Usefulness of Immature Granulocytes to Predict High Coronary SYNTAX Score in Acute Coronary Syndrome; a Cross-sectional Study Usefulness of immature granulocytes to predict high coronary syntax score
学术急诊医学档案,
卷 8 编号 1 (2020),
1 一月 2020
,
第 e73 页
https://doi.org/10.22037/aaem.v8i1.839
摘要
Introduction: Immature granulocytes (IG) in peripheral blood indicate increased bone marrow activation and inflammation, and SYNTAX score (SS) is an anatomical scoring system based on coronary angiogram. This study, aimed to evaluate the relationship between IG and SS, as a new inflammatory marker in patients with acute coronary syndrome (ACS).
Methods: Patients aged >18 years who were diagnosed with ACS in the emergency department were included in this study, which was planned as a cross-sectional study. Patients were divided into two groups of patients with high and low SSs according to coronary angiography results. Demographic and laboratory parameters were compared between the groups.
Results: Our study consisted of 78 patients diagnosed with ACS, who met the inclusion criteria. The average age of the study group was 59 years, and 67.9% of the patients were male. 21 patients (26.9%) had high SSs and 57 patients (73.1%) had low SSs. Mean IG% was significantly higher in high SS group compared to low SS group (0.71±0.25 vs 0.44±0.21 mg/dl, p<0.001). IG% can present a high SS with 76.2% sensitivity and 75.4% specificity at a cut-off value of 0.7.
Conclusion: IG was significantly higher in ACS patients with high SSs. It seems that IG can be used as a parameter, which is quickly accessible and cheap, in order to predict high SS in ACS patients in daily clinical practice.
- Inflammation; Acute coronary syndrome; Granulocytes; percutaneous coronary intervention; Emergency Medicine; Atherosclerosis
##submission.howToCite##
参考
Sivri, S., et al., Usefulness of white blood cell count to mean platelet volume ratio in the prediction of SYNTAX score in patients with non-ST elevation myocardial infarction. Pakistan journal of medical sciences, 2019. 35(3): p. 824.
Şahin, D.Y., et al., Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction. Angiology, 2013. 64(6): p. 423-429.
Moriya, J., Critical roles of inflammation in atherosclerosis. Journal of cardiology, 2019. 73(1): p. 22-27.
Sari, I., et al., Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography. Kardiologia Polska (Polish Heart Journal), 2015. 73(12): p. 1310-1316.
Silvestre-Roig, C., et al., Neutrophils as regulators of cardiovascular inflammation. Nature Reviews Cardiology, 2020: p. 1-14.
Karon, B.S., et al., Evaluation of lactate, white blood cell count, neutrophil count, procalcitonin and immature granulocyte count as biomarkers for sepsis in emergency department patients. Clinical biochemistry, 2017. 50(16-17): p. 956-958.
Lima, L.R., et al., Automated immature granulocyte count in patients of the intensive care unit with suspected infection. Jornal Brasileiro de Patologia e Medicina Laboratorial, 2019. 55(3): p. 267-280.
Collet, C., et al., Integration of non-invasive functional assessments with anatomical risk stratification in complex coronary artery disease: the non-invasive functional SYNTAX score. Cardiovascular diagnosis and therapy, 2017. 7(2): p. 151.
Sianos, G., et al., The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention, 2005. 1(2): p. 219-27.
Neumann, F.-J., et al., 2018 ESC/EACTS guidelines on myocardial revascularization. European heart journal, 2019. 40(2): p. 87-165.
Schiller, N.B., et al., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. Journal of the American Society of Echocardiography, 1989. 2(5): p. 358-367.
Cerit, L. and Z. Cerit, Vitamin D Deficiency is not Associated with Higher Levels of SYNTAX Score. Brazilian journal of cardiovascular surgery, 2019. 34(1): p. 57-61.
Kundi, H., et al., Association of monocyte/HDL-C ratio with SYNTAX scores in patients with stable coronary artery disease. Herz, 2016. 41(6): p. 523-529.
Kurtul, S., et al., Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction. International Heart Journal, 2014: p. 14-175.
Zuin, M., et al., Correlation and prognostic role of neutrophil to lymphocyte ratio and SYNTAX score in patients with acute myocardial infarction treated with percutaneous coronary intervention: a six-year experience. Cardiovascular Revascularization Medicine, 2017. 18(8): p. 565-571.
Altun, B., et al., The relationship between high-sensitive troponin T, neutrophil lymphocyte ratio and SYNTAX Score. Scandinavian Journal of Clinical and Laboratory Investigation, 2014. 74(2): p. 108-115.
Kurtul, A., et al., Association of platelet-to-lymphocyte ratio with severity and complexity of coronary artery disease in patients with acute coronary syndromes. The American journal of cardiology, 2014. 114(7): p. 972-978.
Sarli, B., et al., Neutrophil-to-lymphocyte ratio is associated with severity of coronary artery ectasia. Angiology, 2014. 65(2): p. 147-151.
Azab, B., et al., Usefulness of neutrophil to lymphocyte ratio in predicting short-and long-term mortality after non–ST-elevation myocardial infarction. The American journal of cardiology, 2010. 106(4): p. 470-476.
Park, J.H., et al., Delta neutrophil index (DNI) as a novel diagnostic and prognostic marker of infection: a systematic review and meta-analysis. Inflammation Research, 2017. 66(10): p. 863-870.
Senthilnayagam, B., et al., Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice. Pathology research international, 2012. 2012.
Seok, Y., et al., Delta neutrophil index: a promising diagnostic and prognostic marker for sepsis. Shock, 2012. 37(3): p. 242-246.
Park, B.H., et al., Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis. BMC infectious diseases, 2011. 11(1): p. 299.
Mathews, E.K., et al., Utility of immature granulocyte percentage in pediatric appendicitis. journal of surgical research, 2014. 190(1): p. 230-234.
- 摘要 ##plugins.themes.ojsPlusA.frontend.article.viewed##: 459 ##plugins.themes.ojsPlusA.frontend.article.times##
- PDF (English) ##plugins.themes.ojsPlusA.frontend.article.downloaded##: 273 ##plugins.themes.ojsPlusA.frontend.article.times##
##plugins.themes.ojsPlusA.frontend.article.downloadstatastics##
##plugins.block.makeSubmission.linkLabel##
SJR
COPE
