Gastroenterology and Hepatology from Bed to Bench,
8 March 2021
Background: Memory and learning processes occur in different areas of the brain, especially the hippocampus and amygdala. Considering the expanded use of nanoparticles in recent years, it is important to understand the biological interactions of these materials. Alumina Nanoparticles are used in the provision of some vaccines, drug delivery, water purification and welding industry. Consequently, the potential effects of this substance on the cells and biochemical molecules should be investigated. Materials and Methods: Wistar male rats were divided into three groups; The control group, the sham group (received deionized water) and the test group (received Alumina Nanoparticles in the CA1 region at the dose of 0.37 mg / kg. The shuttle box was used to test the memory. Then the hippocampus of the rats was removed and used for histological examination with the method Haematoxylin & Eosin and tunel tests. Results: The results of the behavioral test showed a significant increase in latency of the experimental group in the dark room compared to the other two groups. Histological examination indicated a reduction in neuronal density, tissue necrosis (hematoxylin-eosin test) and apoptosis (tunel test) in CA1 region in the test group. Conclusion: The results show that Alumina Nanoparticles can be effective in neuronal degeneration and decrease memory and learning ability.