Phototherapy With LED as an Effective Treatment for Chemotherapy-Induced Oral Mucositis in Hamsters
Journal of Lasers in Medical Sciences,
Vol. 11 No. 4 (2020),
3 Mehr 2020
,
Page 475-480
Abstract
Introduction: Oral mucositis (OM) has been considered one of the most feared collateral effects of oncological treatments. Some therapies have been used, such as light-emitting diode (LED), with promising results, but with no sufficient evidence in the literature.
Objective: Our study aimed to evaluate, by clinical and histological analysis, the effect of LED on the treatment of chemotherapy-induced OM (CIOM) in an animal model.
Methods: Twenty male hamsters were equally distributed to two groups: control (C), which received anesthesia and CIOM induction; and LED (L), which received anesthesia, CIOM induction, and LED treatment (635 nm, 120 mW, 0.48 J). The clinical analysis was performed through two specific scales for OM analysis on days 5, 7 and 10 of the experiment. In addition, the injured area of all hamsters check pouch mucosa was removed and processed for histological analysis on the last experimental day.
Results: After statistical analysis, group L showed less severity of OM when compared with the C group (P < 0.05); beyond that, both healed completely on day 10.
Conclusion: Our results suggested that the phototherapy with LED had a positive effect on accelerating repair, reducing the severity of CIOM.
- chemotherapy
- oral mucositis
- phototherapy
- LED
- 5-Fluorouracil
How to Cite
References
Bjordal JM, Bensadoun RJ, Tunèr J, Frigo L, Gjerde K, Lopes-Martins RA. A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis. Support Care Cancer. 2011;19(8):1069-77. doi: 10.1007/s00520-011-1202-0.
Scully C, Epstein J, Sonis S. Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. Head Neck. 2003;25(12):1057-70. doi: 10.1002/hed.10318.
Murphy CK, Fey EG, Watkins BA, Wong V, Rothstein D, Sonis ST. Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters. Clin Cancer Res. 2008;14(13):4292-7. doi: 10.1158/1078-0432.CCR-07-4669.
Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453-61. doi: 10.1002/cncr.28592.
Campos L, Simões A, Sá PH, Eduardo Cde P. Improvement in quality of life of an oncological patient by laser phototherapy. Photomed Laser Surg. 2009;27(2):371-4. doi: 10.1089/pho.2008.2300.
Campos L, Cruz ÉP, Pereira FS, Arana-Chavez VE, Simões A. Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters. J Biophotonics. 2016;9(11-12):1236-45. doi: 10.1002/jbio.201600014.
Cotomacio CC, Campos L, Nesadal de Souza D, Arana-Chavez VE, Simões A. Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters. J Biomed Opt. 2017;22(1):18003. doi: 10.1117/1.JBO.22.1.018003.
Freitas AC, Campos L, Brandão TB, Cristófaro M, Eduardo Fde P, Luiz AC, et al. Chemotherapy-induced oral mucositis: effect of LED and laser phototherapy treatment protocols. Photomed Laser Surg. 2014;32(2):81-7. doi: 10.1089/pho.2013.3576.
Simões A, Eduardo FP, Luiz AC, Campos L, Sá PH, Cristófaro M, et al. Laser phototherapy as topical prophylaxis against head and neck cancer radiotherapy-induced oral mucositis: comparison between low and high/low power lasers. Lasers Surg Med. 2009;41(4):264-70. doi: 10.1002/lsm.20758.
Anschau F, Webster J, Capra MEZ, de Azeredo da Silva ALF, Stein AT. Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis. Lasers Med Sci. 2019;34(6):1053-62. doi: 10.1007/s10103-019-02722-7.
Antunes HS, Schluckebier LF, Herchenhorn D, Small IA, Araújo CMM, Viégas CMP, et al. Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients receiving concurrent chemoradiation. Oral Oncol. 2016;52:85-90. doi: 10.1016/j.oraloncology.2015.10.022.
Bensadoun RJ, Nair RG. Low-level laser therapy in the management of mucositis and dermatitis induced by cancer therapy. Photomed Laser Surg. 2015;33(10):487-91. doi: 10.1089/pho.2015.4022.
França CM, França CM, Núñez SC, Prates RA, Noborikawa E, Faria MR, et al. Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters. J Photochem Photobiol B. 2009;94(1):25-31. doi: 10.1016/j.jphotobiol.2008.09.006.
Marín-Conde F, Castellanos-Cosano L, Pachón-Ibañez J, Serrera-Figallo MA, Gutiérrez-Pérez JL, Torres-Lagares D. Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial. Int J Oral Maxillofac Surg. 2019;48(7):917-23. doi: 10.1016/j.ijom.2018.12.006.
Sacono NT, Costa CAS, Bagnato VS, Abreu-e-Lima FCB. Light-emitting diode therapy in chemotherapy-induced mucositis. Lasers Surg Med. 2008;40(9):625-33. doi: 10.1002/lsm.20677.
Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR, et al. Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Support Care Cancer. 2016;24(6):2793-805. doi: 10.1007/s00520-016-3153-y.
Freitas AC, Campos L, Brandão TB, Cristófaro M, Eduardo Fde P, Luiz AC, et al. Chemotherapy-induced oral mucositis: effect of LED and laser phototherapy treatment protocols. Photomed Laser Surg. 2014;32(2):81-7. doi: 10.1089/pho.2013.3576.
Lang-Bicudo L, Eduardo Fde P, Eduardo Cde P, Zezell DM. LED phototherapy to prevent mucositis: a case report. Photomed Laser Surg. 2008;26(6):609-13. doi: 10.1089/pho.2007.2228.
Adamskaya N, Dungel P, Mittermayr R, Hartinger J, Feichtinger G, Wassermann K, et al. Light therapy by blue LED improves wound healing in an excision model in rats. Injury. 2011;42(9):917-21. doi: 10.1016/j.injury.2010.03.023.
Chaves ME, Araújo AR, Piancastelli AC, Pinotti M. Effects of low-power light therapy on wound healing: LASER x LED. An Bras Dermatol. 2014;89(4):616-23. doi: 10.1590/abd1806-4841.20142519.
Corazza AV, Jorge J, Kurachi C, Bagnato VS. Photobiomodulation on the angiogenesis of skin wounds in rats using different light sources. Photomed Laser Surg. 2007;25(2):102-6. doi: 10.1089/pho.2006.2011.
Whelan HT, Connelly JF, Hodgson BD, Barbeau L, Post AC, Bullard G, et al. NASA light-emitting diodes for the prevention of oral mucositis in pediatric bone marrow transplant patients. J Clin Laser Med Surg. 2002;20(6):319-24. doi: 10.1089/104454702320901107.
Sonis ST, Tracey C, Shklar G, Jenson J, Florine D. An animal model for mucositis induced by cancer chemotherapy. Oral Surg Oral Med Oral Pathol. 1990;69(4):437-43. doi: 10.1016/0030-4220(90)90376-4.
Wilder-Smith P, Hammer-Wilson MJ, Zhang J, Wang Q, Osann K, Chen Z, et al. In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography. Clin Cancer Res. 2007;13(8):2449-54. doi: 10.1158/1078-0432.CCR-06-2234.
Cruz Éde P, Campos L, Pereira Fda S, Magliano GC, Benites BM, Arana-Chavez VE, et al. Clinical, biochemical and histological study of the effect of antimicrobial photodynamic therapy on oral mucositis induced by 5-fluorouracil in hamsters. Photodiagnosis Photodyn Ther. 2015;12(2):298-309. doi: 10.1016/j.pdpdt.2014.12.007.
Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh ASJ, Hamilton J, et al. Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp Biol Med (Maywood). 2009;234(4):430-41. doi: 10.3181/0810-RM-301.
Xavier M, David DR, de Souza RA, Arrieiro AN, Miranda H, Santana ET, et al. Anti-inflammatory effects of low-level light emitting diode therapy on Achilles tendinitis in rats. Lasers Surg Med. 2010;42(6):553-8. doi: 10.1002/lsm.20896.
Tenis CA, Martins MD, Gonçalves MLL, Silva DFT, Cunha Filho JJD, Martins MAT, et al. Efficacy of diode-emitting diode (LED) photobiomodulation in pain management, facial edema, trismus, and quality of life after extraction of retained lower third molars: A randomized, double-blind, placebo-controlled clinical trial. Medicine (Baltimore). 2018;97(37):e12264. doi: 10.1097/MD.0000000000012264.
Corti L, Chiarion-Sileni V, Aversa S, Ponzoni A, D'Arcais R, Pagnutti S, et al. Treatment of chemotherapy-induced oral mucositis with light-emitting diode. Photomed Laser Surg. 2006;24(2):207-13. doi: 10.1089/pho.2006.24.207.
Freire Mdo R, Freitas R, Colombo F, Valença A, Marques AM, Sarmento VA. LED and laser photobiomodulation in the prevention and treatment of oral mucositis: experimental study in hamsters. Clin Oral Investig. 2014;18(3):1005-13. doi: 10.1007/s00784-013-1058-4.
Lalla RV, Ashbury FD. The MASCC/ISOO mucositis guidelines: dissemination and clinical impact. Support Care Cancer. 2013;21(11):3161-3. doi: 10.1007/s00520-013-1924-2.
Bezinelli LM, Eduardo FP, Neves VD, Correa L, Lopes RM, Michel-Crosato E, et al. Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study. Eur J Cancer Care (Engl). 2016;25(4):668-74. doi: 10.1111/ecc.12344.
- Abstract Viewed: 327 times
- PDF Downloaded: 201 times