Assessment of Immunological Effects of Low-Level Er: YAG Laser Radiation
Journal of Lasers in Medical Sciences,
Vol. 13 (2022),
10 January 2022
,
Page e25
Abstract
Introduction: Low-level laser radiation have a significant effect on cell proliferation. Various investigations about effect of Er: YAG laser on the treated cell lines are published. Determining of core targeted proteins is an attractive subject. Aim of this research is identifying the critical targeted protein by low-level Er: YAG laser in Primary Osteoblast-like Cells.
Methods: Data was extracted from literature about proteomic assessment of 3.3 J/cm2 of low-level Er: YAG laser radiation on osteoblast-like cells of rat calvaria. The significant differentially expressed proteins (DEPs) plus 100 first neighbors were analyzed via network analysis and gene ontology enrichment.
Results: Numbers of 9 DEPs among the 12 queried proteins were included in the main connected component. Analysis revealed that Cxcl1 is a key targeted protein in response to laser radiation. Presence of Cxcl1 in the significant cellular pathways indicates that cell growth and proliferation are affected.
Conclusion: It can be concluded that Immune system is affected by laser to activate cellular defend against stress.
- Laser, Proteomics, Cxcl1, Protein, Cell proliferation
How to Cite
References
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