The Association of Transcript Levels of Proinflammatory Cytokines in Adipose Tissues with Various Adiposity Indices in Women with Obesity
Archives of Medical Laboratory Sciences,
Vol. 8 (2022),
10 Dey 2022
,
Page 1-10 (e1)
https://doi.org/10.22037/amls.v8.35941
Abstract
Background and Aim: To investigate the association of adipose tissue transcript levels of IL-1β, IL-6, TNF-α, and MCP-1 with various adiposity indices in obese women.
Methods: Real-time PCR was carry out to investigate the mRNA expression level of the mentioned genes in VAT and SAT from all participants.
Results: The results presented higher mRNA levels of IL-6 and MCP-1 in SAT and VAT of obese women, compared to normal-weight women. As well, results showed a positive correlation of IL-6 and MCP-1 with HOMA-IR. Obesity indices including BMI, hip, and WHtR were considerably higher in the obese group in comparison with the control group. More importantly, we observed a positive correlation of mRNA expression of these pro-inflammatory factors in adipose tissues with some obesity indices.
Conclusion: We have shown here that adipose tissue transcript levels of pro-inflammatory cytokines were significantly higher in obese participate than non-obese participants. In obese individuals, this proinflammatory molecules was significantly correlated with various obesity indices. These results suggest that targeting obesity and adipose tissue could prevent the high expression of cytokine.
*Corresponding Author: Dr. Mehrnoosh Shanaki; Email: shanaki_m@sbmu.ac.ir
Please cite this article as: Aliabadi M, Samavarchi Tehrani S, Shanaki M. The Association of Transcript Levels of Proinflammatory Cytokines in Adipose Tissues with Various Adiposity Indices in Women with Obesity. Arch Med Lab Sci. 2022;8:1-10 (e1). https://doi.org/10.22037/amls.v8.35941
- Adipose Tissue
- Pro-inflammatory Cytokines
- Adiposity Indices
- Anthropometric Index
- Obesity
How to Cite
References
Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obesity reviews. 2010;11(1):11-8.
Wu H, Ballantyne CM. Skeletal muscle inflammation and insulin resistance in obesity. The Journal of clinical investigation. 2017;127(1):43.
Zhu Q, An YA, Kim M, Zhang Z, Zhao S, Zhu Y, et al. Suppressing Adipocyte Inflammation Promotes Insulin Resistance in Mice. Molecular Metabolism. 2020:101010.
Conway B, Rene A. Obesity as a disease: no lightweight matter. Obesity Reviews. 2004;5(3):145-51.
Kelly T, Yang W, Chen C-S, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. International journal of obesity. 2008;32(9):1431-7.
Rahmani A, Sayehmiri K, Asadollahi K, Sarokhani D, Islami F, Sarokhani M. Investigation of the prevalence of obesity in Iran: a systematic review and meta-analysis study. 2015.
Li G, Wu H-k, Wu X-w, Cao Z, Tu Y-c, Ma Y, et al. The feasibility of two anthropometric indices to identify metabolic syndrome, insulin resistance and inflammatory factors in obese and overweight adults. Nutrition. 2019;57:194-201.
Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10.
Jabłonowska-Lietz B, Wrzosek M, Włodarczyk M, Nowicka G. New indexes of body fat distribution, visceral adiposity index, body adiposity index, waist-to-height ratio, and metabolic disturbances in the obese. Kardiologia Polska (Polish Heart Journal). 2017;75(11):1185-91.
Alexopoulos N, Katritsis D, Raggi P. Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis. Atherosclerosis. 2014;233(1):104-12.
Ping Z, Pei X, Xia P, Chen Y, Guo R, Hu C, et al. Anthropometric indices as surrogates for estimating abdominal visceral and subcutaneous adipose tissue: a meta-analysis with 16,129 participants. Diabetes research and clinical practice. 2018;143:310-9.
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 2000;148(2):209-14.
Wallace D, Hahn BH. Dubois' Lupus Erythematosus and Related Syndromes E-Book: Expert Consult-Online: Elsevier Health Sciences; 2012.
Kaneko N, Kurata M, Yamamoto T, Morikawa S, Masumoto J. The role of interleukin-1 in general pathology. Inflammation and regeneration. 2019;39(1):1-16.
Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine & growth factor reviews. 2011;22(4):189-95.
Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. Journal of interferon & cytokine research. 2009;29(6):313-26.
Chawla A, Nguyen KD, Goh YS. Macrophage-mediated inflammation in metabolic disease. Nature Reviews Immunology. 2011;11(11):738-49.
Maury E, Brichard S. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and cellular endocrinology. 2010;314(1):1-16.
Rodríguez-Hernández H, Simental-Mendía LE, Rodríguez-Ramírez G, Reyes-Romero MA. Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. International journal of endocrinology. 2013;2013.
Skurk T, Van Harmelen V, Lee Y-M, Wirth A, Hauner H. Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients. Hormone and metabolic research. 2002;34(11/12):659-63.
Ali MA. Automatic generation of truss models for the optimal design of reinforced concrete structures: Cornell University; 1997.
Shimomura I, Funahasm T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty. Nature medicine. 1996;2(7):800-3.
Zagotta I, Dimova EY, Debatin K-M, Wabitsch M, Kietzmann T, Fischer-Posovszky P. Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue. Frontiers in Pharmacology. 2015;6(79).
Fain JN, Madan AK. Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes. Metabolism. 2005;54(2):220-6.
Stępień M, Stępień A, Wlazeł RN, Paradowski M, Banach M, Rysz J. Obesity indices and inflammatory markers in obese non-diabetic normo-and hypertensive patients: a comparative pilot study. Lipids in health and disease. 2014;13(1):1-10.
Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al. Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes care. 2010;33(4):920-2.
Amato MC, Giordano C. Visceral adiposity index: an indicator of adipose tissue dysfunction. International journal of endocrinology. 2014;2014.
Al‐Daghri NM, Al‐Attas OS, Alokail MS, Alkharfy KM, Charalampidis P, Livadas S, et al. Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances. European journal of clinical investigation. 2013;43(2):183-9.
Agraval N, Chitrika A, Bhattacharjee J, Jain S. Correlations of tumor necrosis factor-α and interleukin-6 with anthropometric indices of obesity and parameters of insulin resistance in healthy north Indian population. JIACM. 2011;13:196-204.
Khan R, Haque S, Quaiser S. The inflammatory markers: C-Reactive Protein and TNF-α predict Cardiovascular risks in obese North Indian subjects. Biomedical Research (0970-938X). 2011;22(4).
Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes research and clinical practice. 2005;69(1):29-35.
Arbel Y, Birati EY, Shapira I, Finn T, Berliner S, Rogowski O. Comparison of different anthropometric measurements and inflammatory biomarkers. International journal of inflammation. 2012;2012.
Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev. 2012;13(3):275-86.
- Abstract Viewed: 346 times
- PDF Downloaded: 220 times