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学术急诊医学档案

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  3. 卷 2 编号 1 (2014): Winter (February)
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卷 2 编号 1 (2014)

二月 2014

The Effect of Intravenous Ketamine in Suicidal Ideation of Emergency Department Patients

  • Parvin Kashani
  • Shiva Yousefian
  • Afshin Amini
  • Kamran Heidari
  • Somaie Younesian
  • Hamid Reza Hatamabadi

学术急诊医学档案, 卷 2 编号 1 (2014), 1 二月 2014 , 第 36-39 页
https://doi.org/10.22037/aaem.v2i1.20 已出版: 2018-11-13

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摘要

Introduction: Suicidal ideation is an emergent problem in the Emergency Department (ED) that often complicates patient disposition and discharge. It has been shown that ketamine possesses fast acting antidepressant and anti-suicidal effects. This study was conducted to examine the effects of a single intravenous bolus of ketamine on patients with suicidal ideations in ED. Methods: Forty-nine subjects with suicidal ideations with or without an unsuccessful suicide attempt, received 0.2 mg/kg of ketamine. Scale for suicidal ideation (SSI) and Montgomery-Abserg depression-rating scale (MADRS) were evaluated before and 40, 80 and 120 minutes after drug intervention. The results were compared using the paired t-test and patients were followed up 10 days after ED admission for remnant suicide ideation. Results: SSI (df: 3, 46; F=80.7; p<0.001) and MADRS (df: 3, 46; F=87.2; p<0.001) scores significantly dropped after ketamine injection; the SSI score before and after 20, 40, and 80 minutes of ketamine injection were 23.0±6.7, 16.2±5.2, 14.3±4.3, and 13.6±4.0 respectively. The MADRS scores were 38.2±9.3, 25.6±7.1, 22.7±6.3, and 22.1±5.95 at the same time intervals. 25.5% of patients were hospitalized, 63.3% received medications and 12.2% discharged. 6.2% of patients had suicidal ideations ten days after ED disposition.  Conclusion: It seems that Ketamine could not be a good choice for fast reduction of suicidal ideations in ED patients. Further studies are needed to determine the optimal dose of ketamine for different patients.
关键词:
  • Ketamine
  • suicide
  • suicidal ideation
  • emergency
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Kashani P, Yousefian S, Amini A, Heidari K, Younesian S, Hatamabadi HR. The Effect of Intravenous Ketamine in Suicidal Ideation of Emergency Department Patients. Arch Acad Emerg Med [网际网络]. 2018年11月13日 [见引于 2026年7月7日];2(1):36-9. 载于: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/20
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参考

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