Association between Cognitive function and metabolic syndrome using Montreal Cognitive Assessment Test.
International Clinical Neuroscience Journal,
Vol. 2 No. 3 (2015),
30 December 2015
Background and Purpose: The increased risk for cognitive defects in individuals affected by
metabolic syndrome especially in those patients with cardiovascular disorders is now claimed.
We aimed to assess the relationship between cognitive performance and the various components
of metabolic syndrome.
Methods: One hundred and eighteen consecutive individuals aged 30 to 86 years were included
into this cross-sectional survey. The metabolic syndrome and its definitive components were
defined according to the definition described in the Framingham Heart Study by NCEP ATP III
criteria. The Montreal Cognitive Assessment (MOCA) questionnaire was employed to cognitive
Results: Those patients with metabolic syndrome had significantly lower mean MOCA score
compare to the group without metabolic syndrome (19.11 ± 5.49 versus 21.28 ± 4.56, p =
0.021). Among all cognition sub domains, the mean attention score was significantly lower in
the group with metabolic syndrome than in another group. In a multivariate linear regression
model adjusting sex and age variables showed that the presence of metabolic syndrome could
effectively predict cognitive impairment (beta = -2.202, SE = -0.214, p = 0.013).
Conclusion: The presence of metabolic syndrome can be mainly related to damaging cognition
especially impairing the power of attention.
- Cognitive function
- Metabolic syndrome
How to Cite
Nikmat AW, Al-Mashoor SH, Hashim NA. Quality of life
in people with cognitive impairment: nursing homes versus
home care. Int Psychogeriatr. 2014 Dec 11:1-10.
McCade D, Savage G, Guastella A, Hickie IB, Lewis
SJ, Naismith SL. Emotion recognition in mild cognitive
impairment: relationship to psychosocial disability and
caregiver burden. J Geriatr Psychiatry Neurol. 2013
Scult M, Haime V, Jacquart J, Takahashi J, Moscowitz B,
Webster A, et al. A Healthy Aging Program for Older Adults:
Effects on Self-efficacy and Morale.Adv Mind Body Med.
Glisky EL. Changes in Cognitive Function in Human Aging.
In: Riddle DR, editor. Brain Aging: Models, Methods, and
Mechanisms. Boca Raton (FL): CRC Press; 2007.
Woods B1, Aguirre E, Spector AE, Orrell M. Cognitive
stimulation to improve cognitive functioning in people
with dementia.Cochrane Database Syst Rev. 2012 Feb
Verhaeghen P, Cerella J. Aging, executive control, and
attention: a review of meta-analyses. NeurosciBehav
Shen L1, Thompson PM, Potkin SG, Bertram L, Farrer
LA, Foroud TM, et al. Alzheimer’s Disease Neuroimaging
Initiative. Genetic analysis of quantitative phenotypes in
AD and MCI: imaging, cognition and biomarkers. Brain
Imaging Behav. 2014 Jun;8(2):183-207.
PelicanoPaulos J1, Massano J. Clinical, genetic and
neuropathological features of frontotemporal dementia:
an update and guide. Acta Med Port. 2013 Jul-
Aug;26(4):392-401. Epub 2013 Aug 30.
Jiang T1, Yu JT, Tian Y, Tan L. Epidemiology and etiology
of Alzheimer’s disease: from genetic to non-genetic factors.
Curr Alzheimer Res. 2013 Oct;10(8):852-67.
Beydoun MA1, Beydoun HA, Kitner-Triolo MH, Kaufman
JS, Evans MK, Zonderman AB. Thyroid hormones are
associated with cognitive function: moderation by sex,
race, and depressive symptoms. J ClinEndocrinolMetab.
Osterweil D1, Syndulko K, Cohen SN, Pettler-Jennings
PD, Hershman JM, Cummings JL, et al. Cognitive function
in non-demented older adults with hypothyroidism.J Am
Geriatr Soc. 1992 Apr;40(4):325-35.
Dorn LD1, Cerrone P. Cognitive function in patients with
Cushing syndrome: a longitudinal perspective. ClinNurs
Res. 2000 Nov;9(4):420-40.
Qiu C1, Sigurdsson S, Zhang Q, Jonsdottir MK,
Kjartansson O, Eiriksdottir G, et al. Diabetes, markers of
brain pathology and cognitive function: the Age, Gene/
Environment Susceptibility-Reykjavik Study. Ann Neurol.
Goldstein FC1, Ashley AV, Endeshaw YW, Hanfelt J, Lah JJ,
Levey AI. Effects of hypertension and hypercholesterolemia
on cognitive functioning in patients with alzheimer disease.
Alzheimer Dis AssocDisord. 2008 Oct-Dec;22(4):336-42.
Zambón D1, Quintana M, Mata P, Alonso R, Benavent J,
Cruz-Sánchez F, et al. Higher incidence of mild cognitive
impairment in familial hypercholesterolemia. Am J Med.
Peeters CF, Dziura J, van Wesel F. Pathophysiological
domains underlying the metabolic syndrome: an
alternative factor analytic strategy. Ann Epidemiol. 2014
Lusis AJ1, Attie AD, Reue K. Metabolic syndrome: from
epidemiology to systems biology. Nat Rev Genet. 2008
Baxter AJ1, Coyne T, McClintock C. Dietary patterns and
metabolic syndrome--a review of epidemiologic evidence.
Asia Pac J ClinNutr. 2006;15(2):134-42.
Azimi-Nezhad M1, Herbeth B, Siest G, Dadé S, Ndiaye NC,
Esmaily H, et al. High prevalence of metabolic syndrome in
Iran in comparison with France: what are the components that
explain this? MetabSyndrRelatDisord. 2012 Jun;10(3):181-8.
doi: 10.1089/met.2011.0097. Epub 2012 Jan 27.
Delavar MA1, Lye MS, Khor GL, Hanachi P, Hassan ST.
Prevalence of metabolic syndrome among middle aged
women in Babol, Iran. Southeast Asian J Trop Med Public
Health. 2009 May;40(3):612-28.
Khan RJ1, Gebreab SY1, Riestra P1, Xu R1, Davis SK1.
Parent offspring association of metabolic syndrome in the
Framingham Heart Study.DiabetolMetabSyndr. 2014 Dec
Yaffe K1, Weston AL, Blackwell T, Krueger KA. The
metabolic syndrome and development of cognitive
impairment among older women.Arch Neurol. 2009
Chang T1, Lung F, Yen Y. Depressive symptoms, cognitive
impairment, and metabolic syndrome in community-dwelling
elderly in Southern Taiwan. Psychogeriatrics. 2014 Dec 17.
Bachyns’kaNIu, Kopchak OO. Special features of mild
cognitive impairment in patients with metabolic syndrome.
LikSprava. 2014 Mar-Apr;(3-4):37-44.
Collins B, Harley A, Wroolie T. C-13A Systematic Review of
the Effects of Metabolic Syndrome on Cognition in Relation
to Gender.Arch ClinNeuropsychol. 2014 Sep;29(6):577.
Parnowski T, Kałuza B. Metabolic syndrome and cognitive
dysfunction in the old age.Psychiatr Pol. 2013 Nov-
Oh HM1, Kim SH, Kang SG, Park SJ, Song SW. The
Relationship between Metabolic Syndrome and Cognitive
Function.Korean J Fam Med. 2011 Sep;32(6):358-66. doi:
Panza F1, Frisardi V, Capurso C, Imbimbo BP, Vendemiale
G, Santamato A, et al. Metabolic syndrome and cognitive
impairment: current epidemiology and possible underlying
mechanisms. J Alzheimers Dis. 2010;21(3):691-724.
Taylor VH1, MacQueen GM. Cognitive dysfunction
associated with metabolic syndrome. Obes Rev. 2007
Yates KF1, Sweat V, Yau PL, Turchiano MM, Convit A.
Impact of metabolic syndrome on cognition and brain: a
selected review of the literature. ArteriosclerThrombVasc
Biol. 2012 Sep;32(9):2060-7.
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