Association of heart rate variability, blood pressure variability, and baroreflex sensitivity with gastric motility at rest and during cold pressor test
Gastroenterology and Hepatology from Bed to Bench,
Vol. 14 No. 2 (2021),
8 March 2021
,
Page 132-140
https://doi.org/10.22037/ghfbb.v14i2.1995
Abstract
Aim: To understand the mutual interaction of gastric motility and autonomic functions, the present study evaluated the association of heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS) with gastric motility assessed by electrogastrography (EGG) at rest and during CPT and explored the effect of sympathetic activation by cold pressor test (CPT) on gastric motility.
Background: The autonomic nervous system has a significant influence on gastrointestinal motility. HRV is commonly employed to assess the functions of the autonomic nervous system. BPV and BRS are relatively newer techniques and give a more holistic picture of autonomic functions along with the short-term regulation of blood pressure (BP).
Methods: In fourteen young, healthy subjects, gastric motility was assessed by EGG. Beat-to-beat BP and lead II ECG were recorded to assess HRV, BPV, and BRS. BPV and BRS parameters were calculated for systolic, mean, and diastolic BP. Parameters of HRV and BPV were calculated for time and frequency domains. BRS was calculated by sequence and spectral methods.
Results Significant increases in diastolic BP (p = <0.0001) and EGG frequency (p = 0.0229) were observed during CPT. Significant correlations were observed between EGG frequencies and many of the HRV, BPV, and BRS parameters. The correlation coefficient was found to be highest between total power of HRV and EGG frequencies during baseline (p = 0.0107, r = -0.6571) and during CPT (p = 0.0059, r = -0.6935).
Conclusion: EGG frequency can be decreased by an acute increase in sympathetic activity induced by CPT. The novel findings are the significant correlations between many of the HRV, BPV, and BRS parameters and EGG frequency.
Keywords: Electrogastrography, Heart rate variability, Blood pressure, Baroreflex sensitivity, Autonomic nervous system.
(Please cite as: Prakash K, ThakurA, Malhotra AS. Association of heart rate variability, blood pressure variability, and baroreflex sensitivity with gastric motility at rest and during cold pressor test. Gastroenterol Hepatol Bed Bench 2021;14(2):132-140).
- electrogastrography
- heart rate
- blood pressure
- baroreflex
- autonomic nervous system
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References
Lee OY. Asian motility studies in irritable bowel syndrome. J Neurogastroenterol Motil 2010;16:120-30.
Kedar A, Nikitina Y, Henry OR, Abell KB, Vedanarayanan V, Griswold ME, et al. Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis. Horm Metab Res Horm Stoffwechselforschung Horm Metab 2013;45:47-53.
Sharma P, Makharia G, Yadav R, Dwivedi SN, Deepak KK. Gastric myoelectrical activity in patients with inflammatory bowel disease. J Smooth Muscle Res Nihon Heikatsukin Gakkai Kikanshi 2015;51:50-7.
Usai-Satta P, Oppia F, Lai M, Cabras F. Motility Disorders in Celiac Disease and Non-Celiac Gluten Sensitivity: The Impact of a Gluten-Free Diet. Nutrients 2018;10.
Countee RW. Extrinsic neural influences on gastrointestinal motility. Am Surg 1977;43:621-6.
Altaf MA, Sood MR. The nervous system and gastrointestinal function. Dev Disabil Res Rev 2008;14:87-95.
Miyajima H, Nomura M, Muguruma N, Okahisa T, Shibata H, Okamura S, et al. Relationship among gastric motility, autonomic activity, and portal hemodynamics in patients with liver cirrhosis. J Gastroenterol Hepatol 2001;16:647-59.
Chang J, Rayner CK, Jones KL, Horowitz M. Prognosis of diabetic gastroparesis--a 25-year evaluation. Diabet Med J Br Diabet Assoc 2013;30:e185-188.
Fone DR, Horowitz M, Maddox A, Akkermans LM, Read NW, Dent J. Gastroduodenal motility during the delayed gastric emptying induced by cold stress. Gastroenterology 1990;98:1155-61.
Stern RM, Vasey MW, Hu S, Koch KL. Effects of Cold Stress on Gastric Myoelectric Activity. Neurogastroenterol Motil 1991;3:225-8.
Parkman HP, Hasler WL, Barnett JL, Eaker EY, American Motility Society Clinical GI Motility Testing Task Force. Electrogastrography: a document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc 2003;15:89-102.
Yin J, Chen JDZ. Electrogastrography: methodology, validation and applications. J Neurogastroenterol Motil 2013;19:5-17.
Katoh K, Nomura M, Iga A, Hiasa A, Uehara K, Harada K, et al. Comparison of gastric peristalsis inhibition by scopolamine butylbromide and glucagon: evaluation by electrogastrography and analysis of heart rate variability. J Gastroenterol 2003;38:629-35.
Xu X, Chen DD, Yin J, Chen JDZ. Altered postprandial responses in gastric myoelectrical activity and cardiac autonomic functions in healthy obese subjects. Obes Surg 2014;24:554-60.
Cevette MJ, Pradhan GN, Cocco D, Crowell MD, Galea AM, Bartlett J, et al. Electrogastrographic and autonomic responses during oculovestibular recoupling in flight simulation. Aviat Space Environ Med 2014;85:15-24.
Yin J, Levanon D, Chen JDZ. Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc 2004;16:737-44.
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996;93:1043-65.
Pinna GD, Maestri R, La Rovere MT. Assessment of baroreflex sensitivity from spontaneous oscillations of blood pressure and heart rate: proven clinical value? Physiol Meas 2015;36:741-53.
Kishi T. Baroreflex failure and beat-to-beat blood pressure variation. Hypertens Res Off J Jpn Soc Hypertens 2018;41:547- 52.
Li C, Chang Q, Zhang J, Chai W. Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension. Medicine 2018;97:e0639.
Garg P, Yadav K, Jaryal AK, Kachhawa G, Kriplani A, Deepak KK. Sequential analysis of heart rate variability, blood pressure variability and baroreflex sensitivity in healthy pregnancy. Clin Auton Res Off J Clin Auton Res Soc 2020;30:433-39.
Zhao Q, Gu D, Lu F, Mu J, Wang X, Ji X, et al. Blood Pressure Reactivity to the Cold Pressor Test Predicts Hypertension Among Chinese Adults: The GenSalt Study. Am J Hypertens 2015;28:1347-54.
Jaryal AK, Selvaraj N, Santhosh J, Anand S, Deepak KK. Monitoring of cardiovascular reactivity to cold stress using digital volume pulse characteristics in health and diabetes. J Clin Monit Comput 2009;23:123-30.
Stern RM, Vasey MW, Hu S, Koch KL. Effects of Cold Stress on Gastric Myoelectric Activity. Neurogastroenterol Motil 1991;3:225-8.
Malberg H, Wessel N, Hasart A, Osterziel K-J, Voss A. Advanced analysis of spontaneous baroreflex sensitivity, blood pressure and heart rate variability in patients with dilated cardiomyopathy. Clin Sci Lond Engl 1979 2002;102:465-73.
Parati G, Di Rienzo M, Mancia G. How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J Hypertens 2000;18:7-19.
Di Rienzo M, Castiglioni P, Mancia G, Parati G, Pedotti A. Critical appraisal of indices for the assessment of baroreflex sensitivity. Methods Inf Med 1997;36:246-9.
Pietraszek S, Komorowski D. The simultaneous recording and analysis both EGG and HRV signals. Annu Int Conf IEEE Eng Med Biol Soc 2009;2009:396-9.
Neild PJ, Nijran KS, Yazaki E, Evans DF, Wingate DL, Jewkes R, et al. Delayed gastric emptying in human immunodeficiency virus infection: correlation with symptoms, autonomic function, and intestinal motility. Dig Dis Sci 2000;45:1491-9.
Michel-Chávez A, Estañol B, Gien-López JA, Robles- Cabrera A, Huitrado-Duarte ME, Moreno-Morales R, et al. Heart rate and systolic blood pressure variability on recently diagnosed diabetics. Arq Bras Cardiol 2015;105:276-84.
Voss A, Baier V, Schulz S, Bar KJ. Linear and nonlinear methods for analyses of cardiovascular variability in bipolar disorders. Bipolar Disord 2006;8:441-52.
Rivera AL, Estañol B, Sentíes-Madrid H, Fossion R, Toledo-Roy JC, Mendoza-Temis J, et al. Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. PloS One 2016;11:e0148378.
Casali KR, Schaan BD, Montano N, Massierer D, M F Neto F, Teló GH, et al. Correlation between Very Short and Short-Term Blood Pressure Variability in Diabetic- Hypertensive and Healthy Subjects. Arq Bras Cardiol 2018;110:157-65
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