A Case of Guillain-Barre Syndrome with Significant Lymphocytic Pleocytosis
International Clinical Neuroscience Journal,
Vol. 4 No. 2 (2017),
12 June 2017
,
Page 77-78
https://doi.org/10.22037/icnj.v4i2.16187
Abstract
Guillain-Barre syndrome (GBS) is an immune-mediated polyneuropathy. In the cerebrospinal fluid (CSF) characteristic increased protein without pleocytosis i.e., albuminocytologic dissociation is seen. But cases of GBS with significant CSF lymphocytosis have rarely been reported. Here, we present a 38-year-old man with dysarthria, dysphagia, bilateral facial palsy, and limb weakness with the diagnosis of GBS. Nerve Conduction Study confirmed the diagnosis but interestingly in the CSF study increased protein and lymphocytic predominant pleocytosis were found. Other possible differential diagnoses were ruled out by appropriate paraclinical studies. The patient underwent treatment with intravenous immunoglobulin and showed favorable response.
- Guillain-Barre syndrome
- lymphocytosis
- cerebrospinal fluid
How to Cite
References
Brettschneider J, Petzold A, Süssmuth S, Tumani H. Cerebrospinal fluid biomarkers in Guillain-Barrésyndrome-where do we stand? J Neurol. 2009 Jan; 256(1):3-12.
Gupta D, Nair M, Baheti NN, Sarma PS, Kuruvilla A. Electrodiagnostic and clinical aspects of Guillain-Barré syndrome: an analysis of 142 cases. J Clin Neuromuscul Dis. 2008 Dec; 10(2):42-51.
Uncini A, Yuki N. Electrophysiologic and immunopathologic correlates in Guillain-Barré syndrome subtypes. Expert Rev Neurother. 2009 Jun; 9(6):869-84.
Uncini A, Kuwabara S. Electrodiagnostic criteria for Guillain-Barrè syndrome: a critical revision and the need for an update. Clin Neurophysiol. 2012 Aug; 123(8):1487-95.
Akbayram S, Doğan M, Akgün C, Peker E, Sayιn R, Aktar F, and et al. Clinicalfeatures and prognosis with Guillain-Barré syndrome. Ann Indian Acad Neurol. 2011 Apr; 14(2):98-102.
Asbury AK. New concepts of Guillain-Barré syndrome. J Child Neurol. 2000 Mar; 15(3):183-91.
Rauschka H, Jellinger K, Lassmann H, Braier F, Schmidbauer M. Guillain-Barré syndrome with marked pleocytosis or a significant proportion of polymorphonuclear granulocytes in the cerebrospinal fluid: neuropathological investigation of five cases and review of differential diagnoses. Eur J Neurol. 2003 Sep; 10(5):479-86.
- Abstract Viewed: 470 times
- PDF Downloaded: 1203 times