International Clinical Neuroscience Journal

Vol. 3 No. 4 (2016)

CLIPPERS: Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive To Steroids

International Clinical Neuroscience Journal, Vol. 3 No. 4 (2016), 7 February 2017 , Page 219-223
https://doi.org/10.22037/icnj.v3i4.15717

Abstract

A novel type of brainstem-predominant encephalomyelitis was first described as chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in 2010 by Pittocket al and then few additional patients were reported. Here we report a 50-year-old Iranian male who presented with a number of clinical features described as typical for CLIPPERS. The association of typical clinical presentation and typical MR imaging could be sufficient for a reliable diagnosis of CLIPPERS.

Keywords:
  • Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive To Steroids
  • CLIPPERS
  • Brainstem
  • Corticosteroid
  • Perivascular Infiltration

How to Cite

1.
Assarzadegan F, Hesami O, Safarpour Lima B, Zoghi A, Sakhaee E. CLIPPERS: Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive To Steroids. Int Clin Neurosci J [Internet]. 2017 Feb. 7 [cited 2026 Jul. 25];3(4):219-23. Available from: https://journals.sbmu.ac.ir/neuroscience/article/view/15717

References

Pittock SJ, Debruyne J, Krecke KN, Giannini C, van den Ameele J, De Herdt V, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 2010;133:2626-2634.

Simon NG, Parratt JD, Barnett MH, Buckland ME, Gupta R, Hayes MW, et al. Expanding the clinical, radiological and neuropathological phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). J Neurol Neurosurg Psychiatry. 2012;83(1):15–22.

Taieb G, Duflos C, Renard D, Audoin B, Kaphan E, Pelletier J, et al. Long-term outcomes of CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) in a consecutive series of 12 patients. Arch Neurol. 2012;69:847-855.

Buttmann M, Metz I, Brecht I, Brück W, Warmuth-Metz M. Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids(CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report. J Neurol Sci. 2013;324:183-186.

Kastrup O, van de Nes J, Gasser T, Keyvani K. Three cases of CLIPPERS: a serial clinical, laboratory and MRI follow-up study. J Neurol. 2011;258:2140-2146.

Sempere AP, Mola S, Martin-Medina P, Bernabeu A, Khabbaz E, Lopez-Celada S. Response to Immunotherapy in CLIPPERS: Clinical, MRI, and MRS Follow-Up. J Neuroimaging. 2011;23:254-255.

Wang L, Holthaus EA, Jimenez XF, Tavee J, Li Y. MRI evolution of CLIPPERS syndrome following herpes zoster infection. J Neurol Sci. 2015;348:277-278.

Taieb G, Uro-Coste E, Clanet M, Lassmann H, Benouaich-Amiel A, Laurent C. A central nervous system B-cell lymphoma arising two years after initial diagnosis of CLIPPERS. J Neurol Sci. 2014;344:224-226.

Duprez TP, Sindic CJ. Contrast-enhanced magnetic resonance imaging and perfusion-weighted imaging for monitoring features in severe CLIPPERS. Brain. 2011;134(8):184.

Dudesek A, Rimmele F, Tesar S, Kolbaske S, Rommer PS, Benecke R, et al. CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 2014;175(3):385–396.

Jerca O, Manouchehrinia A, Tanasescu R. A new defined entity among the spectrum of central nervous system inflammation: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Rom J Neurol Psychiatry. 2011;X (2):77–81.

Ferreira RM, Machado G, Souza AS, Lin K, Corrêa-Neto Y. CLIPPERS-like MRI findings in a patient with multiple sclerosis. J Neurol Sci. 2013;327:61–62.

Hillesheim PB, Parker JR, Parker JC Jr, Escott E, Berger JR. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids following influenza vaccination. Arch Pathol Lab Med. 2012;136:681–685.

Biotti D, Deschamps R, Shotar E et al. CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Pract Neurol. 2011;11:349–351.

Wijntjes J, Wouda EJ, Siegert CE, Karas GB, Vlaar AM. Need for prolonged immunosupressive therapy in CLIPPERS – a case report. BMC Neurol. 2013;13:49.

Pesaresi I, Sabato M, Desideri I, Puglioli M, Moretti P, Cosottini M. MR investigation of CLIPPERS: role of susceptibility weighted and perfusion weighted imaging. Magn Reson Imaging. 2013;31:1640–1642.

Christopher Lane, Robin Howard, Rahul Phadke. Guy’s and St. Thomas, NHS Trust; National Hospital, Queen Square. AN EXTENDED CLIPPERS PHENOTYPE. J Neurol Neurosurg Psychiatry. 2014;85(10):4.

Kerrn-Jespersen BM, Lindelof M, Illes Z, Blaabjerg M, Lund EL, Klausen C, et al. CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. J Neurol Sci. 2014 Aug 15;343(1-2):224-7.

  • Abstract Viewed: 458 times
  • PDF Downloaded: 527 times

Download Statastics