Toxicological and Biosafety Research on Biogenic Zinc Oxide Nanoparticles: A Bibliometric and Science-Mapping Analysis
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 16 (2026),
1 Dey 2026
,
Page 1-7
https://doi.org/10.22037/ijmtfm.v16.53406
Abstract
Background: Biogenic synthesis reduces reliance on hazardous reagents but does not establish the safety of zinc oxide nanoparticles (ZnO NPs). This study mapped research trends and toxicological coverage in this field.
Methods: English-language Scopus research articles published through 2025 were screened using predefined criteria; 272 of 821 records were analyzed using Python-based bibliometric and science-mapping procedures.
Results: The articles appeared in 172 sources between 2014 and 2025, and annual output increased from 1 article in 2014 to 87 in 2025. International co-authorship was 39.71%, with India, Saudi Arabia, and Egypt leading country-associated production. In vitro biocompatibility or cytotoxicity dominated, whereas in vivo systemic toxicity, hemocompatibility, and genotoxicity were less frequent.
Conclusion: The evidence base requires standardized characterization, normal-system comparators, exposure-relevant dosimetry, repeated-dose assessment, and cross-model validation. Green synthesis should be treated as a production route rather than evidence of safety.
- Biogenic nanomaterials, Zinc oxide nanoparticles, Nanosafety, Biocompatibility, Bibliometric analysis
How to Cite
References
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