Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation
Journal of Lasers in Medical Sciences,
Vol. 8 No. 3 (2017),
,
Page 118-122
Abstract
Introduction: The purpose of this project is to develop a mathematical model to investigate light distribution and study effective parameters such as laser power and irradiated time to get the optimal laser dosage to control hyperthermia. This study is expected to have a positive impact and a better simulation on laser treatment planning of biological tissues. Moreover, it may enable us to replace animal tests with the results of a COMSOL predictive model.Methods: We used in this work COMSOL5 model to simulate the light diffusion and bio-heat equation of the mouse tissue when irradiated by 980 nm laser diode and the effect of different parameters (laser power, and irradiated time) on the surrounding tissue of the tumor treatment in order to prevent damage from excess heat
Results: The model was applied to study light propagation and several parameters (laser power, irradiated time) and their impact on light-heat distribution within the tumor in the mouse back tissue
The best result is at laser power 0.5 W and time irradiation 0.5 seconds in order to get the maximum temperature hyperthermia at 52°C.
Conclusion: The goal of this study is to simulate a mouse model to control excess heating of tissue and reduce the number of animals in experimental research to get the best laser parameters that was safe for use in living animals and in human subjects.
- Laser irradiation
- Diode laser
- Optical-thermal
- Experimental animal
- Temperature distribution
- Light propagation
How to Cite
References
Emmanuel Kengne، Ahmed Lakhssassi، Remi Vaillancourt. (2012)." Temperature Distributions for Regional Hypothermia Based on Nonlinear Bioheat Equation of Pennes Type: Dermis and Subcutaneous Tissues"، Applied Mathematics، 3، PP 217-224.
Luong QM, Dams SD. The Light Distribution In Skin Of A 976nm Laser Diode Using Different Parameter Sets In Monte Carlo Simulations. Koninklijke Philips Electronics N.V. 2009.
Welch AJ, van Gemert MJC. Optical-Thermal Response of Laser-Irradiated Tissue. ISBN: 978-90-481-8830-7 (Print) 978-90-481-8831-4 (Online)
Demésy G, Gallais L, Commandré M. Tridimensional multiphysics model for the study of photo-induced thermal effects in arbitrary nano-structures. J Europ Opt Soc Rap Public. 2011; 6.
Orringer JS, Voorhees JJ, Hamilton T, Hammerberg C, Kang S, Johnson TM, et al. Dermal matrix remodeling after nonablative laser therapy. J Am Acad Dermatol. 2005; 53: 775–82.
Anderson RR. Coetaneous Laser Surgery, Second edition.
Rajan Dua، Suman Chakraborty. (2005). "A novel modeling and simulation technique of photo-thermal interactions between lasers and living biological tissues undergoing multiple changes in phase" computers in biology and medicine، 35، 447-462.
Shafirstein G, Bäumler W, Lapidoth M, Ferguson S, North PE, Waner M. A new mathematical approach to the diffusion approximation theory for selective photothermolysis modeling and its implication in laser treatment of port-wine stains. Lasers Surg Med. 2004;34:335-47.
Ng EY, Ooi EH. FEM simulation of the eye structure with bioheat analysis. Comput Methods Programs Biome. 2006; 82(3):268-76.
Dombrovsky LA, Timchenko V, Quist A. A Simplified model of LASER hyperthemia of superficial tumors including variation of human tissue optical properties with thermal damage. International Mechanical Engineering Congress. 2012
Tzu-Ching Shih، Ping Yuan، Win-Li Lin، Hong-Sen Kou. (2007)." Analytical analysis of the Pennes bioheat transfer equation with sinusoidal heat flux condition on skin surface"، Medical Engineering and Physics، 29، PP 946–953.
Rossi F, Pini R, Menabuoni L. 3D Simulation and Experimental Comparison of Temperature Dynamics Laser Welded Cornea. Proceedings of the COMSOL Users Conference. 2006.
Ying Hea, Minoru Shirazakib, Hao Liuc, Ryutaro Himenoa, Zhigang Sund, A numerical coupling model to analyze the blood flow, temperature, and oxygen transport in human breast tumor under laser irradiation, Computers in Biology and Medicine. 2006; 36: 1336–1350.
Jacques SL. Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58 (11) R37–R61.
Dua R, Chakraborty S. A novel modeling and simulation technique of photo-thermal interactions between lasers and living biological tissues undergoing multiple changes in phase. Comput Biol Med. 2005;35(5): 447-62.
- Abstract Viewed: 1165 times
- PDF Downloaded: 950 times
