International Clinical Neuroscience Journal

Vol. 8 No. 2 (2021)

Schizophrenia: The Dark Side of Toxoplasmosis

International Clinical Neuroscience Journal, Vol. 8 No. 2 (2021), 27 March 2021 , Page 53-54

Abstract

Toxoplasma gondii is an intracellular parasite that has been associated with several mental disorders. It usually causes an inapparent primary infection. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals.1-3
Schizophrenia is a neurological disorder characterized with long-term and devastating neuropsychological problems, usually presenting in adolescents or young adults. The disease affects almost 1.1% of the global population including all races and ethnic groups with an equal prevalence in both sexes.1 T. gondii seroprevalence is strongly associated with 12-month generalized anxiety disorder but not with other anxiety, depressive, or alcohol-related disorders. Because of the intracellular nature of some parasites, their treatment and development of new drugs is a major challenge for scientists.4 Recently, the use of nanoparticles and nano-scaffolds has suggested for the treatment of parasitic diseases, although limited research has been done in this regard.5-7

Keywords:
  • Toxoplasma gondii
  • Toxoplasmosis
  • Schizophrenia
  • CNS

How to Cite

1.
Eftekharian S, Rahmati Roodsari S, Arab-Mazar Z, Rahimi M. Schizophrenia: The Dark Side of Toxoplasmosis. Int Clin Neurosci J [Internet]. 2021 Mar. 27 [cited 2023 Dec. 9];8(2):53-4. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/33637

References

Saraei-Sahnesaraei M, Shamloo F, Jahani Hashemi H, Khabbaz F, Alizadeh SA. Relation between Toxoplasma gondii infections and schizophrenia. Iran J Psychiatry Clin Psychol. 2009;15(1):3-9. [Persian].

Rahimi M, Mohseni M, Bostan H, Parsipour S, Darabi E, Mohammadzadeh T. The prevalence of intestinal parasites in the patients referred to the laboratories of Baqiyatallah hospital during 2010-2014. J Ardabil Univ Med Sci. 2016;15(4):414- 22. [Persian].

Bitaraf HR, Arab-Mazar Z, Ghanimatdan M, Mohammadi M, Mohseni M, Parsipour S, et al. Seroprevalence of Toxoplasma gondii in military personnel and their families referred to the military hospital in Tehran, Iran. Novelty in Biomedicine. 2017;5(4):152-7. doi: 10.22037/nbm.v5i4.16896.

Suvisaari J, Torniainen-Holm M, Lindgren M, Härkänen T, Yolken RH. Toxoplasma gondii infection and common mental disorders in the Finnish general population. J Affect Disord. 2017;223:20-5. doi: 10.1016/j.jad.2017.07.020.

Taghipour N, Deravi N, Rahimi M. Chitosan-based scaffolds, suitable structures for wound healing dressing: a short review. Regen Reconstr Restor. 2020;5:e11. doi: 10.22037/rrr. v5i1.31130.

Rahimi M, Seyyed Tabaei SJ, Ziai SA, Sadri M. Anti-leishmanial effects of chitosan-polyethylene oxide nanofibers containing berberine: an applied model for Leishmania wound dressing. Iran J Med Sci. 2020;45(4):286-97. doi: 10.30476/ ijms.2019.45784.

Seyyed Tabaei SJ, Rahimi M, Akbaribazm M, Ziai SA, Sadri M, Shahrokhi SR, et al. Chitosan-based nano-scaffolds as antileishmanial wound dressing in BALB/c mice treatment: characterization and design of tissue regeneration. Iran J Basic Med Sci. 2020;23(6):788-99. doi: 10.22038/ ijbms.2020.41361.9770.

Rahimi M, Arab-Mazar Z, Roodsari SR. Nanomedicine: The Novel Weapon against Parasitic Infections. Novelty in Biomedicine.;8(4):210-211. doi: 10.22037/nbm.v8i4.30416.

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