Advances in Nursing & Midwifery

چکیده

Abstract

Background and aim:

Prolonged pregnancy increases the maternal and fetal morbidity and mortality. In order to avoid these complications and to manage prolonged pregnancies, different methods are used. The goal of this study was to evaluate the effect of oral propranolol on labor induction in nulliparous women with prolonged pregnancy.

Material and Methods:

A double blind randomized controlled trial was performed on 146 nulliparas women with a gestational age of 40–42 weeks of pregnancy. Participants were allocated into two groups of propranolol (a combination of oral propranolol and oxytocin) versus placebo (oxytocin and placebo). In propranolol group, 20 mg oral propranolol was placed into the empty capsule and administered immediately before induction. Placebo group received a similar appearance capsules containing starch. Administration was continued every 8 hours until obtained the good contractions. The induction with oxytocin was initiated similar in two groups. The mean duration for obtaining good contractions and Apgar scour was determined. Data were analyzed by SPSS and used descriptive statistics, t test, x2 and exit Fisher test.

Results:

± SD start of good contractions were 190.3 ± 21.4 and 176.2± 11.2 in propranolol group and placebo group consecutively (p<0.05). In the second day of induction, Mean ± SD start of good contractions were 113.5 ± 9.2 and 185 ± 26.8 in propranolol group and placebo group consecutively (p < 0.001).

Conclusion:

Oxytocin combined with oral propranolol can decrease the time needed for start of good contraction in postdate pregnancy.

Kay words:

Induction, oral propranolol, prolonged pregnancy

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