965.2014.923774.
Nyhus E, Barceló F. The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update. Brain Cogn. 2009;71(3):437-51. doi: 10.1016/j.bandc.2009.03.005.
Lie CH, Specht K, Marshall JC, Fink GR. Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. Neuroimage. 2006;30(3):1038-49. doi: 10.1016/j.neuroimage.2005.10.031.
Seo J, Chang Y, Jang KE, Park JW, Kim YT, Park SJ, et al. Altered executive function in the welders: a functional magnetic resonance imaging study. Neurotoxicol Teratol. 2016;56:26- 34. doi: 10.1016/j.ntt.2016.05.003.
Birn RM, Kenworthy L, Case L, Caravella R, Jones TB, Bandettini PA, et al. Neural systems supporting lexical search guided by letter and semantic category cues: a self-paced overt response fMRI study of verbal fluency. Neuroimage. 2010;49(1):1099- 107. doi: 10.1016/j.neuroimage.2009.07.036.
Wandschneider B, Thompson PJ, Vollmar C, Koepp MJ. Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data. Epilepsia. 2012;53(12):2091-8. doi: 10.1111/ epi.12003.
Devinsky O, Gershengorn J, Brown E, Perrine K, Vazquez B, Luciano D. Frontal functions in juvenile myoclonic epilepsy. Neuropsychiatry Neuropsychol Behav Neurol. 1997;10(4):243-6.
Kim JH, Suh SI, Park SY, Seo WK, Koh I, Koh SB, et al. Microstructural white matter abnormality and frontal cognitive dysfunctions in juvenile myoclonic epilepsy. Epilepsia. 2012;53(8):1371-8. doi: 10.1111/j.1528-1167.2012.03544.x.
Gupta S, Kwan P, Faught E, Tsong W, Forsythe A, Ryvlin P. Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: an analysis from the National Health and Wellness Survey. Epilepsy Behav. 2016;55:146-56. doi: 10.1016/j.yebeh.2015.12.018.
Jiang Y, Wu J, Wang Y, Zhou N, Wang K. Impaired executive function by interictal epileptiform discharges in patients with idiopathic generalized epilepsy. Epilepsy J. 2017;3(1):118. doi: 10.4172/2472-0895.1000118.
Mefford HC, Muhle H, Ostertag P, von Spiczak S, Buysse K, Baker C, et al. Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. PLoS Genet. 2010;6(5):e1000962. doi: 10.1371/journal.pgen.1000962.
Meador KJ. Brain function and anatomy in juvenile myoclonic epilepsy. Epilepsy Curr. 2010;10(1):13-4. doi: 10.1111/j.1535- 7511.2009.01340.x.
Pulsipher DT, Seidenberg M, Guidotti L, Tuchscherer VN, Morton J, Sheth RD, et al. Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy. Epilepsia. 2009;50(5):1210-9. doi: 10.1111/j.1528- 1167.2008.01952.x.
Høie B, Sommerfelt K, Waaler PE, Alsaker FD, Skeidsvoll H, Mykletun A. Psychosocial problems and seizure-related factors in children with epilepsy. Dev Med Child Neurol. 2006;48(3):213-9. doi: 10.1017/s0012162206000454.
Taylor J, Kolamunnage-Dona R, Marson AG, Smith PE, Aldenkamp AP, Baker GA. Patients with epilepsy: cognitively compromised before the start of antiepileptic drug treatment? Epilepsia. 2010;51(1):48-56. doi: 10.1111/j.1528- 1167.2009.02195.x.
Witt JA, Elger CE, Helmstaedter C. Adverse cognitive effects of antiepileptic pharmacotherapy: each additional drug matters. Eur Neuropsychopharmacol. 2015;25(11):1954-9. doi: 10.1016/j.euroneuro.2015.07.027.
Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011;4(6):385- 407. doi: 10.1177/1756285611417920.
Woermann FG, Free SL, Koepp MJ, Sisodiya SM, Duncan JS. Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI. Brain. 1999;122(Pt 11):2101-8. doi: 10.1093/brain/122.11.2101.
Vollmar C, O’Muircheartaigh J, Symms MR, Barker GJ, Thompson P, Kumari V, et al. Altered microstructural connectivity in juvenile myoclonic epilepsy: the missing link. Neurology. 2012;78(20):1555-9. doi: 10.1212/ WNL.0b013e3182563b44.
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