Treatment of basal cell cancer with a pulsed copper vapor laser: A Case Series

Svetlana V. Klyuchareva; Igor V. Ponomarev; Sergey B. Topchiy; Alexandra E. Pushkareva; Yury N. Andrusenko

Treatment of basal cell cancer with a pulsed copper vapor laser: A Case Series

Journal of Lasers in Medical Sciences, Vol. 10 No. 4 (2019), , Page 350-354
Published 1 October 2019

Abstract

Introduction: Basal cell carcinoma (BCC) is the most prevalent form of non-melanoma skin cancer commonly arising in elderly patients. Currently, many laser systems are applied for the treatment of BCC. However, up to the present, there have been several reports concerning ocular side effects due to the laser procedure in the borders of the periorbital area. This determines the feasibility of testing new laser surgical modes for the management of periorbital BCC. This stuay aimed to estimate both the efficacy, the early post-radiated side effects and long-term outcomes of the CVL treatment of periorbital BCC.

Methods: Two men and 6 women aged 50 to 77 years were diagnosed with periorbital BCC according to the data of both the clinical evaluation and histological examination of the tissue samples taken from the involved area. Six months after the laser treatment, the histological examination of skin samples from the borderline of the irradiated area was made again. All patients were followed for 24 months after the laser treatment of BCC. The laser treatment was administered during one session of copper vapor laser (CVL) (Yakhroma-Med model). The treatment included CVL radiation with a wavelength of 511 nm and 578 nm, in the ratio of 3:2. The power level was set up to 3 W, and the exposure time was equal from 200 to 600 ms. The pulse duration accounted for 15 ns. The diameter of the light spot on the skin surface amounted to 1 mm.

Results: Dual-wavelengths CVL treatment of periorbital BCC provided a complete elimination of malignant cells and dysplastic vessels during one procedure. The duration of skin healing amounted to 2-4 weeks. There were neither ocular injuries or pronounced skin side effects nor relapses within 24 months after the laser procedure.

Conclusion: CVL treatment of periorbital BCC provides relevant cosmetic results without ocular injuries and relapses.

Keywords:

Periorbital BCC
Copper vapor laser
Ocular injury
Selective vascular heating

How to Cite

Klyuchareva, S. V., Ponomarev, I. V., Topchiy, S. B., Pushkareva, A. E., & Andrusenko, Y. N. (2019). Treatment of basal cell cancer with a pulsed copper vapor laser: A Case Series. Journal of Lasers in Medical Sciences, 10(4), 350-354. Retrieved from https://journals.sbmu.ac.ir/jlms/article/view/23444

References

Hollis DE, Scheibner A. Ultrastructural changes in epidermal Langerhans cells and melanocytes in response to ultraviolet irradiation, in Australians of Aboriginal and Celtic descent. Br J Dermatol. 1988;119(1) :21-31. doi: 10.1111/j.1365-2133.1988.tb07097.x

Schuch AP, Moreno NC, Schuch NJ, Menck CF, Garcia CC. Sunlight damage to cellular DNA: Focus on oxidatively generated lesions. Free Radic Biol Med. 2017;107:110-124. doi: 10.1016/j.freeradbiomed.2017.01.029

Wu CS, Chen GS, Lin PY, Pan IH, Wang ST, Lin SH, et al. Tazarotene induces apoptosis in human basal cell carcinoma via activation of caspase-8/t-Bid and the reactive oxygen species-dependent mitochondrial pathway. DNA cell biol. 2014;33(10): 652-666. doi: 10.1089/dna.2014.2366

Purohit NK, Robu M, Shah RG, Geacintov NE, Shah GM. Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro. Sci Rep. 2016;6:19020. doi: 10.1038/srep19020.

Kim M, Lee J, Park TJ, Kang HY.Paracrine crosstalk between endothelial cells and melanocytes through clusterin to inhibit pigmentation. Exp Dermatol. 2018;27(1):98-100. doi: 10.1111/exd.13443

Quan T, Xu Y, Qin Z, Robichaud P, Betcher S, Calderone K, et al. Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation. Am J Pathol. 2014;184(4): 937-943. doi: 10.1016/j.ajpath.2013.12.017

Bakshi A, Chaudhary SC, Rana M, Elmets CA, Athar M. Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol Carcinog. 2017; 56(12):2543-2557. doi: 10.1002/mc.22690.

Pelosini L, Smith HB, Schofield JB, Meeckings A, Dithal A, Khandwala M. A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates. Eye. 2015;29(8):1092. doi:10.1038/eye.2015.97

Shahshahani MM, Ehsani A, Noormohammadpour P, Gholamali F. 595nm Pulsed dye laser: an alternative to treat basal cell carcinomas. J Lasers Med Sci. 2011;2(3):98-102. doi:10.22037/2010.v2i3.2353.

Parver DL, Dreher RJ, Kohanim S, Zimmerman P, Garrett G, Devisetty L, et al. Ocular injury after laser hair reduction treatment to the eyebrow. Arch Ophthalmol. 2012;130(10): 1330-1334. doi: 10.1001/archophthalmol.2012.1988.

Rigel DS, Robinson JK, Ross MI, Friedman R, Cockerell CJ, Lim H, Stockfleth E, Kirkwood JM, editors. Cancer of the Skin: Expert Consult. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2011.

Minars N, Blyumin-Karasik M. Treatment of basal cell carcinomas with pulsed dye laser: a case series. J skin cancer. 2012;2012:286480. doi: 10.1155/2012/286480.

Hibler BP, Sierra H, Cordova M, Phillips W, Rajadhyaksha M, Nehal KS, et al. Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof‐of‐principle pilot study. Br J Dermatol. 2016;174(6):1359-1364. doi: 10.1111/bjd.14414

Eimpunth S, Oganesyan G, Hamman Sh, Lee RA, Jiang IB, Kim SS. Effectiveness of a 595-nm pulsed dye laser for the treatment of basal cell carcinoma using stacked-pulse session. J Am Acad Dermatol. 2014 May;70(5):ab134.

Derjabo AD, Cema I, Lihacova I, Derjabo LEDLL, Sroka R, editors. 980nm laser for difficult-to-treat basal cell carcinoma. Medical Laser Applications and Laser-Tissue Interactions VI; 2013; Munich: Optical Society of America.

Ortiz AE, Anderson RR, DiGiorgio C, Jiang SI, Shafiq F, Avram MM.An expanded study of long‐pulsed 1064 nm Nd: YAG laser treatment of basal cell carcinoma. Lasers surg med. 2018;50(7):727-731. doi: 10.1002/lsm.22803.

Moskalik КK, Kozlow A, Demin E, Boiko E. Powerful neodymium laser radiation for the treatment of facial carcinoma: 5 year follow-up data. Eur J Dermatol. 2010; 20(6):738–742.

Gunes A, Yasar C, Tok L, Tok O. Two cases of anterior uveitis after laser eyebrow epilation. Cornea. 2015, 34(1): 101-102. doi: 10.1097/ICO.0000000000000294

Huang A, Phillips A, Adar T, Hui A. Ocular injury in cosmetic laser treatments of the face. J Clin Aesthet Dermatol. 2018;11(2):15.

Schuh S, Holmes J, Ulrich M, Themstrup L, Jemec GB, De Carvalho N,et al. Imaging blood vessel morphology in skin: dynamic optical coherence tomography as a novel potential diagnostic tool in dermatology. Dermatol Ther. 2017;7(2):187-202.

Stanton AW, Drysdale SB, Patel R, Mellor RH, Duff MJ, Levick JR, et al. Expansion of microvascular bed and increased solute flux in human basal cell carcinoma in vivo, measured by fluorescein video angiography. Cancer res. 2003;63(14): 3969-3979.

Piskalkova T. Basal cell carcinoma: new opportunities for pathogenetic therapy. Klin Dermatol Venerol. 2014; 6:4-8. doi: 10.17116/klinderma201464-8

Klyuchareva SV, Ponomarev IV, Pushkareva AE. Numerical Modeling and Clinical Evaluation of Pulsed Dye Laser and Copper Vapor Laser in Skin Vascular Lesions Treatment. J Lasers Med Sci. 2018;10(1):44-49. doi:10.15171/jlms.2019.xx

Ponomarev IV, Topchiy SB, Kazaryan MA, Pushkareva AE, Klyuchareva SV, et al. Numerical Simulation Optimization of Selective Heating of Blood Vessels in “Port-Wine Stains” under Laser Irradiation in Various Modes. B Lebedev Phys Inst. 2018;45(7):204-208. doi:10.3103/S1068335618070035

Abstract Viewed: 404 times
PDF Downloaded: 196 times