Successful Treatment of Unilateral Klippel-Trenaunay Syndrome With Pulsed-Dye Laser in a 2-Week Old Infant
Journal of Lasers in Medical Sciences,
Vol. 8 No. 2 (2017),
8 April 2017
,
Page 98-100
Abstract
Introduction: Klippel–Trenaunay syndrome (KTS) is a rare congenital mesodermal abnormality characterized by varicose veins, cutaneous capillary malformation, as well as bone and soft tissue hypertrophy.
Case Report: A 2-week-old female infant presented to our clinic because of vascular nevus and progressive enlargement of her right extremities and trunk since birth. The patient was treated with 595-nm pulsed-dye laser (PDL). Her port-wine stain (PWS) disappeared completely after third PDL session and the soft tissue hypertrophy stopped. The patient experienced neither recurrence nor any change in size after 7 years of follow up.
Conclusion: PDL can treat KTS completely with no reccurence if it is used in “early stage” of disease.
- Klippel–Trenaunay syndrome
- Laser
- Port-wine stain
- Vascular malformation.
How to Cite
References
Kihiczak GG, Meine JG, Schwartz RA, Janniger CK. Klippel-Trenaunay syndrome: a multisystem disorder possibly resulting from a pathogenic gene for vascular and tissue overgrowth. Int J Dermatol. 2006;45:883-890. doi:10.1111/j.1365-4632.2006.02940.x.
Parkes-Weber F. Angioma formation in connection with hypertrophy of limbs and hemi-hypertrophy. Br J Dermatol Syph. 1907;19:231–35.
Mullins JF, Naylor D, Redetzki J. The Klippel–Trenaunay– Weber syndrome. Arch Dermatol. 1962;86:202–206.
Gloviczki P, Hollier LH, Telander RL, Kaufman B, Bianco AJ, Stickler GB. Surgical implications of Klippel–Trénaunay syndrome. Ann Surg. 1983;197:353–362.
Lamar LM, Farber GA, O’Quinn SE. Klippel-Trenaunay- Weber Syndrome. Arch Dermatol. 1965;91:58–59.
Samuel M, Spitz L. Klippel–Trenaunay syndrome:clinical features, complications and management in children. Br J Surg. 1995;82:757–61.
Lindenauer MS. Congenital arterio-venous fistula and the Klippel–Trenaunay syndrome. Ann Surg. 1971;174:248– 263.
Castro-Magana M, Hernandez-Pérez E. Klippel– Trenaunay–Weber syndrome:a case occurring in the ear and associated with arteriovenous fistulas. Cutis. 1980;25:501–502.
Chu ST, Han YH, Koh JA, et al. A case of Klippel- Trenaunay syndrome with acute submassive pulmonary thromboembolism treated with thrombolytic therapy. J Cardiovasc Ultrasound. 2015;23():266-270. doi:10.4250/ jcu.2015.23.4.266.
Gloviczki P, Driscoll DJ. Klippel-Trenaunay syndrome: current management. Phlebology. 2007;22:291-298.
Sung HM, Chung HY, Lee SJ, et al. Clinical Experience of the Klippel-Trenaunay Syndrome. Arch Plast Surg. 2015;42:552-558.
Marques L, Nunez-Cordoba JM, Aguado L, et al. Topical rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge–Weber syndrome: phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial. J Am Acad Dermatol. 2015;72:151–158.e1. doi:10.1016/j. jaad.2014.10.011.
Woo WK, Handley JM. Does fluence matter in the laser treatment of port-wine stains? Clin Exp Dermatol. 2003;28:556-57.
Gao L, Phan S, Nadora DM, et al. Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways. Lasers Surg Med. 2014;46(9):679-688. doi:10.1002/lsm.22296.
Nguyen A, Hoang V, Laquer V, Kelly KM. Angiogenesis in cutaneous disease: part I. J Am Acad Dermatol. 2009;61:921-942.
Laquer VT, Hevezi PA, Albrecht H, et al. Microarray analysis of port wine stains before and after pulsed dye laser treatment. Lasers Surg Med. 2013;45(2):67-75. doi:10.1002/lsm.22087.
Savas JA, Ledon JA, Franca K. Pulsed dye laser-resistant port-wine stains:Mechanisms of resistance and implications for treatment. Br J Dermatol. 2013;168:941- 953. doi:10.1111/bjd.12204.
Phung TL, Oble DA, Jia W, et al. Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks. Lasers Surg Med. 2008;40:1-5.
Katugampola GA, Lanigan SW. Five years’ experience of treating port wine stains with the flashlamp-pumped pulsed dye laser. Br J Dermatol. 1997;137:750-754.
Jia W, Sun V, Tran N, et al. Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment. Lasers Surg Med. 2010;42:105-112. doi:10.1002/lsm.20890.
Ortiz AE, Nelson JS. Port-wine stain laser treatments and novel approaches. Facial Plast Surg. 2012;28:611-620.
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