Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis
Journal of Lasers in Medical Sciences,
Vol. 8 No. 1 (2017),
25 January 2017
,
Page 46-50
Abstract
Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT.
Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis. Cytotoxicity was assessed in J774.A1 macrophages.
Results: RB derivates RBMET (IC50 9.83 μM), and RBBUT (IC50 45.08 μM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index.
Conclusion: The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment.
- Cutaneous leishmaniasis
- Photodynamic therapy
- Leishmania amazonensis
- Xanthenes
- Rose Bengal B.
How to Cite
References
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Manual de Vigilância da Leishmaniose Tegumentar Americana. 2nd ed. Brasília: Editora do Ministério da Saúde; 2013. http://bvsms.saude.gov.br/bvs/publicacoes/manual_ vigilancia_leishmaniose_tegumentar_americana_2edicao. pdf.
Leishmaniasis. Word Health Organization website. http:// goo.gl/iSw9KC. Accessed September 20, 2014. Published 2014.
Leishmaniose. Word Health Organization website. http:// goo.gl/5mOxJT. Accessed September 20, 2014.
Evangelou G, Krasagakis K, Giannikaki E, Kruger- Krasagakis S, Tosca A. Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy. Photodermatol Photoimmunol Photomed. 2011;27:254-256. doi:10.1111/j.1600- 0781.2011.00610.x.
Dutta S, Waki K, Chang KP. Combinational sensitization of Leishmania with uroporphyrin and aluminum phthalocyanine synergistically enhances their photodynamic inactivation in vitro and in vivo. Photochem Photobiol. 2012;80:620-625. doi:10.1111/ j.1751-1097.2012.01076.x.
Barbosa AF, Sangiorgi BB, Galdino SL, Barral-Netto M, Pitta IR, Pinheiro AL. Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis. Lasers Surg Med. 2012;44:850-855. doi:10.1002/lsm.22099
Pizinger K, Cetkovska P, Kacerovska D, Kumpova M. Successful treatment of cutaneous leishmaniasis by photodynamic therapy and cryotherapy. Eur J Dermatol. 2009;19(2):172-173. doi:10.1684/ejd.2008.0587.
Sbeghen MR, Voltarelli EM, Cmpois TG, et al. Topical and intradermal efficacy of photodynamic therapy with methylene blue and light-emitting diode in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis. J Lasers Med Sci. 2015;6(3):106-101.
Zollinger H. Color chemistry: syntheses, properties, and applications of organic dyes and pigments. Wiley-VCH; 1991.
Gilbert A, Baggott JE. Essentials of molecular photochemistry. CRC Press; 1991.
Peloi LS, Biondo CE, Kimura E, et al. Photodynamic therapy for American cutaneous leishmaniasis: the efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis. Exp Parasitol. 2011;128:353-356. doi:10.1016/j.exppara.2011.04.009.
Escobar P, Hernandez IP, Rueda CM, Martinez F, Paez E. Photodynamic activity of aluminium (III) and zinc (II) phthalocyanines in Leishmania promastigotes. Biomedica. 2006;26(1):49-56.
Demarchi IG, Tomazella MV, Terron MS, et al. Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia. Exp Parasitol. 2015;157:128-137. doi:10.1016/j. exppara.2015.06.014.
Honda PA, Ferreira ICP, Cortez DAG, et al. Efficacy of components from leaves of Calophyllum brasiliense against Leishmania (Leishmania) amazonensis. Phytomedicine. 2010;17:333-338. doi:10.1016/j.phymed.2009.08.011.
Abreu Miranda M, Tiossi RF, da Silva MR, et al. In vitro leishmanicidal and cytotoxic activities of the glycoalkaloids from Solanum lycocarpum (Solanaceae) fruits. Chem Biodivers. 2013;10(4):642-648. doi:10.1002/ cbdv.201200063.
Almeida L, Alves KF, Maciel-Rezende CM, et al. Benzophenone derivatives as cysteine protease inhibitors
and biological activity against Leishmania(L.) amazonensis amastigotes. Biomed Pharmacother. 2015;75:93-99. doi:10.1016/j.biopha.2015.08.030.
MV, de Souza PS, de Queiroz AC, et al. Synthesis, leishmanicidal activity and theoretical evaluations of a series of substituted bis-2-hydroxy-1,4-naphthoquinones. Molecules. 2014;19(9):15180-15195. doi:10.3390/ molecules190915180.
Gontijo VS, Espuri PF, Alves RB, et al. Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines. Eur J Med Chem. 2015;101:24- 33. doi:10.1016/j.ejmech.2015.06.005.
Garcia M, Mozonte L, Schull R, Herrera P. Activity of Cuban Plants Extracts against Leishmania amazonensis. ISRN Pharmacol. 2012 Cabanillas BJ, Le Lamer AC, Olagnier D, et al. Leishmanicidal compounds and potent PPARgamma activators from Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl. J Ethnopharmacol. 2014;157:149-155. doi:10.1016/j. jep.2014.09.010.
Araujo;2012:104540. doi:10.5402/2012/104540
Dutra LA, de Almeida L, Passalacqua TG, et al. Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives. Antimicrob Agents Chemother. 2014;58(8):4837-4847.
Yao M, Yaroslavsky A, Henry FP, Redmond RW, Kochevar IE. Phototoxicity is not associated with photochemical tissue bonding of skin. Lasers Surg Med. 2010;42(2):123- 131. doi:10.1002/lsm.20869.
Yang P, Yao M, De Martelaere SL, Redmond RW, Kochevar IE. Light-activated sutureless closure of wounds in thin skin. Lasers Surg Med. 2012;44(2):163-167. doi:10.1002/ lsm.21137.
- Abstract Viewed: 943 times
- PDF Downloaded: 478 times