Evaluating the Efficacy of the Er,Cr:YSGG Fractional Laser Before Treatment With Triamcinolone NN Ointment in Oral Lichen Planus Lesions Lichen Planus and Laser Assisted Drug Delivery System
Journal of Lasers in Medical Sciences,
Vol. 13 (2022),
10 January 2022
,
Page e23
Abstract
Introduction: It has been demonstrated that laser technology can enhance topical drug absorption. This study aimed to determine the effects of Er, Cr: YSGG laser radiation before the application of topical corticosteroids in the healing of oral lichen planus.
Methods: In this double-blind split-mouth clinical trial, 32 lesions were chosen from eight patients affected by oral lichen planus (OLP). The oral lesions were randomly categorized into two groups. The first group had topical treatment with triamcinolone NN ointment and the second group had laser radiation (Er,Cr:YSGG) for eight weeks before starting the ointment. For each lesion, the irritating level based on the VAS score, the lesion level based on the Thongprasom scale score, and the healing time were measured, and the collected data were analyzed by the Friedman test and the Wilcoxon’s statistical test.
Results: The mean healing time based on the verbal analog scale (VAS) score was not significantly different between the two treatment groups (P>0.05). The mean healing time based on Thongprasom scale scores did not show any significant difference between the two treatment groups (P>0.05).
Conclusion: The application of the Er,Cr:YSGG laser before treatment with triamcinolone NN ointment did not show any advantage for the average healing time compared to a medicine regimen with only triamcinolone NN ointment.
Doi:10.34172/jlms.2022.23.
- Oral lichen planus; Corticosteroid; Laser; Er,Cr:YSGG
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References
Mollaoglu N. Oral lichen planus: a review. Br J Oral Maxillofac Surg. 2000;38(4):370-7. doi: 10.1054/bjom.2000.0335.
Pakfetrat A, Javadzadeh-Bolouri A, Basir-Shabestari S, Falaki F. Oral Lichen Planus: a retrospective study of 420 Iranian patients. Med Oral Patol Oral Cir Bucal. 2009;14(7):E315-8
Glick M, Greenberg MS, Lockhart PB, Challacombe SJ. Burket's oral medicin. 13th ed. Hoboken: Wiley-Blackwell, 2021: 89-95.
Bianco L, Romano F, Maggiora M, Bongiovanni L, Guzzi N, Curmei E, et al. Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trialInt J Dent Hyg. 2019;17(2):161-169. doi: 10.1111/idh.12377.
Vente C, Reich K, Rupprecht R. Erosive mucosal lichen planus: response to topical treatment with Tacrolimus. Br J Dermatol. 1999;140(2):338-42. doi: 10.1046/j.1365-2133.1999.02672.x.
Lo Muzio L, della Valle A, Mignogna MD, Pannone G, Bucci P, Bucci E, Sciubba J. The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. J Oral Pathol Med. 2001;30(10):611-7. doi: 10.1034/j.1600-0714.2001.301006.x.
Buajeeb W, Kraivaphan P, Pobrurksa C. Efficacy of topical retinoic acid compared with topicalfluocinoloneacetonide in the treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83(1):21-5. doi: 10.1016/s1079-2104(97)90085-8.
Plemons JM, Rees TD, Zachariah NY. Absorption of a topical steroid and evaluation of adrenal suppression in patients with erosive lichen planus. Oral Surg Oral Med Oral Pathol 1990; 69(6):688-93. doi: 10.1016/0030-4220(90)90349-w.
Voute AB, Schulten EA, Langendijk PN. Fluocinonide in an adhesive base for treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol 1993; 75(2):181-5. doi: 10.1016/0030-4220(93)90091-h.
Lozada-Nur F, Miranda C, Maliksi R. Double-blind clinical trial of 0.05% clobetasol propionate (corrected from proprionate) ointment in orabase and 0.05% Fluocinonide Ointment in Orabase in the treatment of patients with oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol 1994;77(6):598-604. doi: 10.1016/0030-4220(94)90318-2.
Parent D. Les ulcérations de la bouche [Oral ulcerations]. Rev Med Brux. 2011;32(4):210-8. French..
Braun SA, Schrumpf H, Buhren BA, Homey B, Gerber PA. Laser-assisted drug delivery: mode of action and use in daily clinical practice. J Dtsch Dermatol Ges. 2016;14(5):.480-8. doi: 10.1111/ddg.12963.
Hsiao CY, Yang SC, Alalaiwe A, Fang JY. Laser ablation and topical drug delivery: a review of recent advances. Expert Opin Drug Deliv 2019;16(9):.937-52. doi: 10.1080/17425247.2019.1649655.
Ali FR, Al-Niaimi F. Laser-assisted drug delivery in dermatology: from animal models to clinical practice. Lasers Med Sci. 2016;31(2):373-81. doi: 10.1007/s10103-015-1853-z.
Goo BL. Laser Assisted Drug and Cosmeceutical Delivery System of the Skin. Med Laser. 2015;4(2):9-51.
Hendel KK, Bagger C, Olesen UH, Janfelt C, Hansen SH, Haedersdal M, et al. Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging. Drug Deliv. 2019;26(1):51-244. doi: 10.1080/10717544.2019.1574937.
Badawi AM, Osman MA. Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma. Clin Cosmet Investig Dermatol. 2018;11:13-20. doi: 10.2147/CCID.S147413.
Sobhi RM, Sharaoui I, El Nabarawy EA, Esmail RS, Hegazy RA, Aref DH. Comparative study of fractional CO 2 laser and fractional CO 2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis. Lasers Med Sci. 2018;33(4):909-916. doi: 10.1007/s10103-018-2457-1.
Derikvand N, Ghasemi SS, Moharami M, Shafiei E, Chiniforush N. Management of oral lichen planus by 980 nm diode laser. J Lasers Med Sci. 2017;8(3):150-154. doi: 10.15171/jlms.2017.27
Sahebjamee M, Rohani B, Momen Beitollahi J, Mansourian A, Khalili M, Baghaee F, et al. Assessment of compatibility of clinical diagnosis with histopathological diagnosis of oral lichen planus. Razi Journal of Medical Sciences. 2013;20(107):46-51
Khalighi HR, Mojahedi M, Parandoosh A. Efficacy of Er, Cr: YSGG laser–assisted delivery of topical anesthesia in the oral mucosa. Clin Oral Investig. 2021;25(3):1055-1058. doi: 10.1007/s00784-020-03399-x.
Park JH, Chun JY, Lee JH. Laser-assisted topical corticosteroid delivery for the treatment of keloids. Lasers Med Sci. 2017;32(3):601-608. doi: 10.1007/s10103-017-2154-5.
Kraeva E, Ho D, Jagdeo J. Successful Treatment of Keloid With Fractionated Carbon Dioxide (CO2) Laser and Laser-Assisted Drug Delivery of Triamcinolone Acetonide Ointment in an African-American Man. J Drugs Dermatol. 2017;16(9):925-927.
Cavalié M, Sillard L, Montaudié H, Bahadoran P, Lacour JP, Passeron T. Treatment of keloids with laser‐assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther. 2015;28(2):74-8. doi: 10.1111/dth.12187.
Martin MS, Collawn SS. Combination treatment of CO2 fractional laser, pulsed dye laser, and triamcinolone acetonide injection for refractory keloid scars on the upper back. J Cosmet Laser Ther. 2013;15(3):166-70. doi: 10.3109/14764172.2013.780448.
Yun PL, Tachihara R, Anderson RR. Efficacy of erbium: yttrium-aluminum-garnet laser-assisted delivery of topical anesthetic. J Am Acad Dermatol. 2002;47(4):542-7. doi: 10.1067/mjd.2002.124819.
Kumar V, Abbas AK, Aster JC, Perkins JA. Robbins basic pathology. 10th ed. Philadelphia: Elsevier Pennsylvania, 2018.
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