Etiology of the Neonatal Seizures: An Epidemiological Study
International Clinical Neuroscience Journal,
Vol. 6 No. 4 (2019),
23 September 2019
,
Page 129-132
Abstract
Background: Neonatal seizure is a rare neurologic condition. The current study aimed at determining the etiology of neonatal seizure.
Methods: The current study evaluated the data of 100 neonates who were hospitalized at neonatal intensive care unit (NICU) during 2015-2017. A pediatric neurologist made the final diagnosis of seizure. Patients’ medical records were used to review neonatal seizure variables. SPSS (version 16) was used to perform the statistical analyses.
Results: The current study enrolled 100 newborns (41% female) admitted to the NICU following the first episode of seizure and the body temperature of 36.8-39.2°C (mean: 37.2°C). Of 100 participants, 94 (94%) had acute symptomatic seizure and 6 (6%) were compatible with neonatal epilepsy syndrome criteria. According to the results, the commonest etiologies were the neonatal encephalopathy and hypoxic-ischemic encephalopathy constituting 82% of participants.
Conclusion: The consequences of acute symptomatic seizures in neonates are determined mainly by the etiology of the seizures. Seizure burden and use of anti-seizure drugs may also have some impact, but this has yet to be fully defined.
- Newborns
- Seizure
- Neonatal Encephalopathy
How to Cite
References
Agarwal M, Fox SM. 2013. Pediatric seizures. Emergency medicine clinics of North America 31:733-54
Patterson JL, Carapetian SA, Hageman JR, Kelley KR. 2013. Febrile seizures. Pediatric annals 42:249-54
Mizrahi EM WKSns. In: Epileptic syndromes in infancy,
childhood and adolescence, 3rd, Roger J, Bureau M, Dravet CH, et al. (Eds), John Libbey, 2002.
p.15.
Friedman MJ, Sharieff GQ. 2006. Seizures in children. Pediatric clinics of North America 53:257-77
Mizrahi EMJAoE. 2010. Neonatal seizures.491-502
Co JPT, Elia M, Engel Jr J, Guerrini R, Mizrahi EM, et al. 2007. Proposal of an algorithm for diagnosis and treatment of neonatal seizures in developing countries. 48:1158-64
Glass HCJCip. 2014. Neonatal seizures: advances in mechanisms and management. 41:177-90
Leung AK, Robson WLM. 2007. Febrile seizures. Journal of Pediatric Health Care 21:250-5
Rothman SM, Glass HC, Chang T, Sullivan JE, Bonifacio SL, Shellhaas RAJN. 2014. Risk factors for EEG seizures in neonates treated with hypothermia: A multicenter cohort studyAuthor Response. 83:1773-4
Nelson KB, Leviton AJAjodoc. 1991. How much of neonatal encephalopathy is due to birth asphyxia? 145:1325-31
Gaffney G, Flavell V, Johnson A, Squier M, Sellers SJAoDiC-F, Edition N. 1994. Cerebral palsy and neonatal encephalopathy. 70:F195-F200
Leviton A, Nelson KBJPn. 1992. Problems with definitions and classifications of newborn encephalopathy. 8:85-90
Adhikari S, Sathian B, Koirala DP, Rao KS. 2013. Profile of children admitted with seizures in a tertiary care hospital of Western Nepal. BMC pediatrics 13:43
Kirton A, deVeber GJS. 2013. Life after perinatal stroke. 44:3265-71
Verboon-Maciolek MA, Truttmann AC, Groenendaal F, Skranes J, Døllner H, et al. 2012. Development of cystic periventricular leukomalacia in newborn infants after rotavirus infection. 160:165-8. e1
Daly LP, Osterhoudt KC, Weinzimer SA. 2003. Presenting features of idiopathic ketotic hypoglycemia. The Journal of emergency medicine 25:39-43
Freedman BD, Hughan K, Garibaldi L. 2010. Hypoglycemic seizure. Clinical pediatrics 49:1078-80
Hoe FM. 2008. Hypoglycemia in infants and children. Advances in pediatrics 55:367-84
Chen CY, Chang YJ, Wu HP. 2010. New-onset seizures in pediatric emergency. Pediatrics and neonatology 51:103-11
Velíšková J, DeSantis KA. 2013. Sex and Hormonal influences on Seizures and Epilepsy. Hormones and behavior 63:267-77
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