Bilirubin Induced Encephalopathy, a Review Article
Iranian Journal of Child Neurology,
Vol. 14 No. 1 (2020),
1 Dey 2020
,
Page 7-19
https://doi.org/10.22037/ijcn.v14i1.27890
Abstract
Hyperbilirubinemia is one of the most common neonatal disorders. Delayed diagnosis and treatment of the pathologic and progressive indirect hyperbilirubinemia lead to neurological deficits, defined as bilirubin induced encephalopathy . The incidence of this disorder in underdeveloped countries is much more than developed areas. All neonates with the risk factors for increase the blood level of indirect bilirubin are at risk for bilirubin encephalopathy ,especially preterm neonates which are prone to low bilirubin kernicterus .Bilirubin toxicity can be transient and acute(with early ,intermediate and advanced phases)or be permanent, chronic(kernicterus)and lifelong ( with tetrad of symptoms including visual (upward gaze palsy), auditory (sensory neural hearing loss), dental dysplasia abnormalities, and extrapyramidal disturbances (choreoathetosis cerebral palsy).Beside the abnormal neurologic manifestations of the jaundiced neonates ,brain MRI is the best imaging modality for the confirmation of the diagnosis. Although early treatment of extreme hyperbilirubinemia by phototherapy and exchange transfusion can prevent the BIE, unfortunately the chronic bilirubin encephalopathy does not have definitive treatment
- Bilirubin Induced Encephalopathy
- Kernicterus
- Hyperbilirubinemia
- Neonatal Jaundice
How to Cite
References
-Babaei H, Parham S. Risk Factors of Severe Hyperbilirubinemia in Neonates Undergoing Exchange Transfusion in Imam Reza Hospital Kermanshah-Iran, during 2012 to 2016. International Journal of Pediatrics. 2018 Aug 1;6(8):8061-72.
-Rathore S, Sharashchandra R. A critical review on neonatal hyperbilirubinemia-an ayurvedic perspective. Journal of Ayurveda and Integrative Medicine. 2019 Oct 15.
-Usman F, Diala UM, Shapiro SM, Le Pichon JB, Slusher TM. Acute bilirubin encephalopathy and its progression to kernicterus: current perspectives.2018(8): 33—44
-Wisnowski JL, Panigrahy A, Painter MJ, Watchko JF. Magnetic resonance imaging of bilirubin encephalopathy: current limitations and future promise. InSeminars in perinatology 2014 Nov 1 (Vol. 38, No. 7, pp. 422-428). WB Saunders.
-Helal NF, Ghany EA, Abuelhamd WA, Alradem AY. Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit. World Journal of Pediatrics. 2019 Feb 4; 15(1):42-8.
-Wennberg RP. The blood–brain barrier and bilirubin encephalopathy. Cellular and molecular neurobiology. 2000 Feb 1; 20(1):97-109.
-Liumbruno GM, D’Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, Pupella S, Grazzini G. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh (D) alloimmunisation. Blood transfusion. 2010 Jan; 8(1):8.
-Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF. Hyperbilirubinemia in the newborn infant ≥35 weeks’ gestation: an update with clarifications. Pediatrics. 2009; 124(4):1193–1198.
- Shapiro SM. Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). Journal of perinatology. 2005 Jan; 25(1):54.
-Rose J, Vassar R. Movement disorders due to bilirubin toxicity. InSeminars in Fetal and Neonatal Medicine 2015 Feb 1 (Vol. 20, No. 1, pp. 20-25). WB Saunders.
-:Alkén J, Håkansson S, Ekéus C, Gustafson P, Norman M. Rates of Extreme Neonatal Hyperbilirubinemia and Kernicterus in Children and Adherence to National Guidelines for Screening, Diagnosis, and Treatment in Sweden. JAMA network open. 2019 Mar 1; 2(3):e190858-.
-Morioka I, Nakamura H, Koda T, Yokota T, Okada H, Katayama Y, Kunikata T, Kondo M, Nakamura M, Hosono S, Yasuda S. Current incidence of clinical kernicterus in preterm infants in Japan. Pediatrics International. 2015 Jun; 57(3):494-7.
-Hansen TW. Pathophysiology of kernicterus. InFetal and neonatal physiology 2017 Jan 1 (pp. 1657-1667). Elsevier.
-Ribeiro BN, Lima GD, Ventura N, Gasparetto EL, Marchiori E. Chronic kernicterus: magnetic resonance imaging findings. Radiologiabrasileira. 2016 Dec; 49(6):407-8.
- Parashari UC, Singh R, Yadav R, Aga P. Changes in the globuspallidus in chronic kernicterus. Journal of pediatric neurosciences. 2009 Jul; 4(2):117.
-Usman F, Diala UM, Shapiro SM, Le Pichon JB, Slusher TM. Acute bilirubin encephalopathy and its progression to kernicterus: current perspectives, 2018, Page:
- Kuzniewicz MW, Escobar GJ, Wi S, Liljestrand P, McCulloch C, Newman TB. Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin levels: a nested case-control study. The Journal of pediatrics. 2008 Aug 1; 153(2):234-40.
-Saunders NR, Dreifuss JJ, Dziegielewska KM, Johansson PA, Habgood MD, Møllgård K, Bauer HC. The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history. Frontiers in neuroscience. 2014 Dec 16; 8:404.
- Das S, van Landeghem FK. Clinicopathological Spectrum of Bilirubin Encephalopathy/Kernicterus. Diagnostics. 2019 Mar; 9(1):24.
- Riordan SM, Bittel DC, Le Pichon JB, Gazzin S, Tiribelli C, Watchko JF, Wennberg RP, Shapiro SM. A hypothesis for using pathway genetic load analysis for understanding complex outcomes in bilirubin encephalopathy. Frontiers in neuroscience. 2016 Aug 18; 10:376.
-Hulzebos CV, Dijk PH. Bilirubin–albumin binding, bilirubin/albumin ratios, and free bilirubin levels: Where do we stand?.InSeminars in perinatology 2014 Nov 1 (Vol. 38, No. 7, pp. 412-421). WB Saunders.
-Amin SB. Bilirubin binding capacity in the preterm neonate. Clinics in perinatology. 2016 Jun 1; 43(2):241-57.
-Bhutani VK, Johnson L. Kernicterus in the 21st century: frequently asked questions. Journal of Perinatology. 2009 Jan 28; 29(S1):S20.
- Wusthoff CJ, Loe IM. Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes. InSeminars in Fetal and Neonatal Medicine 2015 Feb 1 (Vol. 20, No. 1, pp. 52-57). WB Saunders.
-Amin SB, Charafeddine L, Guillet R. Transient bilirubin encephalopathy and apnea of prematurity in 28 to 32 weeks gestational age infants. Journal of Perinatology. 2005 Jun; 25(6):386.
-Bhutani VK, Johnson-Hamerman L. The clinical syndrome of bilirubin-induced neurologic dysfunction. InSeminars in Fetal and Neonatal Medicine 2015 Feb 1 (Vol. 20, No. 1, pp. 6-13). WB Saunders.
-Bhutani VK, Wong RJ. Bilirubin neurotoxicity in preterm infants: risk and prevention. Journal of clinical neonatology. 2013 Apr; 2(2):61.
- Peter KB, Tolulope O, Temidayo AA, Kehinde KD. Kernicterus in Two Generations: A Need for More Aggressive Preventive Measures. Iranian Journal of Neonatology IJN. 2014 Jul 1; 5(2):33-6.
-Shapiro SM. Chronic bilirubin encephalopathy: diagnosis and outcome. InSeminars in Fetal and Neonatal Medicine 2010 Jun 1 (Vol. 15, No. 3, pp. 157-163). WB Saunders.
--Olds C, Oghalai JS. Audiologic impairment associated with bilirubin-induced neurologic damage. InSeminars in Fetal and Neonatal Medicine 2015 Feb 1 (Vol. 20, No. 1, pp. 42-46). WB Saunders.
- Slusher TM, Owa JA, Painter MJ, Shapiro SM. The kernicteric faces: facial features of acute bilirubin encephalopathy. Pediatric neurology. 2011 Feb 1; 44(2):153-4.
-Barbério GS, Zingra AC, Santos PS, Machado MA. Green Teeth Related to Bilirubin Levels. ActastomatologicaCroatica. 2018 Mar; 52(1):61.
-Farouk ZL, Muhammed A, Gambo S, Mukhtar-Yola M, Umar Abdullahi S, Slusher TM. Follow-up of children with kernicterus in kano, nigeria. Journal of tropical pediatrics. 2017 Jun 12; 64(3):176-82.
-Cayabyab R, Ramanathan R. High unbound bilirubin for age: a neurotoxin with major effects on the developing brain. Pediatric research. 2019 Jan; 85(2):183-90.
- Radmacher PG, Groves FD, Owa JA, Ofovwe GE, Amuabunos EA, Olusanya BO, Slusher TM. A modified Bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting. BMC pediatrics. 2015 Dec; 15(1):28.
-Nam GS, Kwak SH, Bae SH, Kim SH, Jung J, Choi JY. Hyperbilirubinemia and Follow-up Auditory Brainstem Responses in Preterm Infants. Clinical and experimental otorhinolaryngology. 2019 May;12(2):163.
-Ribeiro BN, Lima GD, Ventura N, Gasparetto EL, Marchiori E. Chronic kernicterus: magnetic resonance imaging findings. Radiologiabrasileira. 2016 Dec; 49(6):407-8.
-Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S, Meloy L, Burgos AE, Hall JY, Stevenson DK. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. The Journal of pediatrics. 2013 Mar 1; 162(3):477-82.
- Shapiro SM, Riordan SM. Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders. Pediatric Research. 2019 Oct 3:1-6.
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