Relationship between maternal serum C - reactive protein
Advances in Nursing & Midwifery,
دوره 24 شماره 85 (2015),
2 ژوئیهٔ 2015
,
صفحه 31-38
https://doi.org/10.22037/anm.v24i85.8111
چکیده
Abstract
Abstract Background:
It is hypothesized that GDM may be a systemic inflammation mediated by cytokine.
This case-control study was designed to investigate correlation between C-reactive protein (CRP) and
gestational diabetes mellitus (GDM).
Method:
In a case-control study, a convenient sample of 60 pregnant women with GDM (case group) and
120 pregnant women without GDM (control group) who attended to GDM and prenatal clinics and women
clinics of Ayatollah Taleghani and Mahdiyeh Hospitals were included. Serum level of CRP measured by
qualitative and quantitative methods was compared in two groups. Demographic information and
reproductive history were obtained by interview. Both of the group was matched in age, parity, first trimester
body mass index and DMF index. Data were analyzed by descriptive and analytic statistics.
Result
: Demographic characteristics and reproductive histories were similar in two groups. Significantly
different was between two groups in serum level of qualitative CRP (p<0/0005) and serum level of
quantitative CRP (P<0/0005). CRP was strongly associated wish Glucose Challenge Test (GCT) (p<0/0005).
Conclusion
: The results suggest that there is correlation between C-reactive protein and gestational diabetes
mellitus, and inflammation may play an important role in the development of gestational diabetes mellitus and
CRP can act as the risk predictor of GDM. More studies are needed to verify these results.
Key words:
Gestational Diabetes, C - reactive protein, Pregnancy
- Gestational Diabetes
- C - reactive protein
- Pregnancy
ارجاع به مقاله
مراجع
Baraban E, McCoy L, Simon P(2008). "Increasing Prevalence of Gestational Diabetes and Pregnancy-Related
Hypertension in Los Angeles County.California, 1991–2003", Centers for Disease Control, 5(3): A77. [on line] .
[PMCID: 2483543].
- Coustan D, Jovanovic L(2013) "Treatment and course gestational diabetes mellitus", UpToDate Marketing
Professional, 85.133.137.136-7CBA809361-14, 2013 . [on line]. www.uptodate.com>
- Cunningham FG et al (2010) William's Obstetrics.23rd edition. New York, twickler, wendel.
- D’Anna R et al(2006) "C-reactive protein as an early predictor of gestational diabetes mellitus". Journal of
Reproductive Medicine. 51(1) :55-8. [on line]. [PMID: 16482778].
- Dasanayake AP et al(2008) ״Periodontal Pathogens and Gestational Diabetes Mellitus ״. Journal of Dental
Reseach. 87 (4) :328-333. [on line]. [PMCID:PMC2561333].
- Dehghan A et al(2007) "Genetic Variation,C-reactive protein levels,and incidence of Diabetes", Diabetes, 56 (3):
–8, doi: 10.2337/db06-0922. [on line]. [PMID:23049543].
- Di Benedetto A et al(2005) "Inflammatory markers in women with a recent history of gestational diabetes
mellitus", J Endocrinol Invest, 28(1):34-8. [on line]. [PMID:15816369].
- Horvath K et al(2010) "Effects of treatment in women with gestational diabetes mellitus: systematic review and
meta-analysis". British Medical Journal, 340: c1395, doi: 10.1136/bmj.c1395. [on line]
http://www.bmj.com/content/340/bmj.c1395>
- Keshavars M et al (2005). "Gestational diabetes in Iran: incidence, risk factors and pregnancy outcomes",
[abstract]. Diabetes Research and Clinical Practice. 69(3):279-286. [on line]. [PMID:16095925].
www.ncbi.nlm.nih.gov/pubmed/16098925>
- Lau DC et al (2005) "Adipokines: molecular links between obesity and atheroslcerosis". American Journal of
Physioloy , Heart and Circulatory Physiology. 288 (5): 2031–2041. [on line]. [PMID:15653761].
www.ncbi.nlm.nih .gov/pubmed/ 15653761>
- Li X, Lu X (2007) "Study on correlation between C-reactive protein and gestational diabetes mellitus ", Journal of
Nanjing Medical University. 21(6) :382-385. [on line] .<http://www.researchgate.net/publication/22912394>
- Lopez-Garcia E et al (2005) "Consumption of trans fatty acids is related to plasma biomarkers of inflammation and
endothelial dysfunction". The Journal of Nutrition. 135 (3) 562–6. [on line]. [PMID:15735094]. < www.ncbi
.nlm.nih.gov /pubmed/15735094
Pakzad p (2004) [Principles and Interpretation of Clinical Serology Experiments]. 11th edition. Tehran. Noore
danesh press (Persian).
- Pepys MB, Hirschfield GM (2003) . "C-reactive protein: a critical update", The Journal of Clinical Investigation .
(12) 1805–12, 2003 Jun. [on line]. [PMID:12803013]. < www.jci.org /articles/view/ 18921>
- Pradhan AD et al(2001). "C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus",
JAMA, 286 (3) : 327–34, 2001 Jul. [on line]. [PMID:11466099]. < www.ncbi .nlm.nih.gov /pubmed/
>
- Qiu CH et al .( 2004 ) "A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of
gestational diabetes mellitus", Paediatric and Perinatal Epidemiology, 18(5):377-84. [on line].
[PMID:15367325]. < www.ncbi .nlm.nih.gov /pubmed/ 15367325 >
- Retnakaran R et al( 2003) . "C-Reactive Protein and Gestational Diabetes: The Central Role of Maternal Obesity",
The Journal of Clinical Endocrinology & Metabolism. 88(8): 3507-12. [on line]. [PMID:12915627].
www.ncbi .nlm.nih.gov /pubmed/ 12915627>
- Rota S et al (2005) . "C-reactive protein levels in non-obese pregnant women with gestational diabetes". The
Tohoku Journal of Experimental Medicine . 206(4) 341-5. [on line]. [PMID:15997206].
- S. Feig D et al ( 2008). "Risk of development of diabetes mellitus after diagnosis of gestational diabetes .״
Canadian Medical Association. 179(3) 229–234. [on line]. [PMID:18663202].
.gov/pmc/articles/ PMC2474881>
- Sudhindra Mohan B (2006). "C-reactive protein in early months of pregnancy as a screening test for Gestational
diabetes mellitus developing in later mouths of pregnancy", The Journal of Obstetrics and Gynecology of India,
(2):131-133. [on line]. < medind.nic.in/ jaq/t06/i2/jaqt06i2p131.pdf>
- Thompson D, Pepys MB, Wood SP(1999) ״The physiological structure of human C-reactive protein and its
complex with phosphocholine ״ Structure. 7 (2) 169–177. [on line]. [PMID:10368284]. < www.sciencedirect
.com/science/article/pii/ S0969212699800239>
- Wolf M et al (2003). "First-trimester C-Reactive Protein and subsequent gestational diabetes ״. Diabetes Care.
(3):819-24. [on line]. [PMID: 12610043]. < care.diabetesjournals .org/content/26/3/819.full.pdf>
- چکیده مشاهده شده: 719 بار
- PDF (English) دانلود شده: 510 بار