Archives of Medical Laboratory Sciences

Background and Aim: Laboratory studies have pointed to the key role of hepatic glucose release in fasting glucose levels, especially in patients with diabetes. This study was conducted with the aim of determining the effect of resistance training on hepatocyte PEPCK and FTO expression in the rats with type 2 diabetes (T2D).

Methods: For this purpose, 28 male Wistar rats (220 ± 10 grams) were fed a high-fat diet (HFD) in order to induce obesity. Among them, T2D induced in 14 rats by intraperitoneal injection of Streptozotocin (STZ) (30 ml/kg). Finally, the studied rats were divided into 4 groups with equal number: 1) control healthy, 2) resistance healthy, 3) control diabetic, and 4) resistance diabetic. The rat in resistance healthy and diabetic groups was completed 8 weeks resistance training (5 times/weekly) and control rats remained non-training. 48 hours after exercise intervention, fasting blood glucose, and hepatocyte PEPCK and FTO expression were compared by two-way analysis of variance and Tukey's post hoc test. Level of significance was set at P < 0.05.

Results: Resistance training in resistance diabetes group resulted in significant decrease in fasting glucose (P = 0.001), FTO expression (P = 0.024) and PEPCK expression (P = 0.002) compared to control diabetes group. No significant differences were observed in mentioned variables between control and resistance healthy groups (P > 0.05).

Conclusion: Improvement of blood glucose following resistance training is likely to be rooted in decrease the hepatic glucose release induced by reducing the gluconeogenic genes expression following this training method.

Keywords: Type 2 diabetes; Hepatic Gene expression; Resistance Training; Gluconeogenesis;  Type 2 Diabetes Rat Model; Streptozotocin (STZ) Induced Diabetes Mellitus.

^*Corresponding Author: Heshmatolah Parsian; Email: h.parsian@iau.ac.ir; parsian52heshmat@gmail.com;; ORCID ID:  0009-0009-5088-4696

Please cite this article as: Ahmadian A, Parsian H, Hosseini SA, Soheili S, Ershadi R. Improvement of Fasting Glucose Following Resistance Training with Emphasis on The Some Gluconeogenic Genes Expression in Type 2 Diabetes Rat Model. Arch Med Lab Sci. 2026;12:1-7 (e1). https://doi.org/10.22037/amls.v12.47527

Background and Aim: Recent studies have indicated the effectiveness of exercise training combined with antioxidant supplements on cardiovascular function in healthy and morbidly obese individuals. In the present study, the effect of CX Works training (CX) with and without inulin intake was evaluated on some markers of vascular function in women with metabolic syndrome.

Methods: In current semi-experimental study, 48 adult women with metabolic syndrome were randomly divided into 4 groups with 8 weeks intervention: CX training (every other day), inulin (10 grams/daily); combined (CX/inulin) and control (no intervention) groups. Serum Vascular endothelial growth factor (VEGF) and homocysteine after an overnight fast were measured in all groups (pre-training) and measurements were repeated 48 hours after the last exercise session (post-training).

Results: Compared to the control group, serum VEGF in the other groups increased significantly (p<0.05). Serum VEGF in the combined group also increased compared to the CX and inulin groups (p<0.05). Serum homocysteine in the combined group increased significantly compared to the other groups (p<0.05).

Conclusion: Based on the findings, inulin consumption during CX exercises is associated with greater endothelial effects than either of them alone in patients with metabolic syndrome. Measurement of other markers of vascular function is recommended for better conclusions.

Keywords: Vascular Endothelial Function; CX Training; Inulin; Metabolic Syndrome.

^*Corresponding Author: Shahram Soheili; Email: s.sohaili@iau.ac.ir; sohaily52shahram@gmail.com; ORCID ID: 0000-0002-6161-9048

Please cite this article as: Khodabandehlu F, Soheili S, Parsian H, Ershadi R, Azarbayjani MA. The Impact of CX Training Combined with Inulin Consumption on Some Vascular Function Indices in Women with Metabolic Syndrome. Arch Med Lab Sci. 2026;12:1-7 (e2). https://doi.org/10.22037/amls.v12.47582