Effects of Neodymium-Doped Yttrium Aluminium Garnet (Nd:YAG) Laser Irradiation on Bone Metabolism During Tooth Movement
Journal of Lasers in Medical Sciences,
Vol. 7 No. 1 (2016),
26 January 2016
,
Page 40-44
Abstract
Introduction: The aim of this study is to evaluate the effects of low-level neodymium-doped yttrium aluminium garnet (Nd:YAG) laser irradiation on orthodontic tooth movement and histological examination.
Methods: Eleven male Wistar rats (aged 10 weeks) were included. To produce experimental tooth movement in rats, 10 g force was applied to maxillary first molars with nickel titanium closed coil springs. Right molars were irradiated with Nd:YAG laser on days 0, 1, 2, 3, 7, 10, 14, 17, 21 and 24, while un-irradiated left molars were used as control. Distance between mesial side of second molar and distal side of first molar was measured on μCT image during tooth movement and the rats were sacrificed 4 weeks after the initiation of tooth movement.
Results: The amount of tooth movement was significantly greater in the irradiation group (0.20 ± 0.06) than in the control group (0.14 ± 0.03) during the first week (P < 0.05). However, no statistically significant difference was found afterwards. There was a tendency of higher tartrate-resistant acid phosphatase (TRAP)-positive nuclei count in the pressure zones of the laser irradiation group, but it was not statistically significant. In immuno-histological examination, expressions of alkaline phosphatase (ALP) and receptor activator of nuclear factor kappa-B ligand (RANKL) were higher at the pressure site of the laser irradiation group than the control group, whereas there was no difference in osteoprotegerin (OPG) expression.
Conclusion: The results suggest that low-level Nd:YAG laser may stimulate osteoclast and osteoblast activation and accelerate bone metabolism during tooth movement.
- Nd
- YAG laser
- Movement
- Tooth
- LLLT
- RANKL
How to Cite
References
Köle H. Surgical operations on the alveolar ridge to correct occlusal abnormalities. Oral Surg Oral Med Oral Pathol. 1959;12(5):515-529. doi:10.1016/0030-4220(59)90153-7.
Tuncay OC, Killiany DM. The effect of gingival fiberotomy on the rate of tooth movement. Am J Orthod. 1986; 89(3):212-215. doi:10.1016/0002-9416(86)90034-5.
Young L, Binderman I, Yaffe A, Beni L, Vardimon AD. Fiberotomy enhances orthodontic tooth movement and diminishes relapse in a rat model. Orthod Craniofac Res. 2013;16(3):161-168. doi:10.1111/ocr.12014.
Kanzaki H, Chiba M, Shimizu Y, Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res. 2002;17(2):210-220. doi:10.1359/jbmr.2002.17.2.210.
Chen Q. Effect of pulsed electromagnetic field on orthodontic tooth movement through transmission electromicroscopy. Zhonghua Kou Qiang Yi Xue Za Zhi. 1991; 26(1):7-10.
Nishimura M, Chiba M, Ohashi T, et al. Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. Am J Orthod Dentofacial Orthop. 2008; 133(4):572-583. doi:10.1016/j.ajodo.2006.01.046.
Sousa MV, Scanavini MA, Sannomiya EK, Velasco LG, Angelieri F. Influence of low-level laser on the speed of orthodontic movement. Photomed Laser Surg. 2011;29(3):191-196. doi:10.1089/pho.2009.2652
Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013;28(1):41-47. doi:10.1007/s10103-012-1059-6.
Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012;141(3):289-297. doi:10.1016/j. ajodo.2011.09.009.
Ninomiya T, Miyamoto Y, Ito T, Yamashita A, Wakita M, Nishisaka T. High-intensity pulsed laser irradiation accelerates bone formation in metaphyseal trabecular bone in rat femur. J Bone Miner Metab. 2003;21(2):67-73. doi:10.1007/s007740300011.
Mohkovska T, Mayberry J. It is time to test low level laser therapy in Great Britain. Postgrad Med J. 2005;81(957):436- 441. doi:10.1136/pgmj.2004.027755.
Sun G, Tuner J. Low-level laser therapy in dentistry. Dent Clin N Am. 2004;48(4):1061-1076. doi:10.1016/j. cden.2004.05.004.
Kawasaki K, Shimizu N. Effects of low-energy laser irradiation on bone remodeling during experimental tooth movement in rats. Lasers Surg Med. 2000;26:282-291.
Wei ZT, Du CS, Zhao YF, Wu DQ. Measurement of the area of periodontal membrance. Chin J Stomatol. 1964;10, 9–12.
Begg PR. Differential force in orthodontic treatment. Am J Orthod. 1956;42:481-510.
Gonzales C, Hotokezaka H, Yoshimatsu M, Yozgatian JH, Darendeliler MA, Yoshida N. Force magnitude and duration effects on amount of tooth movement and root resorption in the rat molar. Angle Orthod. 2008;78:502- 509. doi:10.2319/052007-240.1
Hamblin MR, Waynant RW, Anders J. Mechanisms for low-light therapy I. Proc SPIE 6140. 2006;614001.
Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B. 1999;49:1-17. doi:10.1016/s1011-1344(98)00219-x.
Karu T. Ten Lectures on Basic Science of Laser Phototherapy. Grngesberg, Sweden: Prima Books AB; 2007.
Goulart CS, Nouer PR, Mouramartins L, Garbin IU, de Fátima Zanirato Lizarelli R. Photoradiation and orthodontic movement: experimental study with canines. Photomed Laser Surg. 2006;24(2):192-196. doi:10.1089/ pho.2006.24.192.
Limpanichkul W, Godfrey K, Srisuk N, Rattanayatikul C. Effects of low-level laser therapy on the rate of orthodontic tooth movement. Orthod Craniofac Res. 2006;9:38-43. doi:10.1111/j.1601-6343.2006.00338.x.
Altan BA, Sokucu O, Ozkut MM, Inan S. Metrical and histological investigation of the effects of low-level laser therapy on orthodontic tooth movement. Lasers Med Sci. 2012;27(1):131-140. doi:10.1007/s10103-010-0853-2.
Fujita S, Yamaguchi Y, Utsunomiya T, Yamamoto H, Kasai K. Low-energy laser irradiation stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res. 2008;11:143-155.
Ogasawara T, Yoshimine Y, Kiyoshima T, , et al. In situ expression of RANKL, RANK, Osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue. J Periodontal Res. 2004; 39:42-49.
Yamaguchi M, Fujita S, Yoshida T, Okikawa K, Utsunomiya T, Yamamoto H. Low-energy laser irradiation stimulates the tooth movement velocity via expression of M-CSF and c-fms. Orthod Waves. 2007;66:139-148. doi:10.1016/j. odw.2007.09.002.
- Abstract Viewed: 895 times
- PDF Downloaded: 623 times