Original Articles

Antioxidative Effects of Isoflurane and Propofol on Serum Levels of Catalase, Glutathione and Superoxide Dismutase in Craniotomy for Supratentorial Tumor

Masoud Nashibi, Parisa Sezari, Kamran Mottaghi, Samaneh Yeganeh-Khah, Farhad Safari

Journal of Cellular & Molecular Anesthesia, Vol. 4 No. 2 (2019), 29 October 2019 , Page 33-40

Background: Surgical stresses can reduce the activity level of antioxidant enzymes. The brain is one of the vital organs of the body and yet vulnerable to oxidative damage. Considering the antioxidative effects of anesthetics, this study aimed to compare the effect of isoflurane and propofol on the serum levels of catalase, glutathione peroxidase and superoxide dismutase in patients who experienced craniotomy due to supratentorial tumor.Methods and materials: This randomized clinical trial was performed on 40 patients with supratentorial tumor craniotomy in Loghman Hakim hospital in Tehran (capital city of Iran), who were randomly assigned to receive propofol and isoflurane. Data were collected using a questionnaire including age, sex, serum glutathione peroxidase level, serum superoxide dismutase level, serum catalase levels, duration of surgery, and fentanyl. Data were analyzed using SPSS-21 software, Chi-Square, Paired T-test, ANOVA, independent t-test, Kruskal-Wallis and Wilcoxon tests.Results: Increasing in serum catalase level after surgery was significant in propofol group (p=0.002), but not significant in isoflurane group. Reduction of serum glutathione peroxidase level after surgery was significant in the isoflurane group (p=0.003), but not significant in propofol group. Reduction of serum level of superoxide dismutase after surgery was not significant in both groups. Serum levels of catalase, glutathione and superoxide dismutase were not significantly correlated with age, sex, fentanyl and duration of surgery.Conclusion: The study showed that serum catalase levels increased in the propofol group after surgery. However, serum glutathione peroxidase levels decreased in the isoflurane group after surgery. Changes in serum level of superoxide dismutase after surgery were not related to the type of anesthetic drug.

Keywords: Isoflurane, Propofol, Catalase, Glutathione peroxidaase, Superoxide dismutase, Craniotomy

Effect of L-Carnitine on Troponin, IL6 and HS– CRP levels after Coronary Artery Bypass Graft Surgery

Ali Khalili, Kamal Fani, Mahdyieh Naziri, Mahnoosh Foroughi, Farzaneh Dastan, Ali Dabbagh, Hosein Ali Jelveh Moghadam, Alireza Jahangirifard

Journal of Cellular & Molecular Anesthesia, Vol. 4 No. 2 (2019), 29 October 2019 , Page 41-48

Background: L-carnitine seems to be able to prevent complications after heart surgery using Cardiopulmonary bypass (CPB) and the adverse effects of pump usage. This study aimed to evaluates the effects of L-carnitine on cardiac biomarkers and operation characteristics after coronary artery bypass graft (CABG) surgery.Methods and materials: In this randomized triple-blinded, sixty patients undergoing elective CABG surgery were divided into three equal groups to receive 2gr oral L-carnitine (group A), 5gr oral L-carnitine (group B) and placebo (group C) 2 hours before surgery. IL-6, creatinine, and high sensitivity C-reactive protein (HS–CRP) levels, CK-MB, cardiac troponin and inotrope administration in ICU or after CPB were recorded for all patients at baseline levels and at 8 or 24 hours postoperatively.Results: There was an evidence of a significant difference in CPK-MB level and number of red blood cell packed used in group A was lower than group C (p<0.05). The cardiac troponin level 8 hours after surgery significantly decreased in two treatment groups in comparison to group C (p<0.05). The need for inotropic support after weaning from CPB, in B group was statistically higher than C group (p=0.021).Conclusion: Although L-carnitine adjunct therapy appears not to be associated with IL-6 and HS–CRP levels, it had beneficial effects on cardiac troponin and CPK-MB levels.




Keywords: Coronary artery bypass graft surgery, IL-6, HS–CRP levels, L-carnitine, Troponin

Evaluation of an arterial blood sampling device and its function in accelerating and facilitating blood sampling

Ghasem Soltani, Arash Peivandi Yazdi, Maliheh Ziaee, Alireza Hoseini, Mohamood Khorsand, Farzaneh Farrokhseir, Seyed Javad Purafzali Firuzabadi

Journal of Cellular & Molecular Anesthesia, Vol. 4 No. 2 (2019), 29 October 2019 , Page 49-54

Background: Arterial blood sampling is among the basic standards in critically ill patients. The aim of this study was to examine an inventive sampling device in facilitating arterial blood sampling in comparison to the conventional method using an insulin syringe.Methods and materials: This randomized interventional clinical trial was performed on 100 patients admitted to Qaem and Imam Reza Hospitals in Mashhad in 2016 for whom two arterial blood gas (ABG) samples were indicated. The patients were randomly selected by the visiting operator on a daily basis. The operator visited the hospital on certain days and took two samples from the selected patients.Results: The patients' mean age was 45.31±16.15 years. In the insulin syringe group, venous blood gas sampling was in 24% and arterial sample in 76%. In the designed device group, same figures were 12.1% and 87.9%, respectively. Sampling score (p=0.01), unsuccessful attempts with and without needle removal from the skin (p=0.01), and need for vertical and horizontal needle displacement for sampling (p=0.01) were significantly differed between the two groups. Localized swelling score and its size, localized bruising, palpable arterial spasm and the spasm duration was significantly less for the inventive device (p<0.05). Satisfaction score of patients and operator were significantly higher in the device group (p=0.01).Conclusion: The study device had desirable function in facilitating and accelerating arterial blood sampling. Its application can be further approved by future studies.

Keywords: Arterial blood sampling, Facilitated sampling, Accelerated sampling, Intensive Care Unit

Comparison of Continuous Infusions of Ketorolac, Paracetamol and Parecoxib for postoperative pain management in orthopedic lower limb surgery under spinal anesthesia

Mehran Rezvani Habibabadi, Ahmad Yaraghi, Ferial Hayati, Faranak Hayati, Behnam Hosseini, Seyed Mohammad Seyed Alshohadaei

Journal of Cellular & Molecular Anesthesia, Vol. 4 No. 2 (2019), 29 October 2019 , Page 55-62

Background: the effect of three drugs; Ketorolac, Paracetamol and Parecoxib, on patients undergoing lower extremities orthopedic surgeries were compared regarding their analgesic effects.Materials and methods: 140 patients undergoing lower extremities orthopedic surgery were assigned in four groups: 35 patients in each. In Parecoxib group, 20 mg of the drug was infused in 20 minutes and then 60 mg of Parecoxib was added to the pump and the rest of the pump was filled with normal saline up to100 ml. In Ketorolac group, 15 mg Ketorolac was infused in 20 minutes and then, 45 mg of Ketorolac was added into the pump and the rest of the pump was filled with normal saline up to 100 ml. In Paracetamol group 500 mg Paracetamol was infused in 20 minutes and then 1500 mg of Paracetamol was added into the pump and the rest of the pump was filled with normal saline up to 100 ml. In the placebo group, infusion pump was filled with 100 ml of normal saline.Results: Pain score was not significantly different between Paracetamol and placebo groups. Six hours after operation, only the difference in the mean pain scores between Parecoxib and placebo groups was significant. However, 12 and 18 hours after operation, the mean pain score in Parecoxib group was significantly lower than Paracetamol and placebo groups (p<0.05). Nevertheless, 24 hours after operation, the mean pain score in Parecoxib and Ketorolac groups were significantly lower than placebo group (p<0.05).Conclusion: The results showed that Parecoxib could be used for postoperative pain management in orthopedic lower limb surgeries. Ketorolac and Paracetamol could reduce morphine requirements in similar patterns.

Keywords: Ketorolac, Paracetamol, Parecoxib

Brief Communications

Anesthetic considerations in a patient with Psoriasis undergoing CABG surgery

Mahmud Beheshti Monfared, Zahra Ansari Avval, Pardis Soltanpoor, Naeime Gholizadeh, Samira Rajaei, Ali Dabbagh

Journal of Cellular & Molecular Anesthesia, Vol. 4 No. 2 (2019), 29 October 2019 , Page 63-66

A 51 years old man with a 30 years history of psoriasis was scheduled for elective CABG due to 3 vessels coronary artery involvement and the resulting ischemic heart diseases. The psoriatic lesions were on the limbs and posterior parts of the trunk. The perioperative period was eventless and the patient was under care in postoperative cardiac ICU ward. He was discharged home 10 days after the operation with stable psoriasis state.

Letter to the Editor