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  3. Vol. 9 No. 2 (2018): Spring
  4. Original Article

Vol. 9 No. 2 (2018)

April 2018

Therapeutic Effects of Laser on Partial Osteotomy in the Rat Model of Hypothyroidism

  • Niloofar Sefati
  • Hojjat allah Abbaszadeh
  • Fatemeh Fadaee Fath Abadi
  • Mohammad Amin Abdollahifar
  • Abdollah Amini
  • Ali Noori-Zadeh
  • Shahram Darabi
  • Mohsen Norouzain

Journal of Lasers in Medical Sciences, Vol. 9 No. 2 (2018), 27 April 2018 , Page 121-127
Published: 2018-04-27

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Abstract

Introduction: Several experimental studies have displayed positive result for laser radiation on stimulating bone regeneration in recent years. The purpose of this experimental study was to determine low-level laser (LLL) effects on partial bone defects in hypothyroidism male rat.
Methods: Forty male Wistar rats were randomly distributed as below groups: hypothyroidism + laser (Hypo + laser), hypothyroidism (Hypo), and control. Four weeks after surgery, the tibia bone was removed. Biomechanical and histological examinations were performed immediately.
Results: Our results showed significant reduction in the absorption of energy, resistance in bending deformation (bending stiffness), maximum force, high stress load, trabecular bone volume, and number of osteocytes, osteoblasts and osteoclasts in the osteotomy site in hypothyroidism rats compared to hypothyroidism + laser group (P < 0.05).
Conclusion: The results indicated that using laser may improve fracture regeneration and it may accelerate bone healing in hypothyroidism rat.

Keywords:
  • Hypothyroidism
  • Low-level laser
  • Partial osteotomy.
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How to Cite

Sefati, N., Abbaszadeh, H. allah, Fadaee Fath Abadi, F., Abdollahifar, M. A., Amini, A., Noori-Zadeh, A., … Norouzain, M. (2018). Therapeutic Effects of Laser on Partial Osteotomy in the Rat Model of Hypothyroidism. Journal of Lasers in Medical Sciences, 9(2), 121–127. Retrieved from https://journals.sbmu.ac.ir/jlms/article/view/19115
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References

Sefati N, Norouzian M, Abbaszadeh HA, et al. Effects of bone marrow mesenchymal stem cells-conditioned medium on tibial partial osteotomy model of fracture healing in hypothyroidism rats. Iran Biomed J. 2018;22(2):90-98.

Abbaszadeh HA, Tiraihi T, Delshad A, et al. Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine. Tissue Cell. 2014;46(6):462-9.

Abbaszadeh HA, Tiraihi T, Delshad AR, Saghedi Zadeh M, Taheri T. Bone marrow stromal cell transdifferentiation into oligodendrocyte-like cells using triiodothyronine as a inducer with expression of platelet-derived growth factor alpha as a maturity marker. Iran Biomed J. 2013;17(2):62- 70.

Vestergaard P, Mosekilde L. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002;12(5):411-419. doi:10.1089/105072502760043503

Gaitonde DY, Rowley KD, Sweeney LB. Hypothyroidism: an update. Am Fam Physician. 2012;86(3):244-251.

Karimifar M, Esmaili F, Salari A, Kachuei A, Faragzadegan Z, Karimifar M. Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism. J Res Pharm Pract. 2014;3(3):83- 87. doi:10.4103/2279-042x.141099

Garavello I, Baranauskas V, da Cruz-Hofling MA. The effects of low laser irradiation on angiogenesis in injured rat tibiae. Histol Histopathol. 2004;19(1):43-48. doi:10.14670/hh-19.43

Mohsenifar Z, Fridoni M, Ghatrehsamani M, et al. Evaluation of the effects of pulsed wave LLLT on tibial diaphysis in two rat models of experimental osteoporosis, as examined by stereological and real-time PCR gene expression analyses. Lasers Med Sci. 2016;31(4):721-732. doi:10.1007/s10103-016-1916-9

Abbaszadeh HA, Peyvandi AA, Sadeghi Y, et al. Er:YAG Laser and Cyclosporin A Effect on Cell Cycle Regulation of Human Gingival Fibroblast Cells. J Lasers Med Sci. 2017;8(3):143-149. doi:10.15171/jlms.2017.26

Bolognani L, Volpi N. Low power laser enzymology: Reactivation of myosin ATPase by GaAs an HeNe lasers. In: Passarella S, Quagliariello E, eds. Basic and Applied Research in Photobiology and Photomedicine. Bari, Italy: University of Bari; 1991:315-38.

Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO. Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? J Signal Transduct. 2011;2011:792639. doi:10.1155/2011/792639

Arakaki N, Yamashita A, Niimi S, Yamazaki T. Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics. Biomed Res. 2013;34(3):161-166.

Amini A, Pouriran R, Abdollahifar MA, et al. Stereological and molecular studies on the combined effects of photobiomodulation and human bone marrow mesenchymal stem cell conditioned medium on wound healing in diabetic rats. J Photochem Photobiol B. 2018;182:42-51. doi: 10.1016/j.jphotobiol.2018.03.010

Fernandes KR, Ribeiro DA, Rodrigues NC, et al. Effects of low-level laser therapy on the expression of osteogenic genes related in the initial stages of bone defects in rats. J Biomed Opt. 2013;18(3):038002. doi:10.1117/1. jbo.18.3.038002

Abbaszadeh HA, Tiraihi T, Sadeghi Y, et al. Decrease in cavity size and oligodendrocyte cell death using neurosphere-derived oligodendrocyte-like cells in spinal cord contusion model. Iran Biomed J. 2017 Oct 15.

Noorafshan A, Abdollahifar MA, Asadi-Golshan R, Rashidian-Rashidabadi A, Karbalay-Doust S. Curcumin and sertraline prevent the reduction of the number of neurons and glial cells and the volume of rats’ medial prefrontal cortex induced by stress. Acta Neurobiol Exp (Wars). 2014;74(1):44-53.

Ranganath SH, Levy O, Inamdar MS, Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012;10(3):244-258. doi:10.1016/j.stem.2012.02.005

Fadaei Fathabady F, Norouzian M, Azizi F. Effect of hypothyroidism on bone repair in mature female rats. Int J Endocrinol Metab. 2005;3(3):126-9.

Tsourdi E, Rijntjes E, Kohrle J, Hofbauer LC, Rauner M. Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1. Endocrinology. 2015;156(10):3517-3527. doi:10.1210/en.2015-1073

Paraguassu GM, Xavier FC, Cangussu MC, et al. Effect of laser phototherapy (lambda660 nm) on type I and III collagen expression during wound healing in hypothyroid rats: an immunohistochemical study in a rodent model. Photomed Laser Surg. 2014;32(5):281-288. doi:10.1089/ pho.2013.3604

Chang W, Kim R, Park SI, et al. Enhanced Healing of Rat Calvarial Bone Defects with Hypoxic Conditioned Medium from Mesenchymal Stem Cells through Increased Endogenous Stem Cell Migration via Regulation of ICAM- 1 Targeted-microRNA-221. Mol Cells. 2015;38(7):643-650. doi:10.14348/molcells.2015.0050

Ogata K, Katagiri W, Osugi M, et al. Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model. Bone. 2015;74:95-105. doi:10.1016/j.bone.2015.01.011

Barbosa D, Villaverde AG, LoschiavoArisawa EA, de Souza RA. Laser therapy in bone repair in rats: analysis of bone optical density. Acta Ortop Bras. 2014;22(2):71-74. doi:10.1590/1413-78522014220200438

Medalha CC, Amorim BO, Ferreira JM, et al. Comparison of the effects of electrical field stimulation and low-level laser therapy on bone loss in spinal cord-injured rats. Photomed Laser Surg. 2010;28(5):669-674. doi:10.1089/ pho.2009.2691

Sella VR, do Bomfim FR, Machado PC, da Silva Morsoleto MJ, Chohfi M, Plapler H. Effect of low-level laser therapy on bone repair: a randomized controlled experimental study. Lasers Med Sci. 2015;30(3):1061-1068. doi:10.1007/ s10103-015-1710-0

Nicola RA, Jorgetti V, Rigau J, Pacheco MT, dos Reis LM, Zangaro RA. Effect of low-power GaAlAs laser (660 nm) on bone structure and cell activity: an experimental animal study. Lasers Med Sci. 2003;18(2):89-94. doi:10.1007/ s10103-003-0260-z

Mostafavinia A, Masteri Farahani R, Abbasian M, et al. Effect of Pulsed Wave Low-Level Laser Therapy on Tibial Complete Osteotomy Model of Fracture Healing With an Intramedullary Fixation. Iran Red Crescent Med J. 2015;17(12):e32076. doi:10.5812/ircmj.32076

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