ISSN: 2008-2258
Vol 14, No 4 (2021): Autumn
Non-celiac gluten sensitivity as a rare cause of growth retardation in children: a case series study
Gastroenterology and Hepatology from Bed to Bench,
,
https://doi.org/10.22037/ghfbb.v14i4.2239
Abstract
Background: non-celiac gluten sensitivity (NCGS) is a condition characterized by gastrointestinal and extra-intestinal symptoms which triggered by ingestion of Gluten contained compounds i.e., wheat, rye, and barley, in subjects without celiac disease or wheat allergy.
Case presentation: hereby we present five children and adolescents with final diagnosis of NCGS. All patients had failure to thrive and abdominal pain. Following gluten free diet, clinical symptoms reduced and we detected significant weight and height gain after 1 month of diet.
Conclusion: relationship between failure to thrive and NCGS is still unknown, hence according to mentioned cases, NCGS may be one of the main causes of FTT, which can be prevented by gluten free diets.
Keywords:
- Non-celiac gluten sensitivity, NCGS, Failure to thrive, FTT, Growth retardation
How to Cite
Saneifard, H., Sheikhy, A., Karbasian, F., Eslamian, G., Shakiba, M., & Babaie, D. (2021). Non-celiac gluten sensitivity as a rare cause of growth retardation in children: a case series study . Gastroenterology and Hepatology from Bed to Bench, 14(4). https://doi.org/10.22037/ghfbb.v14i4.2239
References
1. Catassi, C., et al., Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients, 2015. 7(6): p. 4966-4977.
2. Barbaro, M.R., et al., Recent advances in understanding non-celiac gluten sensitivity. F1000Res, 2018. 7.
3. Catassi, C., et al., Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients, 2013. 5(10): p. 3839-53.
4. Volta, U., et al., An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med, 2014. 12: p. 85.
5. Sapone, A., et al., Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med, 2012. 10: p. 13.
6. Volta, U., et al., Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations. Gastroenterol Clin North Am, 2019. 48(1): p. 165-182.
7. van Gils, T., et al., Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands. Nutrients, 2016. 8(11).
8. Cabrera-Chávez, F., et al., Prevalence of Self-Reported Gluten Sensitivity and Adherence to a Gluten-Free Diet in Argentinian Adult Population. Nutrients, 2017. 9(1): p. 81.
9. Carroccio, A., et al., Self-Reported Non-Celiac Wheat Sensitivity in High School Students: Demographic and Clinical Characteristics. Nutrients, 2017. 9(7): p. 771.
10. Molina-Infante, J. and A. Carroccio, Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials. Clin Gastroenterol Hepatol, 2017. 15(3): p. 339-348.
11. Ellis, A. and B.D. Linaker, Non-coeliac gluten sensitivity? Lancet, 1978. 1(8078): p. 1358-9.
12. Cooper, B.T., et al., "Gluten-sensitive diarrhea without evidence of celiac disease". Gastroenterology, 1981. 81(1): p. 192-4.
13. Devulapalli, C.S., Non-coeliac gluten sensitivity in children. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020. 140(2).
14. Volta, U., et al., Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol, 2012. 46(8): p. 680-5.
15. Skovbjerg, H., et al., Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta, 2004. 1690(3): p. 220-30.
16. Sharma, N., et al., Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them. Frontiers in nutrition, 2020. 7: p. 6-6.
17. Fasano, A., et al., Nonceliac gluten sensitivity. Gastroenterology, 2015. 148(6): p. 1195-204.
18. DiGiacomo, D., et al., Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases. World J Gastroenterol, 2013. 19(16): p. 2507-13.
19. Khan, A., M.G. Suarez, and J.A. Murray, Nonceliac Gluten and Wheat Sensitivity. Clin Gastroenterol Hepatol, 2020. 18(9): p. 1913-1922.e1.
20. Lundin, K.E. and A. Alaedini, Non-celiac gluten sensitivity. Gastrointest Endosc Clin N Am, 2012. 22(4): p. 723-34.
21. Sapone, A., et al., Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med, 2011. 9: p. 23.
22. Sapone, A., et al., Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol, 2010. 152(1): p. 75-80.
23. D'Amico, M.A., et al., Presentation of pediatric celiac disease in the United States: prominent effect of breastfeeding. Clin Pediatr (Phila), 2005. 44(3): p. 249-58.
2. Barbaro, M.R., et al., Recent advances in understanding non-celiac gluten sensitivity. F1000Res, 2018. 7.
3. Catassi, C., et al., Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients, 2013. 5(10): p. 3839-53.
4. Volta, U., et al., An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med, 2014. 12: p. 85.
5. Sapone, A., et al., Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med, 2012. 10: p. 13.
6. Volta, U., et al., Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations. Gastroenterol Clin North Am, 2019. 48(1): p. 165-182.
7. van Gils, T., et al., Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands. Nutrients, 2016. 8(11).
8. Cabrera-Chávez, F., et al., Prevalence of Self-Reported Gluten Sensitivity and Adherence to a Gluten-Free Diet in Argentinian Adult Population. Nutrients, 2017. 9(1): p. 81.
9. Carroccio, A., et al., Self-Reported Non-Celiac Wheat Sensitivity in High School Students: Demographic and Clinical Characteristics. Nutrients, 2017. 9(7): p. 771.
10. Molina-Infante, J. and A. Carroccio, Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials. Clin Gastroenterol Hepatol, 2017. 15(3): p. 339-348.
11. Ellis, A. and B.D. Linaker, Non-coeliac gluten sensitivity? Lancet, 1978. 1(8078): p. 1358-9.
12. Cooper, B.T., et al., "Gluten-sensitive diarrhea without evidence of celiac disease". Gastroenterology, 1981. 81(1): p. 192-4.
13. Devulapalli, C.S., Non-coeliac gluten sensitivity in children. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020. 140(2).
14. Volta, U., et al., Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol, 2012. 46(8): p. 680-5.
15. Skovbjerg, H., et al., Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta, 2004. 1690(3): p. 220-30.
16. Sharma, N., et al., Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them. Frontiers in nutrition, 2020. 7: p. 6-6.
17. Fasano, A., et al., Nonceliac gluten sensitivity. Gastroenterology, 2015. 148(6): p. 1195-204.
18. DiGiacomo, D., et al., Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases. World J Gastroenterol, 2013. 19(16): p. 2507-13.
19. Khan, A., M.G. Suarez, and J.A. Murray, Nonceliac Gluten and Wheat Sensitivity. Clin Gastroenterol Hepatol, 2020. 18(9): p. 1913-1922.e1.
20. Lundin, K.E. and A. Alaedini, Non-celiac gluten sensitivity. Gastrointest Endosc Clin N Am, 2012. 22(4): p. 723-34.
21. Sapone, A., et al., Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med, 2011. 9: p. 23.
22. Sapone, A., et al., Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol, 2010. 152(1): p. 75-80.
23. D'Amico, M.A., et al., Presentation of pediatric celiac disease in the United States: prominent effect of breastfeeding. Clin Pediatr (Phila), 2005. 44(3): p. 249-58.
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