The Immediate Pain-Relieving Effects of Non-Thermal CO2 Laser Therapy on Genital Ulcers of Behcet’s Disease: A Case Report
Journal of Lasers in Medical Sciences,
Vol. 11 No. 1 (2020),
18 January 2020
,
Page 108-111
Abstract
Behçet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. Oral and genital aphthous ulcers are considered as the hallmarks of BD. The genital ulcers of BD may be extremely painful and often refractory to multiple treatments. In addition, they exert a negative impact on the patient’s quality of life. Some investigations have demonstrated the significant and immediate pain-relieving effects of NTCLT (non-thermal CO2 laser therapy) on some oral lesions with no visible adverse effects. In this paper, we report a case of BD whose painful genital ulcers were irradiated with NTCLT and the patient’s pain caused by the ulcers relieved immediately and significantly with no visible complications.
- Behcet’s disease
- Genital ulcers
- CO2 laser
- Non-Thermal CO2 Laser Therapy (NTCLT)
- Pain-relieving effects
- Photobiomodulation
- Low-level laser therapy
How to Cite
References
Davatchi F, Chams-Davatchi C, Shams H, Shahram F, Nadji A, Akhlaghi M, et al. Behcet's disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol. 2017;13(1):57-65. doi: 10.1080/1744666X.2016.1205486.
Alpsoy E. Behcet's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions. J Dermatol. 2016;43(6):620-32. doi: 10.1111/1346-8138.13381.
Alpsoy E, Donmez L, Bacanli A, Apaydin C, Butun B. Review of the chronology of clinical manifestations in 60 patients with Behcet's disease. Dermatology. 2003;207(4):354-6. doi: 10.1159/000074113.
Davatchi F, Shahram F, Chams C, Chams H,Nadji A. Behçet's disease. Acta Medica Iranica. 2005;43(4):233-242.
Kurokawa MS, Yoshikawa H, Suzuki N. Behçet's disease. Clin Exp Med. 2004;4(1):10-20.
Zeidan MJ, Saadoun D, Garrido M, Klatzmann D, Six A, Cacoub P. Behçet’s disease physiopathology: a contemporary review. Auto Immun Highlights. 2016;7(1):4. doi: 10.1007/s13317-016-0074-1.
Davatchi F. Behçet's disease. Int J Rheum Dis. 2018 Dec;21(12):2057-2058. doi: 10.1111/1756-185X.13465.
Lin P, Liang G. Behçet disease: recommendation for clinical management of mucocutaneous lesions. J Clin Rheumatol. 2006;12(6):282-6. doi: 10.1097/01.rhu.0000249894.03016.de.
Mansur AT, Kocaayan N, Serdar ZA, Alptekin F. Giant oral ulcers of Behcet's disease mimicking squamous cell carcinoma. Acta Derm Venereol. 2005;85(6):532-4. doi: 10.1080/00015550510036685.
Kasugai C, WatanabeD, Mizutani K, Masuda Y, Zako M, Mukai T, et al. Infliximab treatment of severe genital ulcers associated with Behçet disease. J Am Acad Dermatol. 2010;62(1):162-4. doi: 10.1016/j.jaad.2009.02.044.
Elad S, Or R, Shapira MY, Haviv A, Galili D, Garfunkel AA, et al. CO2 laser in oral graft-versus-host disease: a pilot study. Bone Marrow Transplant. 2003;32(10):1031-4. doi: 10.1038/sj.bmt.1704272.
Sharon-Buller A, Sela M. CO2-laser treatment of ulcerative lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(3):332-4. doi: 10.1016/j.tripleo.2003.11.012.
Zand N, Ataie-Fashtami L, Djavid GE, Fateh M, Alinaghizadeh MR, Fatemi SM, Arbabi-Kalati F. Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci. 2009;24(4):515-20. doi: 10.1007/s10103-008-0555-1.
Zand N, Ataie-Fashtami L, Fateh M, Mansoori P, Esmaeeli DG, Fatemi SM, et al. Analgesic effects of single session of Non-Ablative CO2 Laser Therapy (NACLT) in major aphthous ulcers: (a preliminary study). Lasers in medicine. 2009;6(4):6-12.
Zand N, Mansouri P, Fateh M, Ataie-Fashtami L, Rezaee Khiabanloo S, Safar F, et al. A new approach to relieve pain in oral lesions of pemphigus vulgaris using the non-ablative, Non-Thermal, CO2 Laser Therapy (NTCLT): preliminary results. J Lasers Med Sci. 2017; 8(1):7-12. doi: 10.15171/jlms.2017.02.
Prasad R.S, Pai A. Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(2):189-93. doi: 10.1016/j.oooo.2013.02.011.
Zand N, Fateh M, Ataie-Fashtami L, Djavid GE, Fatemi SM, Shirkavand A. Promoting wound healing in minor recurrent aphthous stomatitis by non-thermal, non-ablative CO(2) laser therapy: a pilot study. Photomed Laser Surg. 2012;30(12): 719-23. doi: 10.1089/pho.2012.3301.
Zand N. Non-thermal, Non-Ablative CO2 Laser Therapy (NACLT): A new approach to relieve pain in some painful oral diseases. in: Dumitras DC, editor. CO2 laser: optimization and application. Croatia: InTech-Open Access Publisher; 2012. p. 387-414.
Tuner J, Hode L. The New Laser Therapy Handbook. Sweden: Prima books; 2010. Chapter 3.5 : Biostimulation, Laser therapy with high output lasers; p. 67-147.
Tuner J, Hode L. The New Laser Therapy Handbook. Sweden: Prima books; 2010. Chapter 1: Some basic laser physics,Therapeutic lasers; p. 1-47.
Solmaz H, Ulgen Y, Gulsoy M. Photobiomodulation of wound healing via visible and infrared laser irradiation. Lasers Med Sci. 2017;32(4):903-910. doi: 10.1007/s10103-017-2191-0.
Fekrazad R, Mirmoezzi A, Kalhori K, Arany P. The effect of red, green and blue lasers on healing of oral wounds in diabetic rats. J Photochem Photobiol B. 2015;148:242-245. doi: 10.1016/j.jphotobiol.2015.04.018.
Thunshelle C, Hamblin MR. Transcranial Low-Level Laser (Light) Therapy for Brain Injury. Photomed Laser Surg. 2016. 34(12):587-598. doi: 10.1089/pho.2015.4051.
Basirat M. The effects of low power lasers in healing of oral ulcers. J Lasers Med Sci. 2012;3(2): 79-83. doi: 10.22037/jlms.v3i2.3209.
Qadri T, Miranda L, Tunér J, Gustafsson A. The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol. 2005;32(7):714-9. doi: 10.1111/j.1600-051X.2005.00749.x.
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