Effects of Photobiomodulation With Two Wavelengths of 630 and 810 nm on Diabetic Neuropathy Photobiomodulation and diabetic neuropathy
Journal of Lasers in Medical Sciences,
Vol. 14 (2023),
29 January 2023
,
Page e22
Abstract
Introduction: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes patients. Among different therapeutic approaches for treating DPN, low-level laser therapy (LLLT) or photobiomodulation (PBM) is a new promising non-invasive technique. This study aims to evaluate the effect of visible and infrared LLLT on DPN.
Methods: Sixty DPN patients enrolled in a randomized-controlled study. The patients were randomly divided into the same population of control and laser groups. The patients in the laser group received LLLT with two wavelengths of 630 and 819 nm and conventional therapy, and those in the control group received conventional therapy alone. Irradiation of the patients lasted 15 minutes per session, and it was performed over the surface of each foot three times a week for 12 sessions. The patients were evaluated at baseline and at the end of the study with the Michigan Neuropathy Screening Instrument (MNSI) and microfilament test.
Results: Patients’ sensation in the right foot in the monofilament test had increased from 22 (84.6%) to 26 (86.7%) (P=0.000), and in the left foot it had increased from 20 (80%) to 25 (86.2%) (P=0.001). The mean and standard deviation of the scores of section A of the Michigan questionnaire showed a statistically significant difference between the two groups (P<0.05), but the B part scores of the Michigan test did not show a significant difference.
Conclusion: This study showed that the visible and infra-red LLLT significantly improved the symptoms of diabetic neuropathy without any side effects.
- Diabetic neuropathy
- Low-Level Laser Therapy
- LLLT
- Photobiomodulation
How to Cite
References
Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson DJ, et al. Diabetic peripheral neuropathy: epidemiology, diagnosis,and pharmacotherapy. Clin Ther. 2018;40(6):828-49. doi:10.1016/j.clinthera.2018.04.001.
Parasoglou P, Rao S, Slade JM. Declining skeletal muscle function in diabetic peripheral neuropathy. Clin Ther. 2017; 39(6):1085-103. doi:10.1016/j.clinthera.017.05.001.
Stadelmann WK, Digenis AG, Tobin GR. Impediments to wound healing. Am J Surg. 1998;176(2A Suppl):39S-47S. doi:10.1016/s0002-9610(98)00184-6.
Alleman CJ, Westerhout KY, Hensen M, Chambers C, Stoker M, Long S, et al. Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: a review of the literature. Diabetes Res Clin Pract. 2015;109(2):215-25. doi:10.1016/j.diabres.2015.04.031.
Davies M, Brophy S, Williams R, Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care. 2006;29(7):1518-22. doi:10.2337/dc05-2228.
Campos L, Cruz É P, Pereira FS, Arana-Chavez VE, Simões A. Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters. J Biophotonics. 2016;9(11-12):1236-45. doi:10.1002/jbio.201600014.
Hamblin MR. Mechanisms and applications of the antiinflammatory effects of photobiomodulation. AIMS Biophys. 2017;4(3):337-61. doi: 10.3934/biophy.2017.3.337.
Yamany AA, Sayed HM. Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy. J Adv Res. 2012;3(1):21-8. doi:10.1016/j.jare.2011.02.009.
Bashiri H. Evaluation of low-level laser therapy in reducing diabetic polyneuropathy-related pain and sensorimotor disorders. Acta Med Iran. 2013;51(8):543-7.
Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, et al. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009;40(4):1359-
doi: 10.1161/strokeaha.109.547547. 11. Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, et al. Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer’s susceptibility gene. J Alzheimers Dis. 2010;22(1):307-13. doi: 10.3233/jad-2010-100129.
Zein R, Selting W, Hamblin MR. Review of light parameters and photobiomodulation efficacy: dive into complexity. J Biomed Opt. 2018;23(12):1-17. doi: 10.1117/1.jbo.23.12.120901.
Shashi Kumar CG, Maiya AG, Hande HM, Vidyasagar S, Rao K, Rajagopal KV. Efficacy of low level laser therapy on painful diabetic peripheral neuropathy. Laser Ther. 2015;24(3):195- 200. doi: 10.5978/islsm.15-OR-12.
Herman WH, Pop-Busui R, Braffett BH, Martin CL, Cleary PA, Albers JW, et al. Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: results from the
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications. Diabet Med. 2012;29(7):937-44. doi:10.1111/j.1464-5491.2012.03644.x.
Shanb AA, Youssef EF, Al Baker WI, Al-Khamis FA, Hassan A, Jatoi NA. The efficacy of adding electromagnetic therapy or laser therapy to medications in patients with diabetic peripheral neuropathy. J Lasers Med Sci. 2020;11(1):20-8. doi:10.15171/jlms.2020.05.
da Silva Leal MV, Lima MO, Costa DR, Nicolau RA, Ribeiro LA, Costa DR, et al. Evaluation of the effects of photobiomodulation (808 nm) on pain and quality of life of diabetic neuropathy patients. Res Soc Dev. 2022;11(2):e26211225552. doi:10.33448/rsd-v11i2.25552.
Peric Z, Cvetkovic B. Electrophysiological evaluation of low-intensity laser therapy in patients with diabetic polyneuropathy. Facta Univ Med Biol. 2006;13(1):11-4.
Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V. Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care. 2004;27(4):921-4. doi: 10.2337/diacare.27.4.921.
Rojas JC, Gonzalez-Lima F. Low-level light therapy of the eye and brain. Eye Brain. 2011;3:49-67. doi: 10.2147/eb.s21391.
Khamseh ME, Kazemikho N, Aghili R, Forough B, Lajevardi M, Hashem Dabaghian F, et al. Diabetic distal symmetric polyneuropathy: effect of low-intensity laser therapy. Lasers Med Sci. 2011;26(6):831-5. doi: 10.1007/s10103-011-0977-z.
Swislocki A, Orth M, Bales M, Weisshaupt J, West C, Edrington J, et al. A randomized clinical trial of the effectiveness of photon stimulation on pain, sensation, and quality of life in patients with diabetic peripheral neuropathy. J Pain Symptom Manage. 2010;39(1):88-99. doi 10.1016/j. jpainsymman.2009.05.021.
Uozumi Y, Nawashiro H, Sato S, Kawauchi S, Shima K, Kikuchi M. Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation. Lasers Surg Med. 2010;42(6):566-76. doi: 10.1002/lsm.20938.
Ashrafi F, Rezaei A, Azhideh A, Tabeie F, Gachkar L, Arab Ahmadi M, et al. Effectiveness of extremely low frequency electromagnetic field and pulsed low level laser therapy in acute stroke treatment. Int Clin Neurosci J. 2020;7(3):127-31.
- Abstract Viewed: 460 times
- PDF Downloaded: 482 times