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  3. 卷 13 编号 1 (2025): Continuous volume
  4. Case Report

卷 13 编号 1 (2025)

九月 2025

Neurological Crisis Following Intravenous Ozone Therapy; a Case Report

  • Chloe Y Y Wong
  • Komal Saxena
  • John Meneer
  • Koshy George
  • Gerben Keijzers

学术急诊医学档案, 卷 13 编号 1 (2025), 6 九月 2025 , 第 e31 页
https://doi.org/10.22037/aaemj.v13i1.2592 已出版: 2025-01-21

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摘要

Ozone therapy, often marketed as an immune-boosting alternative treatment, lacks robust evidence of efficacy and poses significant safety risks. Despite claims of therapeutic benefits, Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), warn against its use due to its toxic properties and lack of proven benefits at tolerable exposure levels. This case report highlights severe neurological complications, including ischemic infarcts and persistent cognitive deficits, following intravenous ozone (O3) therapy in a previously healthy patient. A 36-year-old woman presented to the emergency department with chest pain, syncope, and generalized seizure shortly after receiving intravenous ozone therapy. Diagnostic imaging revealed multiple ischemic infarcts in the thalamus and cerebellum, consistent with an embolic event. The patient required intensive care unit (ICU) admission, and despite improved neurological function experienced lasting cognitive impairments necessitating long-term rehabilitation.

关键词:
  • Embolism, Air
  • Complementary Therapies
  • Emergency Service
  • Hospital
  • Neurology
  • Ozone
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1.
Wong CYY, Saxena K, Meneer J, George K, Keijzers G. Neurological Crisis Following Intravenous Ozone Therapy; a Case Report. Arch Acad Emerg Med [网际网络]. 2025年1月21日 [见引于 2026年7月7日];13(1):e31. 载于: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2592
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参考

Bocci V, Borrelli E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev. 2009;29(4):646-82.

Code of Federal Regulations NA. Electronic Code of Federal Regulations. CFR - Code of Federal Regulations Title 21. 21CFR801.415. U.S. Food and Drug Administration.: Code of Federal Regulations, National Archives 2024 [updated 27th December 2024 Available from: https://www.ecfr.gov/current/title-21/chapter-I/subchapter-H/part-801/subpart-H/section-801.415.

Haggiag S, Prosperini L, Stasolla A, Gerace C, Tortorella C, Gasperini C. Ozone-induced encephalopathy: A novel iatrogenic entity. Eur J Neurol. 2021;28(8):2471-8.

Sepehr K, Zahra M. Cerebral gas embolism and multifocal ischemic stroke during oxygen-ozone therapy: a case report. BMJ Neurology Open. 2024;6(2):e000885.

Holm SM, Balmes JR. Systematic Review of Ozone Effects on Human Lung Function, 2013 Through 2020. Chest. 2022;161(1):190-201.

Ruidavets JB, Cournot M, Cassadou S, Giroux M, Meybeck M, Ferrières J. Ozone air pollution is associated with acute myocardial infarction. Circulation. 2005;111(5):563-9.

Jiang Y, Huang J, Li G, Wang W, Wang K, Wang J, et al. Ozone pollution and hospital admissions for cardiovascular events. Eur Heart J. 2023;44(18):1622-32.

Serra MEG, Baeza-Noci J, Mendes Abdala CV, Luvisotto MM, Bertol CD, Anzolin AP. The role of ozone treatment as integrative medicine. An evidence and gap map. Front Public Health. 2022;10:1112296.

Murphy RP, Donnellan J. A High-pressure Solution for a High-pressure Situation: Management of Cerebral Air Embolism with Hyperbaric Oxygen Therapy. Cureus. 2019;11(9):e5559.

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