Palmoplantar Psoriasis: Treatment with Calcipotriol and Local UVA Radiation Compared with Local PUVA
Journal of Lasers in Medical Sciences,
Vol. 2 No. 1 (2011),
26 April 2011
,
Page 1-5
Abstract
INTRODUCTION: Palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. The most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local PUVA. Frequently, it is a recalcitrant disease. We investigated the efficacy and tolerability of the combination of topical calcipotriol with local UVA radiation in comparison with local PUVA therapy.METHODS: In a total of 43 patients with palmoplantar psoriasis, 33 were given 15 sessions of local UVA radiation and topical calcipotriol and the remainder received 15 sessions of local PUVA (psoralen + UVA radiation).
RESULTS: The statistical analyses of the results showed that the effect and tolerability of both therapeutic modalities are comparable.
CONCLUSION: Combination of topical calcipotriol and local UVA radiation is an optional corticosteroid-free therapeutic modality for palmoplantar psoriasis. It has a comparable effectiveness and tolerability with local PUVA.
- Psoriasis
- palmo-plantar
- Calcipotriol
- Psoralen
- Clinical Trial
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References
Petty A, Balkrishnan R, Rapp S, Fleischer A, Feldman S.Patients with palmoplantar psoriasis have more physical disability and discomfort than patients with other forms of psoriasis: Implications for clinical practice. J Am Acad Dermatol. 2003 August;49(2):271-5.
Farley E, Masrour Sh, McKey J, Menter A. Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool. J Am Acad Dermatol. 2009 Jun;60(6):1024-31.
Adişen E, Tekin O, Gülekon A, Gürer MA. A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients. J Eur Acad Dermatol Venereol. 2009 July;23(7):814-9.
Davis MD, McEvoy MT, el-Azhary RA. Topical psoralenultraviolet A therapy for palmoplantar dermatoses: experience with 35 consecutive patients. Mayo Clin Proc. 1998 May;73(5):407-11.
Egawa K. Topical vitamin D3 derivatives in treating hyperkeratotic palmoplantar eczema: a report of five patients. J Dermatol. 2005 May;32(5):381-6.
Scott LJ, Dunn CJ, Goa KL. Calcipotriol ointment. A review of its use in the management of psoriasis. Am J Clin Dermatol 2001;2(2):95-120.
Roussaki-Schulze AV, Kouskoukis C, Klimi E, Zafiriou E, Galanos A, Rallis E. Objective biophysical findings in patients with sensitive skin. Drugs Exp Clin Res.2005;31(5-6):169-74.
Speight EL, Farr PM. Calcipotriol improves the response of psoriasis to PUVA.Br J Dermatol. 1994 Jan;130(1):79-82.
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