Laser Treatment of Darier Disease: Report of Two Cases and Systematic Review of the Literature
Journal of Lasers in Medical Sciences,
Vol. 11 No. 4 (2020),
3 October 2020
,
Page 395-404
Abstract
Introduction: Darier Disease (DD) is a chronic disease with high morbidity and limited treatment options. Laser efficacy in the treatment of DD remains understudied.
Methods: A literature search conducted between 07/21/2017 and 05/05/2018 identified all original cases of DD treated with laser therapy.
Results: Outcomes from 24 patients were reviewed, 22 patients were identified in the literature and 2 cases are included from our institution. Five types of lasers were identified [CO2 laser, Er:YAG laser, pulse dye laser [PDL], diode laser, erbium-doped fiber laser], with CO2 (46%) and PDL (42%) being the most common. Seventy-nine percent of patients were treated with more than one procedure (average, 3 procedures). The estimated body surface treated with each session ranged from 5%-50%. The most common adverse events came from CO2 and Er: YAG lasers and included dyspigmentation, pain, and post-laser erythema and edema. The time to response (mode, 1 month) was only reported in half of the studies.
Conclusion: Laser treatments appear to be a promising alternative to standardized therapies in DD.
- Laser; Treatment; Darier disease; Keratosis follicularis
How to Cite
References
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